SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		4 / 8 ASP A 126
SER A 128
GLY A  79
THR A  96
 MN  A 400 (-2.6A)
UNL  A 600 (-2.6A)
None
UNL  A 600 (-4.0A)
 0.78A 1jr1B-1vkmA:
undetectable		 1jr1B-1vkmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		4 / 6 ILE A 164
VAL A  13
ILE A  51
ILE A   7
 None
 0.87A 1uwhB-1vkmA:
undetectable		 1uwhB-1vkmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		4 / 6 SER A 104
ILE A  51
ALA A  49
ALA A 279
 None
 0.80A 1w0gA-1vkmA:
undetectable		 1w0gA-1vkmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		3 / 3 ARG A 170
SER A 201
TYR A 199
 None
 0.78A 1x70A-1vkmA:
3.1		 1x70A-1vkmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		5 / 8 GLY A  61
ALA A  49
VAL A 112
ILE A  58
ILE A 109
 None
 1.23A 3ekpA-1vkmA:
undetectable		 3ekpA-1vkmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		5 / 12 GLU A  66
ILE A   3
LEU A 103
GLY A  61
SER A  63
 None
 1.49A 4djfB-1vkmA:
undetectable		 4djfB-1vkmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		5 / 12 HIS A  23
ALA A  99
GLU A  17
ALA A  94
VAL A  78
 None
None
UNL  A 600 (-2.9A)
None
None
 1.12A 4hfpD-1vkmA:
undetectable		 4hfpD-1vkmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		4 / 5 VAL A 113
MET A  16
GLU A  17
LEU A 268
 None
None
UNL  A 600 (-2.9A)
None
 1.28A 4hojA-1vkmA:
undetectable		 4hojA-1vkmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		5 / 12 LEU A 141
PHE A 174
PHE A 156
LEU A 150
VAL A 120
 None
 1.21A 4ib4A-1vkmA:
undetectable		 4ib4A-1vkmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		3 / 3 ARG A 138
GLU A 206
ARG A 105
 None
 0.98A 4mwvA-1vkmA:
undetectable		 4mwvA-1vkmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		5 / 12 VAL A 217
ASN A 271
LEU A 249
PHE A 177
GLY A 116
 None
None
None
None
UNL  A 600 (-4.9A)
 1.10A 4pevC-1vkmA:
undetectable		 4pevC-1vkmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		5 / 9 VAL A   1
LEU A  54
LEU A 103
THR A  95
ILE A  51
 None
 1.27A 4ubsA-1vkmA:
undetectable		 4ubsA-1vkmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		5 / 12 LEU A 103
GLU A  82
GLY A  79
VAL A  78
THR A  95
 None
 1.29A 5o4yD-1vkmA:
undetectable
5o4yE-1vkmA:
undetectable		 5o4yD-1vkmA:
1.95
5o4yE-1vkmA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		3 / 3 ARG A 184
PHE A 177
LEU A 214
 None
 0.65A 5veuA-1vkmA:
undetectable		 5veuA-1vkmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464
(Thermotoga
maritima) 		5 / 9 LEU A 237
PRO A 122
VAL A 244
SER A 148
LEU A 150
 None
 1.36A 6fdyU-1vkmA:
0.0		 6fdyU-1vkmA:
22.74