SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 6 PHE A  20
LEU A  77
VAL A  44
VAL A 236
 None
 1.04A 1e7aB-1vk1A:
0.0		 1e7aB-1vk1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 7 GLU A 131
PHE A 106
MET A 189
ALA A 187
 None
MLY  A 107 ( 4.8A)
None
None
 1.25A 1linA-1vk1A:
undetectable		 1linA-1vk1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		3 / 3 ASP A 109
ASP A 195
LYS A 113
 MLY  A 112 ( 3.8A)
MLY  A 107 ( 4.2A)
MLY  A 112 ( 2.9A)
 1.04A 1lqtB-1vk1A:
undetectable		 1lqtB-1vk1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		3 / 3 ASP A 109
ASP A 195
LYS A 113
 MLY  A 112 ( 3.8A)
MLY  A 107 ( 4.2A)
MLY  A 112 ( 2.9A)
 1.07A 1lquB-1vk1A:
undetectable		 1lquB-1vk1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A 101
THR A 222
SER A 219
VAL A 161
 MLY  A 221 ( 4.7A)
MLY  A 221 ( 4.3A)
MLY  A 159 ( 4.5A)
None
 1.16A 1tv8B-1vk1A:
undetectable		 1tv8B-1vk1A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 5 ILE A  89
SER A  87
PHE A  20
PRO A  86
 None
 1.25A 3bjwC-1vk1A:
undetectable		 3bjwC-1vk1A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 11 ALA A  85
ILE A  21
MET A  26
LEU A  56
VAL A  88
 None
 1.20A 3gyqB-1vk1A:
undetectable		 3gyqB-1vk1A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 8 PHE A  40
LEU A  80
PHE A  50
LEU A 238
 None
 0.94A 3i45A-1vk1A:
undetectable		 3i45A-1vk1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ASP A 169
ARG A  35
PRO A 104
TRP A 102
 None
MLY  A 172 ( 3.6A)
None
MLY  A 221 ( 3.8A)
 0.95A 4uhxA-1vk1A:
undetectable		 4uhxA-1vk1A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ASP A 169
ARG A  35
PRO A 104
TRP A 102
 None
MLY  A 172 ( 3.6A)
None
MLY  A 221 ( 3.8A)
 0.95A 4uhxA-1vk1A:
undetectable		 4uhxA-1vk1A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		3 / 3 VAL A 113
LEU A 117
VAL A 164
 MLY  A 112 ( 3.4A)
None
None
 0.54A 4wq4A-1vk1A:
undetectable		 4wq4A-1vk1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 12 VAL A 110
ASN A 111
ILE A 114
LYS A 118
GLY A 145
 None
 0.82A 5j2tC-1vk1A:
undetectable		 5j2tC-1vk1A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 8 HIS A  72
PHE A  50
HIS A  29
THR A 223
 PO4  A 301 (-3.7A)
None
None
NA  A 302 (-3.5A)
 1.44A 5yj1G-1vk1A:
0.0
5yj1Y-1vk1A:
0.0		 5yj1G-1vk1A:
19.23
5yj1Y-1vk1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		4 / 8 HIS A  29
THR A 223
HIS A  72
PHE A  50
 None
NA  A 302 (-3.5A)
PO4  A 301 (-3.7A)
None
 1.40A 5yj1k-1vk1A:
0.0
5yj1t-1vk1A:
0.0		 5yj1k-1vk1A:
19.23
5yj1t-1vk1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 11 HIS A  29
ILE A  67
HIS A  71
HIS A 225
PRO A  53
 None
MLY  A  27 ( 3.8A)
PO4  A 301 (-3.9A)
None
None
 1.48A 5z0fA-1vk1A:
undetectable
5z0fB-1vk1A:
undetectable		 5z0fA-1vk1A:
14.46
5z0fB-1vk1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 11 HIS A  29
ILE A  67
HIS A  71
HIS A 225
PRO A  53
 None
MLY  A  27 ( 3.8A)
PO4  A 301 (-3.9A)
None
None
 1.48A 5z0gA-1vk1A:
undetectable
5z0gB-1vk1A:
undetectable		 5z0gA-1vk1A:
14.46
5z0gB-1vk1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1vk1 CONSERVED
HYPOTHETICAL PROTEIN
(Pyrococcus
furiosus) 		5 / 11 HIS A  29
ILE A  67
HIS A  71
HIS A 225
PRO A  53
 None
MLY  A  27 ( 3.8A)
PO4  A 301 (-3.9A)
None
None
 1.49A 5z0iA-1vk1A:
undetectable
5z0iB-1vk1A:
undetectable		 5z0iA-1vk1A:
14.46
5z0iB-1vk1A:
16.39