SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vj0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 8 GLU A 355
ILE A  61
LEU A  11
GLU A  53
VAL A  57
 None
 1.29A 1a29A-1vj0A:
undetectable		 1a29A-1vj0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 ARG A  79
ILE A  33
LEU A  86
ILE A  92
THR A 317
 None
 1.19A 1d1gB-1vj0A:
undetectable		 1d1gB-1vj0A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 11 LEU A 114
HIS A 173
TYR A 113
ALA A 285
GLY A 286
 None
 1.37A 1l5rA-1vj0A:
3.1		 1l5rA-1vj0A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 202
 None
 0.87A 1rl8B-1vj0A:
undetectable		 1rl8B-1vj0A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		4 / 6 ILE A 259
ALA A 256
THR A 251
ALA A 246
 None
 0.74A 1w0gA-1vj0A:
undetectable		 1w0gA-1vj0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 7 ASP A  46
GLY A 135
ILE A  62
PRO A  58
VAL A  57
 None
 1.37A 2aojB-1vj0A:
undetectable		 2aojB-1vj0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 7 GLY A 135
ILE A  62
PRO A  58
VAL A  57
ILE A 123
 None
None
None
None
UNL  A2001 ( 4.8A)
 1.45A 2aojB-1vj0A:
undetectable		 2aojB-1vj0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		4 / 8 SER A 205
PHE A 175
ALA A 174
LEU A 260
 None
 1.10A 2bxkA-1vj0A:
undetectable		 2bxkA-1vj0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 11 GLY A  41
ILE A  62
GLY A 122
VAL A  35
ILE A  37
 None
 0.88A 2fxeB-1vj0A:
undetectable		 2fxeB-1vj0A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		3 / 3 CYH A  43
CYH A 166
HIS A  65
 ZN  A 401 (-2.5A)
ZN  A 401 (-3.0A)
ZN  A 401 (-3.4A)
 0.84A 2iwkA-1vj0A:
undetectable		 2iwkA-1vj0A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		3 / 3 CYH A  43
CYH A 166
HIS A  65
 ZN  A 401 (-2.5A)
ZN  A 401 (-3.0A)
ZN  A 401 (-3.4A)
 0.87A 2iwkB-1vj0A:
0.3		 2iwkB-1vj0A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 202
 None
 0.86A 2q63A-1vj0A:
undetectable		 2q63A-1vj0A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 202
 None
 0.81A 2qakA-1vj0A:
undetectable		 2qakA-1vj0A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		4 / 6 ARG A  96
THR A  99
ARG A 118
PRO A 112
 UNL  A2001 (-3.7A)
None
UNL  A2001 (-2.9A)
None
 1.45A 2ql8A-1vj0A:
undetectable
2ql8B-1vj0A:
undetectable		 2ql8A-1vj0A:
17.69
2ql8B-1vj0A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 GLY A  41
ILE A  62
GLY A 122
VAL A  35
ILE A  37
 None
 0.79A 3d1xA-1vj0A:
undetectable		 3d1xA-1vj0A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 GLY A  41
ILE A  62
GLY A 122
VAL A  35
ILE A  37
 None
 0.88A 3d1yA-1vj0A:
undetectable		 3d1yA-1vj0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 202
 None
 0.83A 3lzuB-1vj0A:
undetectable		 3lzuB-1vj0A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 GLY A  41
ILE A  62
GLY A 122
VAL A  35
ILE A  37
 None
 0.87A 3ndtA-1vj0A:
undetectable		 3ndtA-1vj0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 202
 None
 0.86A 3ndtA-1vj0A:
undetectable		 3ndtA-1vj0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 GLY A  41
ILE A  62
GLY A 122
VAL A  35
ILE A  37
 None
 0.88A 3ndtB-1vj0A:
undetectable		 3ndtB-1vj0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 202
 None
 0.95A 3nduB-1vj0A:
undetectable		 3nduB-1vj0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 202
 None
 0.94A 3nduD-1vj0A:
undetectable		 3nduD-1vj0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		6 / 12 ALA A 203
GLY A 228
ILE A 227
LEU A 221
ARG A 220
VAL A 213
 None
 1.40A 3o7wA-1vj0A:
5.5		 3o7wA-1vj0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 ARG A  56
SER A 167
GLU A  66
ARG A  96
ARG A 118
 UNL  A2001 (-3.3A)
None
ZN  A 401 (-3.2A)
UNL  A2001 (-3.7A)
UNL  A2001 (-2.9A)
 1.40A 4b7qC-1vj0A:
undetectable		 4b7qC-1vj0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		3 / 3 ASP A 148
ARG A 125
THR A 317
 None
 0.85A 4i13A-1vj0A:
2.6		 4i13A-1vj0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		3 / 3 HIS A  65
TRP A  94
SER A  45
 ZN  A 401 (-3.4A)
None
ZN  A 401 ( 4.2A)
 1.20A 4lrhD-1vj0A:
undetectable		 4lrhD-1vj0A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		4 / 6 ASP A 157
SER A  39
ALA A 164
PHE A 198
 None
 1.05A 4nedA-1vj0A:
undetectable		 4nedA-1vj0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		3 / 3 ASP A 148
ARG A 125
THR A 317
 None
 0.85A 4p3rA-1vj0A:
3.0		 4p3rA-1vj0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 PRO A  29
GLY A  76
GLY A  31
ILE A  33
ARG A  30
 None
 1.14A 5fa8A-1vj0A:
8.4		 5fa8A-1vj0A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		3 / 3 ARG A 254
THR A 186
ASP A 257
 None
 0.86A 5g5gA-1vj0A:
undetectable
5g5gB-1vj0A:
undetectable		 5g5gA-1vj0A:
20.63
5g5gB-1vj0A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		3 / 3 MET A  49
HIS A  65
GLY A  44
 None
ZN  A 401 (-3.4A)
None
 0.84A 5gwzB-1vj0A:
undetectable		 5gwzB-1vj0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		3 / 3 GLY A 101
CYH A 106
CYH A 103
 ZN  A 400 ( 4.9A)
ZN  A 400 (-2.3A)
ZN  A 400 (-2.3A)
 0.93A 5inzB-1vj0A:
undetectable		 5inzB-1vj0A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		5 / 12 GLY A  41
ILE A  62
GLY A 122
VAL A  35
ILE A  37
 None
 0.84A 5kqxA-1vj0A:
undetectable		 5kqxA-1vj0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		4 / 7 ARG A  70
ALA A  68
ILE A 141
LEU A 143
 None
 0.82A 5te8C-1vj0A:
undetectable		 5te8C-1vj0A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING
(Thermotoga
maritima) 		4 / 6 ALA A 262
SER A 167
GLY A 168
PHE A 182
 None
 0.80A 6f8cA-1vj0A:
undetectable		 6f8cA-1vj0A:
11.29