SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vi1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 7 THR A 234
LEU A 232
GLY A 228
LEU A 176
 None
 0.92A 1gtiB-1vi1A:
undetectable		 1gtiB-1vi1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 7 THR A 234
LEU A 232
GLY A 228
LEU A 176
 None
 0.95A 1gtiE-1vi1A:
undetectable		 1gtiE-1vi1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 12 THR A 192
GLY A 174
GLY A 206
VAL A 217
PHE A 135
 None
 1.03A 1nv8A-1vi1A:
2.8		 1nv8A-1vi1A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 12 THR A 192
GLY A 174
GLY A 206
VAL A 217
PHE A 135
 None
 0.97A 1nv8B-1vi1A:
2.4		 1nv8B-1vi1A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 4 SER A 162
VAL A 173
PHE A 285
VAL A 318
 None
 1.48A 1o86A-1vi1A:
undetectable		 1o86A-1vi1A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 6 ILE A 111
VAL A 112
ILE A 307
ASP A  93
 None
 0.73A 1uwhA-1vi1A:
undetectable		 1uwhA-1vi1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 6 ILE A 111
VAL A 112
ILE A 307
ASP A  93
 None
 0.74A 1uwhB-1vi1A:
undetectable		 1uwhB-1vi1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 12 THR A 192
GLY A 174
GLY A 206
VAL A 217
PHE A 135
 None
 1.03A 1vq1B-1vi1A:
2.8		 1vq1B-1vi1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 5 PRO A 125
GLY A 228
ASN A 229
GLY A 141
 None
 0.77A 1zlqA-1vi1A:
undetectable		 1zlqA-1vi1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 12 PHE A 204
LEU A 176
VAL A 221
VAL A 217
GLY A 179
 None
 1.17A 2cbrA-1vi1A:
undetectable		 2cbrA-1vi1A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		3 / 3 HIS A 150
ILE A 118
LEU A 109
 None
 0.66A 2kceA-1vi1A:
undetectable		 2kceA-1vi1A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 12 LEU A  31
ASP A  30
TYR A 279
TYR A 161
ALA A 306
 None
 1.30A 2vdmA-1vi1A:
0.0
2vdmB-1vi1A:
2.3		 2vdmA-1vi1A:
21.17
2vdmB-1vi1A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 7 LEU A 104
ALA A 294
SER A 283
VAL A 303
 None
 0.91A 3d2tA-1vi1A:
undetectable		 3d2tA-1vi1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 8 GLY A 158
ILE A 202
VAL A 173
VAL A 222
 None
 0.70A 3fi0B-1vi1A:
undetectable		 3fi0B-1vi1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 8 GLY A 158
ILE A 202
VAL A 173
VAL A 222
 None
 0.81A 3fi0I-1vi1A:
2.2		 3fi0I-1vi1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		3 / 3 GLY A 141
PRO A 125
LEU A 232
 None
 0.51A 3hcpB-1vi1A:
2.7		 3hcpB-1vi1A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 5 VAL A 165
ILE A 322
MET A 105
ARG A 311
 None
 1.50A 3oezA-1vi1A:
0.0		 3oezA-1vi1A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 12 LEU A 232
LEU A 127
HIS A 295
GLU A 236
ALA A 239
 None
 1.24A 4aqlA-1vi1A:
undetectable		 4aqlA-1vi1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		3 / 3 LEU A 235
GLU A 236
SER A 238
 None
 0.74A 4ccqA-1vi1A:
undetectable		 4ccqA-1vi1A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		3 / 3 ARG A  52
HIS A  32
SER A  50
 None
 0.82A 4mjwA-1vi1A:
3.8
4mjwB-1vi1A:
3.8		 4mjwA-1vi1A:
21.18
4mjwB-1vi1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		3 / 3 SER A  50
ARG A  52
HIS A  32
 None
 0.84A 4mjwA-1vi1A:
3.6
4mjwB-1vi1A:
3.8		 4mjwA-1vi1A:
21.18
4mjwB-1vi1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		3 / 3 ASP A 139
ASN A 229
SER A 283
 None
 0.85A 4obwA-1vi1A:
2.7		 4obwA-1vi1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 9 ALA A  16
SER A  79
GLY A   9
ALA A  98
VAL A   5
 None
 1.26A 4r1zA-1vi1A:
undetectable		 4r1zA-1vi1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 12 ILE A 202
SER A 159
GLY A 158
ALA A 155
THR A 199
 None
 1.30A 4xt8A-1vi1A:
undetectable		 4xt8A-1vi1A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 12 LEU A  35
ILE A  33
LEU A  31
ILE A   3
ILE A  96
 None
 0.92A 4y0rA-1vi1A:
undetectable		 4y0rA-1vi1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 7 SER A 298
GLY A 280
ALA A 302
ILE A  96
 None
 0.73A 4yjiA-1vi1A:
2.2		 4yjiA-1vi1A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 12 VAL A  72
LEU A 284
LEU A 104
ALA A 103
ARG A 114
 None
 1.20A 5nd7B-1vi1A:
2.5		 5nd7B-1vi1A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 10 GLU A 312
PHE A  28
ALA A  27
GLY A  24
ILE A   3
 None
 1.18A 6bniB-1vi1A:
undetectable		 6bniB-1vi1A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		5 / 12 ILE A  25
GLY A  24
ILE A 307
VAL A  55
ILE A  53
 None
 0.98A 6emuA-1vi1A:
4.5		 6emuA-1vi1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Bacillus
subtilis) 		4 / 6 LEU A 136
THR A 126
GLY A 134
ARG A 166
 None
 0.84A 6gtqB-1vi1A:
0.7
6gtqD-1vi1A:
undetectable		 6gtqB-1vi1A:
20.76
6gtqD-1vi1A:
8.88