SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vhx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1vhx PUTATIVE HOLLIDAY
JUNCTION RESOLVASE
(Bacillus
subtilis) 		5 / 8 ALA A 126
GLY A   9
ALA A 125
THR A  30
THR A  12
 None
 1.27A 1gtnI-1vhxA:
undetectable
1gtnJ-1vhxA:
undetectable		 1gtnI-1vhxA:
20.41
1gtnJ-1vhxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1vhx PUTATIVE HOLLIDAY
JUNCTION RESOLVASE
(Bacillus
subtilis) 		5 / 10 GLY A   9
ALA A 125
THR A  30
THR A  12
ALA A 126
 None
 1.29A 1gtnO-1vhxA:
undetectable
1gtnP-1vhxA:
undetectable		 1gtnO-1vhxA:
20.41
1gtnP-1vhxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1vhx PUTATIVE HOLLIDAY
JUNCTION RESOLVASE
(Bacillus
subtilis) 		5 / 9 GLY A   9
ALA A 125
THR A  30
THR A  12
ALA A 126
 None
 1.27A 1gtnQ-1vhxA:
undetectable
1gtnR-1vhxA:
undetectable		 1gtnQ-1vhxA:
20.41
1gtnR-1vhxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1vhx PUTATIVE HOLLIDAY
JUNCTION RESOLVASE
(Bacillus
subtilis) 		5 / 12 ILE A  54
THR A  86
LEU A  42
VAL A  15
PHE A  79
 None
 1.08A 2qo5A-1vhxA:
undetectable		 2qo5A-1vhxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1vhx PUTATIVE HOLLIDAY
JUNCTION RESOLVASE
(Bacillus
subtilis) 		4 / 7 ILE A  33
GLY A  41
LEU A  93
PHE A  61
 None
 0.77A 5hieB-1vhxA:
undetectable		 5hieB-1vhxA:
19.21