SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		4 / 7 ARG A 108
HIS A 231
PHE A 283
ILE A 182
 None
 1.45A 1tdnA-1vkdA:
undetectable		 1tdnA-1vkdA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		5 / 12 GLY A 301
TYR A 105
ALA A 308
ALA A 302
TYR A 272
 None
 1.36A 2avdA-1vkdA:
undetectable		 2avdA-1vkdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		5 / 12 GLY A 301
TYR A 105
ALA A 308
ALA A 302
TYR A 272
 None
 1.32A 2avdB-1vkdA:
undetectable		 2avdB-1vkdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		4 / 6 SER A  76
ASP A  78
PRO A  12
VAL A  49
 None
 1.18A 2hdnI-1vkdA:
undetectable
2hdnJ-1vkdA:
undetectable
2hdnL-1vkdA:
undetectable		 2hdnI-1vkdA:
8.36
2hdnJ-1vkdA:
21.56
2hdnL-1vkdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		5 / 11 ALA A 287
ILE A 314
GLY A 312
ALA A 246
ILE A 229
 None
 1.14A 2idwA-1vkdA:
undetectable		 2idwA-1vkdA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		4 / 7 ILE A  84
GLY A  34
TYR A 299
VAL A  49
 None
 0.93A 3elzA-1vkdA:
undetectable		 3elzA-1vkdA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		4 / 8 ILE A 213
SER A 243
GLY A 232
ASN A 210
 None
 0.84A 3lslA-1vkdA:
undetectable
3lslD-1vkdA:
undetectable		 3lslA-1vkdA:
21.94
3lslD-1vkdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		4 / 8 ASN A 210
ILE A 213
SER A 243
GLY A 232
 None
 0.86A 3lslA-1vkdA:
undetectable
3lslD-1vkdA:
undetectable		 3lslA-1vkdA:
21.94
3lslD-1vkdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		5 / 12 PHE A 277
HIS A 306
GLY A 276
GLY A  41
ASN A  66
 None
 1.28A 3v3oB-1vkdA:
undetectable		 3v3oB-1vkdA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		3 / 3 TYR A 117
ASP A 114
ASP A 136
 None
 0.74A 4a6eA-1vkdA:
undetectable		 4a6eA-1vkdA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		5 / 12 ILE A 229
GLY A 225
VAL A 321
ILE A 317
VAL A 318
 None
 1.04A 4c9lA-1vkdA:
undetectable		 4c9lA-1vkdA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		5 / 12 ILE A 229
GLY A 225
VAL A 321
ILE A 317
VAL A 318
 None
 1.01A 4c9oA-1vkdA:
undetectable		 4c9oA-1vkdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		5 / 12 ILE A 229
GLY A 225
VAL A 321
ILE A 317
VAL A 318
 None
 1.02A 4c9oB-1vkdA:
undetectable		 4c9oB-1vkdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		4 / 6 TYR A  20
THR A  21
PRO A  23
PHE A 320
 None
 0.92A 4kf9A-1vkdA:
undetectable		 4kf9A-1vkdA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1vkd CONSERVED
HYPOTHETICAL PROTEIN
TM1225
(Thermotoga
maritima) 		4 / 9 HIS A  64
ILE A  62
ILE A  33
ILE A  32
 None
 0.84A 5vkqB-1vkdA:
undetectable
5vkqC-1vkdA:
undetectable		 5vkqB-1vkdA:
10.97
5vkqC-1vkdA:
10.97