SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vkf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN
(Thermotoga
maritima) 		6 / 12 ARG A 153
ILE A   5
ALA A 142
GLY A 125
HIS A 158
ILE A 162
 None
 1.39A 1bx4A-1vkfA:
undetectable		 1bx4A-1vkfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN
(Thermotoga
maritima) 		5 / 11 GLY A  71
ALA A  72
ASP A  73
ILE A  39
VAL A  54
 None
 0.81A 1ohrA-1vkfA:
undetectable		 1ohrA-1vkfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN
(Thermotoga
maritima) 		4 / 8 VAL A 146
GLU A 147
SER A 166
ILE A 162
 None
 0.86A 1pk7B-1vkfA:
undetectable		 1pk7B-1vkfA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN
(Thermotoga
maritima) 		5 / 11 GLY A  71
ALA A  72
ASP A  73
ILE A  39
VAL A  54
 None
 0.72A 2nnpA-1vkfA:
undetectable		 2nnpA-1vkfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A  71
ALA A  72
ASP A  73
ILE A  39
VAL A  54
 None
 0.83A 3el1B-1vkfA:
undetectable		 3el1B-1vkfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN
(Thermotoga
maritima) 		4 / 8 GLY A  71
ALA A  72
ASP A  73
VAL A  54
 None
 0.56A 3em6A-1vkfA:
undetectable		 3em6A-1vkfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN
(Thermotoga
maritima) 		5 / 12 GLU A 150
GLU A 151
ARG A 153
VAL A 159
ILE A 162
 None
 1.20A 3jayA-1vkfA:
0.0		 3jayA-1vkfA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A   6
ALA A 143
ILE A  76
PHE A  24
THR A 139
 None
CIT  A 501 (-3.4A)
None
None
None
 1.29A 4cd2A-1vkfA:
undetectable		 4cd2A-1vkfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN
(Thermotoga
maritima) 		4 / 5 HIS A  36
VAL A  47
GLY A  71
ALA A  72
 None
 0.87A 5hwaA-1vkfA:
0.0		 5hwaA-1vkfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A  40
LEU A  26
ILE A  18
PRO A  20
SER A 165
 None
CIT  A 501 (-4.9A)
None
None
CIT  A 501 (-2.6A)
 1.49A 6dm2B-1vkfA:
2.7
6dm2C-1vkfA:
2.3		 6dm2B-1vkfA:
17.11
6dm2C-1vkfA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN
(Thermotoga
maritima) 		5 / 10 ILE A  18
PRO A  20
SER A 165
LEU A  40
LEU A  26
 None
None
CIT  A 501 (-2.6A)
None
CIT  A 501 (-4.9A)
 1.49A 6dm2A-1vkfA:
2.3
6dm2D-1vkfA:
undetectable		 6dm2A-1vkfA:
17.11
6dm2D-1vkfA:
17.11