SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vj7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		3 / 3 ASP A  67
PHE A  27
VAL A  98
 None
 0.69A 1kijB-1vj7A:
undetectable		 1kijB-1vj7A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		5 / 12 LEU A  64
ALA A  62
LEU A  66
VAL A  12
ALA A 143
 None
 1.02A 1sn5B-1vj7A:
0.0
1sn5D-1vj7A:
0.0		 1sn5B-1vj7A:
14.69
1sn5D-1vj7A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		4 / 7 ILE A 101
LEU A  61
ILE A 135
ASP A 134
 None
 0.83A 1yc2E-1vj7A:
undetectable		 1yc2E-1vj7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		4 / 7 LEU A 234
PHE A 235
GLY A 236
ILE A 268
 None
 0.91A 2bdmA-1vj7A:
undetectable		 2bdmA-1vj7A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		3 / 3 ARG A 290
VAL A 282
THR A 313
 None
 0.62A 2nmzA-1vj7A:
undetectable		 2nmzA-1vj7A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		3 / 3 ARG A 290
VAL A 282
THR A 313
 None
 0.65A 2nnkA-1vj7A:
undetectable		 2nnkA-1vj7A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		5 / 12 HIS A  53
ASP A  78
ASP A 144
GLU A 166
ILE A 163
 MN  A 997 (-3.3A)
MN  A 997 ( 3.9A)
MN  A 997 (-2.5A)
None
None
 1.07A 3b7pC-1vj7A:
undetectable		 3b7pC-1vj7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		4 / 5 ILE A 225
TYR A 239
MET A 272
ILE A 326
 None
 1.16A 3eteB-1vj7A:
undetectable
3eteC-1vj7A:
undetectable		 3eteB-1vj7A:
21.93
3eteC-1vj7A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		3 / 3 ARG A 290
VAL A 282
THR A 313
 None
 0.72A 3k4vA-1vj7A:
undetectable		 3k4vA-1vj7A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		3 / 3 ARG A 290
VAL A 282
THR A 313
 None
 0.75A 3k4vD-1vj7A:
undetectable		 3k4vD-1vj7A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		3 / 3 ARG A 290
VAL A 282
THR A 313
 None
 0.73A 3nduD-1vj7A:
undetectable		 3nduD-1vj7A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		3 / 3 ARG A 290
VAL A 282
THR A 313
 None
 0.61A 3pwrA-1vj7A:
undetectable		 3pwrA-1vj7A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		3 / 3 ARG A 290
VAL A 282
THR A 313
 None
 0.71A 3tl9A-1vj7A:
undetectable		 3tl9A-1vj7A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		5 / 11 ILE A 322
ILE A 268
VAL A 315
THR A 313
ILE A 285
 None
 1.09A 5lg3A-1vj7A:
undetectable		 5lg3A-1vj7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		5 / 12 ILE A 322
ILE A 268
VAL A 315
THR A 313
ILE A 285
 None
 1.04A 5lg3E-1vj7A:
undetectable		 5lg3E-1vj7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		5 / 10 ILE A 322
ILE A 268
VAL A 315
THR A 313
ILE A 285
 None
 1.05A 5lg3F-1vj7A:
undetectable		 5lg3F-1vj7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		5 / 10 ILE A 322
ILE A 268
VAL A 315
THR A 313
ILE A 285
 None
 1.04A 5lg3G-1vj7A:
undetectable		 5lg3G-1vj7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		5 / 10 ILE A 322
ILE A 268
VAL A 315
THR A 313
ILE A 285
 None
 1.04A 5lg3H-1vj7A:
undetectable		 5lg3H-1vj7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		5 / 12 ILE A 322
ILE A 268
VAL A 315
THR A 313
ILE A 285
 None
 1.08A 5lg3J-1vj7A:
0.4		 5lg3J-1vj7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		4 / 7 TYR A  19
LEU A  64
THR A  70
VAL A  57
 None
 1.08A 5ov9A-1vj7A:
undetectable		 5ov9A-1vj7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1vj7 BIFUNCTIONAL
RELA/SPOT
(Streptococcus
dysgalactiae) 		4 / 7 ILE A 324
GLU A 287
HIS A 286
VAL A 315
 None
 0.98A 6j20A-1vj7A:
undetectable		 6j20A-1vj7A:
19.18