SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 VAL A 177
SER A 174
ASN A 171
ASP A 225
 VAL  A 177 ( 0.6A)
SER  A 174 ( 0.0A)
ASN  A 171 ( 0.6A)
ASP  A 225 ( 0.6A)
 1.29A 1hwiC-1vhoA:
undetectable		 1hwiC-1vhoA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 VAL A 177
SER A 174
ASN A 171
ASP A 225
 VAL  A 177 ( 0.6A)
SER  A 174 ( 0.0A)
ASN  A 171 ( 0.6A)
ASP  A 225 ( 0.6A)
 1.29A 1hwiD-1vhoA:
undetectable		 1hwiD-1vhoA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 8 ILE A 299
LEU A 324
ILE A 260
GLU A 262
ILE A 246
 ILE  A 299 ( 0.7A)
LEU  A 324 ( 0.6A)
ILE  A 260 ( 0.7A)
GLU  A 262 ( 0.6A)
ILE  A 246 ( 0.7A)
 1.45A 1linA-1vhoA:
undetectable		 1linA-1vhoA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 11 LEU A 185
VAL A 177
GLY A 176
ALA A 322
LEU A 325
 LEU  A 185 ( 0.6A)
VAL  A 177 ( 0.6A)
GLY  A 176 ( 0.0A)
ALA  A 322 ( 0.0A)
LEU  A 325 ( 0.6A)
 1.26A 2bxgA-1vhoA:
undetectable		 2bxgA-1vhoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 ARG A 316
GLY A 243
PRO A 244
 ARG  A 316 ( 0.6A)
GLY  A 243 ( 0.0A)
PRO  A 244 ( 1.1A)
 0.70A 2hreD-1vhoA:
2.4		 2hreD-1vhoA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 LEU A 178
ASP A 317
ILE A 260
VAL A 181
VAL A 177
 LEU  A 178 ( 0.6A)
ASP  A 317 ( 0.6A)
ILE  A 260 ( 0.7A)
VAL  A 181 ( 0.6A)
VAL  A 177 ( 0.6A)
 0.88A 2nnkB-1vhoA:
undetectable		 2nnkB-1vhoA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 5 LEU A 327
VAL A 313
LEU A 240
ARG A 279
 LEU  A 327 ( 0.5A)
VAL  A 313 ( 0.6A)
LEU  A 240 ( 0.6A)
ARG  A 279 ( 0.6A)
 1.10A 2oiqA-1vhoA:
undetectable		 2oiqA-1vhoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 SER A 174
GLU A 274
ASP A 236
 SER  A 174 ( 0.0A)
GLU  A 274 ( 0.6A)
ASP  A 236 ( 0.6A)
 0.80A 2zulA-1vhoA:
undetectable		 2zulA-1vhoA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 SER A 174
GLU A 274
ASP A 236
 SER  A 174 ( 0.0A)
GLU  A 274 ( 0.6A)
ASP  A 236 ( 0.6A)
 0.79A 3dmhA-1vhoA:
undetectable		 3dmhA-1vhoA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 8 ILE A 222
PHE A  62
LEU A 271
VAL A 269
 ILE  A 222 ( 0.7A)
PHE  A  62 ( 1.3A)
LEU  A 271 ( 0.6A)
VAL  A 269 ( 0.6A)
 0.79A 3ua5A-1vhoA:
undetectable		 3ua5A-1vhoA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 8 ILE A 299
ILE A 301
SER A 326
THR A   5
VAL A 181
 ILE  A 299 ( 0.7A)
ILE  A 301 ( 0.7A)
SER  A 326 ( 0.0A)
THR  A   5 ( 0.8A)
VAL  A 181 ( 0.6A)
 1.46A 3ua5A-1vhoA:
undetectable		 3ua5A-1vhoA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 VAL A 252
PHE A 286
GLY A 249
VAL A 276
SER A 300
 VAL  A 252 ( 0.6A)
PHE  A 286 ( 1.3A)
GLY  A 249 ( 0.0A)
VAL  A 276 ( 0.6A)
SER  A 300 ( 0.0A)
 1.49A 4bvaB-1vhoA:
undetectable		 4bvaB-1vhoA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 9 GLY A 148
VAL A  73
GLU A  68
TYR A  21
GLY A  70
 GLY  A 148 ( 0.0A)
VAL  A  73 ( 0.6A)
GLU  A  68 ( 0.6A)
TYR  A  21 ( 1.3A)
GLY  A  70 ( 0.0A)
 1.24A 4fimA-1vhoA:
undetectable		 4fimA-1vhoA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 THR A 160
HIS A 307
LEU A 303
 THR  A 160 ( 0.8A)
HIS  A 307 ( 1.0A)
LEU  A 303 ( 0.6A)
 0.78A 5axdC-1vhoA:
undetectable		 5axdC-1vhoA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 11 LEU A  12
VAL A  32
ILE A  33
ALA A 322
PHE A 198
 LEU  A  12 ( 0.6A)
VAL  A  32 ( 0.5A)
ILE  A  33 ( 0.6A)
ALA  A 322 ( 0.0A)
PHE  A 198 ( 1.3A)
 1.11A 5gpgA-1vhoA:
undetectable		 5gpgA-1vhoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 THR A 227
SER A 300
ASP A 285
 THR  A 227 ( 0.8A)
SER  A 300 ( 0.0A)
ASP  A 285 ( 0.5A)
 0.80A 5kvaA-1vhoA:
undetectable		 5kvaA-1vhoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 GLY A  17
GLU A  68
ALA A 168
ASN A  24
 GLY  A  17 ( 0.0A)
GLU  A  68 ( 0.6A)
ALA  A 168 ( 0.0A)
ASN  A  24 ( 0.6A)
 0.97A 5mvsA-1vhoA:
undetectable		 5mvsA-1vhoA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 8 GLY A  17
GLU A  68
ALA A 168
ASN A  24
 GLY  A  17 ( 0.0A)
GLU  A  68 ( 0.6A)
ALA  A 168 ( 0.0A)
ASN  A  24 ( 0.6A)
 0.96A 5mvsB-1vhoA:
undetectable		 5mvsB-1vhoA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 THR A  42
VAL A 194
SER A 199
VAL A  66
GLU A  22
 THR  A  42 ( 0.8A)
VAL  A 194 ( 0.6A)
SER  A 199 (-0.0A)
VAL  A  66 ( 0.5A)
GLU  A  22 ( 0.6A)
 1.35A 6bzoC-1vhoA:
0.0		 6bzoC-1vhoA:
16.07