SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vkh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  37
GLY A  38
SER A 110
PHE A 169
HIS A 243
 None
 0.80A 1dx6A-1vkhA:
16.0		 1dx6A-1vkhA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 211
HIS A 243
HIS A 207
ILE A 153
 None
 0.94A 1ei6C-1vkhA:
undetectable		 1ei6C-1vkhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 111
GLY A 112
GLY A  38
PHE A  50
LEU A  14
 None
 1.07A 1fduA-1vkhA:
4.7		 1fduA-1vkhA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  37
GLY A  38
SER A 110
PHE A 169
HIS A 243
 None
 0.81A 1qtiA-1vkhA:
15.0		 1qtiA-1vkhA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  37
GLY A  38
SER A 110
PHE A 169
HIS A 243
 None
 0.82A 1w6rA-1vkhA:
15.9		 1w6rA-1vkhA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  37
GLY A  38
SER A 110
PHE A 169
HIS A 243
 None
 0.84A 1w76B-1vkhA:
15.1		 1w76B-1vkhA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_2
(RENIN)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 111
TYR A 181
PRO A  82
PHE A 115
 None
 1.33A 3d91B-1vkhA:
0.0		 3d91B-1vkhA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 192
ALA A 195
GLU A 183
VAL A 147
ILE A 119
 None
 1.24A 3dl9A-1vkhA:
undetectable		 3dl9A-1vkhA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 10 THR A  93
GLY A 139
LEU A 140
LEU A 141
ILE A 119
 None
 1.33A 3kvrA-1vkhA:
4.5		 3kvrA-1vkhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 124
SER A 131
GLN A 134
 None
 1.02A 3si7A-1vkhA:
undetectable		 3si7A-1vkhA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 159
TYR A 154
LEU A 214
TYR A 163
 None
 1.08A 3v81A-1vkhA:
2.4		 3v81A-1vkhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 8 GLN A  68
ASN A  55
GLN A  22
THR A  62
 None
 1.00A 4d1yA-1vkhA:
undetectable
4d1yB-1vkhA:
3.2		 4d1yA-1vkhA:
23.84
4d1yB-1vkhA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  37
GLY A  38
SER A 110
PHE A 169
HIS A 243
 None
 0.80A 4ey6A-1vkhA:
16.2		 4ey6A-1vkhA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  37
GLY A  38
SER A 110
PHE A 169
HIS A 243
 None
 0.86A 4ey6B-1vkhA:
15.5		 4ey6B-1vkhA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A  73
HIS A  36
ILE A  35
HIS A 109
 None
 1.12A 4g5jA-1vkhA:
undetectable		 4g5jA-1vkhA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 170
ILE A 153
SER A 110
PHE A 174
LEU A 159
 None
 1.46A 4lhmA-1vkhA:
undetectable		 4lhmA-1vkhA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 122
MET A 137
PHE A 115
PHE A 174
 None
 1.03A 4ltwA-1vkhA:
undetectable		 4ltwA-1vkhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  94
THR A  13
ASP A  11
 None
 0.89A 5g5gA-1vkhA:
undetectable
5g5gB-1vkhA:
undetectable		 5g5gA-1vkhA:
21.63
5g5gB-1vkhA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		6 / 12 PHE A 174
TYR A 181
LEU A 156
ILE A  35
ILE A 153
LEU A  85
 None
 1.22A 5h8tA-1vkhA:
undetectable		 5h8tA-1vkhA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 148
VAL A 107
TYR A  34
ILE A  57
 None
 0.97A 5iwuA-1vkhA:
undetectable		 5iwuA-1vkhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 4 TYR A 209
SER A 208
GLU A 212
ASP A 151
 None
 1.49A 5lsaA-1vkhA:
3.2		 5lsaA-1vkhA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 138
LEU A 141
SER A 200
SER A 197
LEU A 196
 None
 1.21A 5mwyA-1vkhA:
undetectable		 5mwyA-1vkhA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 1vkh PUTATIVE SERINE
HYDROLASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  50
ASP A  49
GLY A 112
GLY A  38
 None
 1.02A 5n9xA-1vkhA:
3.5		 5n9xA-1vkhA:
19.74