SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 10 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.85A 1hsgA-1vknA:
undetectable		 1hsgA-1vknA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.89A 1hxbB-1vknA:
undetectable		 1hxbB-1vknA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 GLY A 144
LEU A 126
ASP A  93
GLY A  95
ALA A 312
 None
 1.14A 1jg2A-1vknA:
2.7		 1jg2A-1vknA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 9 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.86A 1ohrB-1vknA:
undetectable		 1ohrB-1vknA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 10 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 0.92A 1pxxA-1vknA:
undetectable		 1pxxA-1vknA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 0.91A 1pxxC-1vknA:
undetectable		 1pxxC-1vknA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.09A 1v54A-1vknA:
undetectable
1v54C-1vknA:
undetectable		 1v54A-1vknA:
21.35
1v54C-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.12A 1v55A-1vknA:
undetectable
1v55C-1vknA:
undetectable		 1v55A-1vknA:
21.35
1v55C-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.10A 1v55C-1vknA:
0.0
1v55N-1vknA:
undetectable
1v55P-1vknA:
0.0		 1v55C-1vknA:
22.71
1v55N-1vknA:
21.35
1v55P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 SER A 239
VAL A 170
VAL A 150
HIS A 206
 None
 0.77A 2ddwA-1vknA:
3.7		 2ddwA-1vknA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.08A 2dyrA-1vknA:
undetectable
2dyrC-1vknA:
undetectable		 2dyrA-1vknA:
21.35
2dyrC-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.13A 2dysA-1vknA:
undetectable
2dysC-1vknA:
undetectable		 2dysA-1vknA:
21.35
2dysC-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.07A 2dysN-1vknA:
undetectable
2dysP-1vknA:
undetectable		 2dysN-1vknA:
21.35
2dysP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.12A 2eijA-1vknA:
undetectable
2eijC-1vknA:
undetectable		 2eijA-1vknA:
21.35
2eijC-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.10A 2eijN-1vknA:
undetectable
2eijP-1vknA:
undetectable		 2eijN-1vknA:
21.35
2eijP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.11A 2eilA-1vknA:
undetectable
2eilC-1vknA:
undetectable		 2eilA-1vknA:
21.35
2eilC-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.08A 2eilN-1vknA:
undetectable
2eilP-1vknA:
undetectable		 2eilN-1vknA:
21.35
2eilP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.10A 2einA-1vknA:
undetectable
2einC-1vknA:
undetectable		 2einA-1vknA:
21.35
2einC-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.89A 2f8gB-1vknA:
undetectable		 2f8gB-1vknA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.85A 2o4lB-1vknA:
undetectable		 2o4lB-1vknA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.79A 2pymB-1vknA:
undetectable		 2pymB-1vknA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.78A 2pynB-1vknA:
undetectable		 2pynB-1vknA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.81A 2q63A-1vknA:
undetectable		 2q63A-1vknA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.82A 2q63B-1vknA:
undetectable		 2q63B-1vknA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.82A 2qakB-1vknA:
undetectable		 2qakB-1vknA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.90A 2r5pA-1vknA:
undetectable		 2r5pA-1vknA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.90A 2r5pC-1vknA:
undetectable		 2r5pC-1vknA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 8 ALA A 157
LEU A 158
LEU A 214
ILE A 241
VAL A 224
 None
 1.00A 2uxpA-1vknA:
undetectable		 2uxpA-1vknA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 9 TYR A 260
LEU A 129
LEU A 214
LEU A 158
ALA A 157
 None
 1.26A 2vcvE-1vknA:
undetectable		 2vcvE-1vknA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 9 TYR A 260
LEU A 129
LEU A 214
LEU A 158
ALA A 157
 None
 1.24A 2vcvH-1vknA:
undetectable		 2vcvH-1vknA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.07A 2y69A-1vknA:
undetectable
2y69C-1vknA:
undetectable		 2y69A-1vknA:
21.35
2y69C-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 GLY A 289
ALA A 153
ALA A 157
LEU A 299
VAL A 243
 None
 0.95A 2yqzB-1vknA:
2.9		 2yqzB-1vknA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.10A 2zxwA-1vknA:
undetectable
2zxwC-1vknA:
undetectable		 2zxwA-1vknA:
21.35
2zxwC-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.07A 2zxwN-1vknA:
undetectable
2zxwP-1vknA:
undetectable		 2zxwN-1vknA:
21.35
2zxwP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A  73
VAL A 317
SER A 313
GLY A   8
ILE A   6
 None
 1.35A 3a65A-1vknA:
0.0		 3a65A-1vknA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.11A 3abkA-1vknA:
undetectable
3abkC-1vknA:
undetectable		 3abkA-1vknA:
21.35
3abkC-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.02A 3ablA-1vknA:
undetectable
3ablC-1vknA:
0.0
3ablP-1vknA:
0.0		 3ablA-1vknA:
21.35
3ablC-1vknA:
22.71
3ablP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.02A 3ablC-1vknA:
undetectable
3ablN-1vknA:
undetectable
3ablP-1vknA:
undetectable		 3ablC-1vknA:
22.71
3ablN-1vknA:
21.35
3ablP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.08A 3abmA-1vknA:
undetectable
3abmC-1vknA:
undetectable
3abmP-1vknA:
undetectable		 3abmA-1vknA:
21.35
3abmC-1vknA:
22.71
3abmP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.06A 3abmN-1vknA:
undetectable
3abmP-1vknA:
undetectable		 3abmN-1vknA:
21.35
3abmP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.09A 3ag1N-1vknA:
undetectable
3ag1P-1vknA:
0.0		 3ag1N-1vknA:
21.35
3ag1P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.08A 3ag2N-1vknA:
undetectable
3ag2P-1vknA:
undetectable		 3ag2N-1vknA:
21.35
3ag2P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.16A 3ag3A-1vknA:
undetectable
3ag3C-1vknA:
undetectable		 3ag3A-1vknA:
21.35
3ag3C-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.11A 3ag3N-1vknA:
undetectable
3ag3P-1vknA:
undetectable		 3ag3N-1vknA:
21.35
3ag3P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.78A 3bvbA-1vknA:
undetectable		 3bvbA-1vknA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 152
GLY A 311
ILE A 237
VAL A 286
GLY A 178
 None
 1.02A 3bwcB-1vknA:
3.2		 3bwcB-1vknA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 LEU A 308
GLU A  16
SER A 177
THR A 234
 None
 1.21A 3dzgB-1vknA:
undetectable		 3dzgB-1vknA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 10 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.82A 3em3B-1vknA:
undetectable		 3em3B-1vknA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.88A 3em6B-1vknA:
undetectable		 3em6B-1vknA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 HIS A 130
VAL A 266
ILE A 288
VAL A 286
THR A 148
 None
 0.73A 3fw3A-1vknA:
0.0		 3fw3A-1vknA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 11 PRO A 143
TYR A 242
ILE A 241
ILE A 288
PRO A 156
 None
 1.46A 3ganA-1vknA:
0.0		 3ganA-1vknA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.88A 3jvyB-1vknA:
undetectable		 3jvyB-1vknA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.85A 3k4vB-1vknA:
undetectable		 3k4vB-1vknA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.87A 3k4vC-1vknA:
undetectable		 3k4vC-1vknA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.89A 3nduC-1vknA:
undetectable		 3nduC-1vknA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 ALA A   4
ILE A   2
HIS A  24
VAL A 317
 None
 1.16A 3nneG-1vknA:
1.8		 3nneG-1vknA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		3 / 3 GLU A 128
LEU A 152
LEU A 269
 None
 0.77A 3ohtA-1vknA:
undetectable		 3ohtA-1vknA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		3 / 3 GLU A 128
LEU A 152
LEU A 269
 None
 0.77A 3ohtB-1vknA:
undetectable		 3ohtB-1vknA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 5 GLU A 328
LEU A 332
GLN A 315
GLY A 314
 None
 1.31A 3pp1A-1vknA:
0.8		 3pp1A-1vknA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.80A 3pwrB-1vknA:
undetectable		 3pwrB-1vknA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 ALA A  76
ASP A  93
TYR A 106
TYR A 117
 None
 1.20A 3rodD-1vknA:
undetectable		 3rodD-1vknA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.95A 3tkgD-1vknA:
undetectable		 3tkgD-1vknA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.85A 3tkwB-1vknA:
undetectable		 3tkwB-1vknA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.86A 3tl9B-1vknA:
undetectable		 3tl9B-1vknA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.08A 3wg7A-1vknA:
undetectable
3wg7C-1vknA:
undetectable
3wg7P-1vknA:
undetectable		 3wg7A-1vknA:
21.35
3wg7C-1vknA:
22.71
3wg7P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.07A 3wg7C-1vknA:
undetectable
3wg7N-1vknA:
undetectable
3wg7P-1vknA:
undetectable		 3wg7C-1vknA:
22.71
3wg7N-1vknA:
21.35
3wg7P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.04A 3x2qA-1vknA:
undetectable
3x2qC-1vknA:
undetectable
3x2qP-1vknA:
undetectable		 3x2qA-1vknA:
21.35
3x2qC-1vknA:
22.71
3x2qP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.04A 3x2qC-1vknA:
undetectable
3x2qN-1vknA:
undetectable
3x2qP-1vknA:
undetectable		 3x2qC-1vknA:
22.71
3x2qN-1vknA:
21.35
3x2qP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 VAL A 163
TYR A 242
LEU A 154
TYR A 256
 None
 1.03A 4b3qA-1vknA:
undetectable		 4b3qA-1vknA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 1.07A 4coxA-1vknA:
undetectable		 4coxA-1vknA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 1.07A 4coxB-1vknA:
undetectable		 4coxB-1vknA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 1.08A 4coxD-1vknA:
undetectable		 4coxD-1vknA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 TYR A 199
HIS A 206
TYR A 146
TYR A 187
 None
 1.35A 4df2A-1vknA:
undetectable		 4df2A-1vknA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.90A 4dqbA-1vknA:
undetectable		 4dqbA-1vknA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.88A 4dqfA-1vknA:
undetectable		 4dqfA-1vknA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 VAL A  63
SER A  33
TYR A  31
LEU A  82
 None
 0.91A 4hxyB-1vknA:
undetectable		 4hxyB-1vknA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		6 / 12 LEU A  70
ASP A  97
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 1.07A 4jecA-1vknA:
undetectable		 4jecA-1vknA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 1.10A 4otyA-1vknA:
undetectable		 4otyA-1vknA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 1.08A 4otyB-1vknA:
undetectable		 4otyB-1vknA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		3 / 3 PRO A 127
VAL A 266
HIS A 267
 None
 0.66A 4pevC-1vknA:
4.4		 4pevC-1vknA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 1.06A 4rrwC-1vknA:
undetectable		 4rrwC-1vknA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 1.02A 4rrwD-1vknA:
undetectable		 4rrwD-1vknA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 0.96A 4rrxA-1vknA:
undetectable		 4rrxA-1vknA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 0.94A 4rrxB-1vknA:
undetectable		 4rrxB-1vknA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 1.06A 4rrzC-1vknA:
undetectable		 4rrzC-1vknA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 1.02A 4rrzD-1vknA:
undetectable		 4rrzD-1vknA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.09A 5b1aA-1vknA:
undetectable
5b1aC-1vknA:
undetectable
5b1aP-1vknA:
undetectable		 5b1aA-1vknA:
21.35
5b1aC-1vknA:
22.71
5b1aP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.07A 5b1aN-1vknA:
undetectable
5b1aP-1vknA:
undetectable		 5b1aN-1vknA:
21.35
5b1aP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.12A 5b1bA-1vknA:
undetectable
5b1bC-1vknA:
undetectable
5b1bP-1vknA:
undetectable		 5b1bA-1vknA:
21.35
5b1bC-1vknA:
22.71
5b1bP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.10A 5b1bN-1vknA:
undetectable
5b1bP-1vknA:
undetectable		 5b1bN-1vknA:
21.35
5b1bP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.09A 5b3sA-1vknA:
undetectable
5b3sC-1vknA:
undetectable
5b3sP-1vknA:
undetectable		 5b3sA-1vknA:
21.35
5b3sC-1vknA:
22.71
5b3sP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.07A 5b3sN-1vknA:
undetectable
5b3sP-1vknA:
undetectable		 5b3sN-1vknA:
21.35
5b3sP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 0.95A 5ikqA-1vknA:
undetectable		 5ikqA-1vknA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 0.95A 5ikqB-1vknA:
undetectable		 5ikqB-1vknA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		3 / 3 TYR A  12
TYR A 199
SER A 174
 None
 0.70A 5iktB-1vknA:
undetectable		 5iktB-1vknA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.04A 5iy5A-1vknA:
undetectable
5iy5C-1vknA:
undetectable		 5iy5A-1vknA:
21.35
5iy5C-1vknA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.04A 5iy5C-1vknA:
undetectable
5iy5N-1vknA:
undetectable
5iy5P-1vknA:
undetectable		 5iy5C-1vknA:
22.44
5iy5N-1vknA:
21.35
5iy5P-1vknA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.78A 5kqyA-1vknA:
undetectable		 5kqyA-1vknA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 301
VAL A 170
ILE A 217
VAL A 243
ILE A 241
 None
 1.11A 5kqyA-1vknA:
undetectable		 5kqyA-1vknA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 TYR A 110
ARG A  99
ASP A  97
GLY A  77
 None
 1.27A 5mraA-1vknA:
undetectable
5mraB-1vknA:
undetectable		 5mraA-1vknA:
18.10
5mraB-1vknA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 ASN A 142
PRO A 143
GLU A 213
TYR A 117
 None
 1.09A 5oh1C-1vknA:
undetectable		 5oh1C-1vknA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 7 GLY A 215
LEU A 214
LEU A 162
ILE A 151
LEU A 129
 None
 1.27A 5vkqA-1vknA:
undetectable
5vkqB-1vknA:
undetectable		 5vkqA-1vknA:
11.71
5vkqB-1vknA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 8 GLY A 215
LEU A 214
LEU A 162
ILE A 151
LEU A 129
 None
 1.25A 5vkqB-1vknA:
undetectable
5vkqC-1vknA:
undetectable		 5vkqB-1vknA:
11.71
5vkqC-1vknA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.10A 5w97C-1vknA:
0.0
5w97a-1vknA:
undetectable
5w97c-1vknA:
0.0		 5w97C-1vknA:
22.71
5w97a-1vknA:
21.35
5w97c-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.08A 5wauC-1vknA:
0.0
5waua-1vknA:
undetectable
5wauc-1vknA:
0.0		 5wauC-1vknA:
22.71
5waua-1vknA:
21.35
5wauc-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.08A 5x19N-1vknA:
undetectable
5x19P-1vknA:
undetectable		 5x19N-1vknA:
21.35
5x19P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.09A 5x1bA-1vknA:
undetectable
5x1bC-1vknA:
0.0
5x1bP-1vknA:
undetectable		 5x1bA-1vknA:
21.35
5x1bC-1vknA:
22.71
5x1bP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.07A 5x1bN-1vknA:
undetectable
5x1bP-1vknA:
0.0		 5x1bN-1vknA:
21.35
5x1bP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.07A 5x1fA-1vknA:
undetectable
5x1fC-1vknA:
0.0
5x1fP-1vknA:
0.0		 5x1fA-1vknA:
21.35
5x1fC-1vknA:
22.71
5x1fP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.09A 5x1fN-1vknA:
undetectable
5x1fP-1vknA:
undetectable		 5x1fN-1vknA:
21.35
5x1fP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.06A 5xdqA-1vknA:
undetectable
5xdqC-1vknA:
undetectable
5xdqP-1vknA:
undetectable		 5xdqA-1vknA:
21.35
5xdqC-1vknA:
22.71
5xdqP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.04A 5xdqC-1vknA:
undetectable
5xdqN-1vknA:
undetectable
5xdqP-1vknA:
undetectable		 5xdqC-1vknA:
22.71
5xdqN-1vknA:
21.35
5xdqP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.08A 5xdxC-1vknA:
undetectable
5xdxN-1vknA:
undetectable
5xdxP-1vknA:
undetectable		 5xdxC-1vknA:
22.44
5xdxN-1vknA:
21.35
5xdxP-1vknA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.06A 5z84A-1vknA:
undetectable
5z84C-1vknA:
undetectable
5z84P-1vknA:
undetectable		 5z84A-1vknA:
21.35
5z84C-1vknA:
22.71
5z84P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.08A 5z84C-1vknA:
0.0
5z84N-1vknA:
undetectable
5z84P-1vknA:
0.0		 5z84C-1vknA:
22.71
5z84N-1vknA:
21.35
5z84P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.08A 5z85A-1vknA:
undetectable
5z85C-1vknA:
undetectable
5z85P-1vknA:
undetectable		 5z85A-1vknA:
21.35
5z85C-1vknA:
22.71
5z85P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.09A 5z85C-1vknA:
0.0
5z85N-1vknA:
undetectable
5z85P-1vknA:
0.0		 5z85C-1vknA:
22.71
5z85N-1vknA:
21.35
5z85P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.09A 5z86A-1vknA:
undetectable
5z86C-1vknA:
undetectable
5z86P-1vknA:
undetectable		 5z86A-1vknA:
21.35
5z86C-1vknA:
22.71
5z86P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.09A 5z86C-1vknA:
undetectable
5z86N-1vknA:
undetectable
5z86P-1vknA:
undetectable		 5z86C-1vknA:
22.71
5z86N-1vknA:
21.35
5z86P-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.06A 5zcoA-1vknA:
undetectable
5zcoC-1vknA:
undetectable
5zcoP-1vknA:
undetectable		 5zcoA-1vknA:
21.35
5zcoC-1vknA:
22.71
5zcoP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.10A 5zcoC-1vknA:
undetectable
5zcoN-1vknA:
undetectable
5zcoP-1vknA:
undetectable		 5zcoC-1vknA:
22.71
5zcoN-1vknA:
21.35
5zcoP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.08A 5zcpA-1vknA:
undetectable
5zcpC-1vknA:
undetectable
5zcpP-1vknA:
undetectable		 5zcpA-1vknA:
21.35
5zcpC-1vknA:
22.71
5zcpP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.10A 5zcpC-1vknA:
undetectable
5zcpN-1vknA:
undetectable
5zcpP-1vknA:
undetectable		 5zcpC-1vknA:
22.71
5zcpN-1vknA:
21.35
5zcpP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.07A 5zcqA-1vknA:
undetectable
5zcqC-1vknA:
undetectable
5zcqP-1vknA:
undetectable		 5zcqA-1vknA:
21.35
5zcqC-1vknA:
22.71
5zcqP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.07A 5zcqN-1vknA:
undetectable
5zcqP-1vknA:
undetectable		 5zcqN-1vknA:
21.35
5zcqP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.93A 6dh6A-1vknA:
undetectable		 6dh6A-1vknA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  70
VAL A 139
ILE A 120
VAL A  89
ILE A  91
 None
 0.94A 6difB-1vknA:
undetectable		 6difB-1vknA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.09A 6nknA-1vknA:
undetectable
6nknC-1vknA:
undetectable		 6nknA-1vknA:
21.35
6nknC-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.10A 6nknC-1vknA:
undetectable
6nknN-1vknA:
undetectable
6nknP-1vknA:
undetectable		 6nknC-1vknA:
22.71
6nknN-1vknA:
21.35
6nknP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.07A 6nmfA-1vknA:
undetectable
6nmfC-1vknA:
undetectable
6nmfP-1vknA:
undetectable		 6nmfA-1vknA:
21.35
6nmfC-1vknA:
22.71
6nmfP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.05A 6nmfN-1vknA:
undetectable
6nmfP-1vknA:
0.0		 6nmfN-1vknA:
21.35
6nmfP-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.01A 6nmpA-1vknA:
0.0
6nmpC-1vknA:
0.0		 6nmpA-1vknA:
21.35
6nmpC-1vknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 HIS A 285
ASP A 327
THR A 329
HIS A 267
 None
 1.06A 6nmpN-1vknA:
undetectable
6nmpP-1vknA:
undetectable		 6nmpN-1vknA:
21.35
6nmpP-1vknA:
22.71