SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 9 VAL A  70
GLY A  71
ASP A 148
ILE A 149
ALA A 237
 NAD  A 601 (-4.6A)
NAD  A 601 (-3.2A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.1A)
NAD  A 601 (-3.3A)
 0.48A 1cetA-1vkoA:
7.1		 1cetA-1vkoA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 SER A 315
SER A 429
ASN A  75
ASP A 348
 NAD  A 601 ( 2.8A)
K  A 526 (-3.1A)
NAD  A 601 (-3.6A)
NAD  A 601 (-3.1A)
 1.08A 1hwiB-1vkoA:
undetectable		 1hwiB-1vkoA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 SER A 315
SER A 429
ASN A  75
ASP A 348
 NAD  A 601 ( 2.8A)
K  A 526 (-3.1A)
NAD  A 601 (-3.6A)
NAD  A 601 (-3.1A)
 1.08A 1hwkA-1vkoA:
undetectable		 1hwkA-1vkoA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 SER A 315
SER A 429
ASN A  75
ASP A 348
 NAD  A 601 ( 2.8A)
K  A 526 (-3.1A)
NAD  A 601 (-3.6A)
NAD  A 601 (-3.1A)
 1.07A 1hwkC-1vkoA:
undetectable		 1hwkC-1vkoA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 SER A 315
SER A 429
ASN A  75
ASP A 348
 NAD  A 601 ( 2.8A)
K  A 526 (-3.1A)
NAD  A 601 (-3.6A)
NAD  A 601 (-3.1A)
 1.06A 1hwkD-1vkoA:
undetectable		 1hwkD-1vkoA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 GLY A  71
ASP A 148
ASN A  76
 NAD  A 601 (-3.2A)
NAD  A 601 (-2.7A)
NAD  A 601 ( 2.9A)
 0.51A 1vq1A-1vkoA:
undetectable		 1vq1A-1vkoA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 5 SER A 268
SER A 270
THR A 243
ASN A 291
 None
 1.41A 1yvpA-1vkoA:
2.6		 1yvpA-1vkoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 5 LEU A 500
GLY A  25
PRO A 135
VAL A 134
 None
 0.91A 2aojA-1vkoA:
undetectable		 2aojA-1vkoA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 9 LEU A  69
LEU A 234
ILE A 232
LEU A 142
ILE A 144
 None
 1.06A 2f78A-1vkoA:
undetectable		 2f78A-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 9 LEU A  69
LEU A 234
ILE A 232
LEU A 142
ILE A 144
 None
 1.11A 2f78B-1vkoA:
0.0		 2f78B-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 9 LEU A  69
LEU A 234
ILE A 232
LEU A 142
ILE A 144
 None
 1.10A 2f7aA-1vkoA:
0.6		 2f7aA-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 9 LEU A  69
LEU A  68
LEU A 234
LEU A 142
ILE A 144
 None
 1.18A 2f7aB-1vkoA:
0.9		 2f7aB-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 9 LEU A  69
LEU A 234
ILE A 232
LEU A 142
ILE A 144
 None
 1.04A 2f7aB-1vkoA:
0.9		 2f7aB-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 LEU A  69
LEU A 234
ILE A 232
LEU A 142
ILE A 144
 None
 1.07A 2f8dA-1vkoA:
undetectable		 2f8dA-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 LEU A  69
LEU A 234
ILE A 232
LEU A 142
ILE A 144
 None
 1.07A 2f8dB-1vkoA:
undetectable		 2f8dB-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 6 ASP A 311
PRO A 474
SER A 364
VAL A 368
 None
 1.17A 2hdnI-1vkoA:
undetectable
2hdnJ-1vkoA:
2.6
2hdnL-1vkoA:
2.0		 2hdnI-1vkoA:
4.88
2hdnJ-1vkoA:
22.52
2hdnL-1vkoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 6 SER A 364
VAL A 368
ASP A 311
PRO A 474
 None
 1.21A 2hdnJ-1vkoA:
2.6
2hdnK-1vkoA:
undetectable
2hdnL-1vkoA:
2.0		 2hdnJ-1vkoA:
22.52
2hdnK-1vkoA:
4.88
2hdnL-1vkoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 THR A 492
ASP A 371
SER A 375
 None
 0.82A 2nxeA-1vkoA:
1.8		 2nxeA-1vkoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 THR A 492
ASP A 371
SER A 375
 None
 0.76A 2nxeB-1vkoA:
2.1		 2nxeB-1vkoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 144
GLY A  77
PRO A 181
VAL A 180
ILE A 179
 None
 1.21A 2o4lA-1vkoA:
undetectable		 2o4lA-1vkoA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A  84
ALA A  80
LEU A  67
ILE A 441
LEU A 137
 None
 1.19A 2zzaA-1vkoA:
undetectable		 2zzaA-1vkoA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A  84
ALA A  80
LEU A  67
ILE A 441
LEU A 137
 None
 1.16A 2zzaB-1vkoA:
undetectable		 2zzaB-1vkoA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 GLY A  74
ASP A 148
SER A 150
 NAD  A 601 (-3.3A)
NAD  A 601 (-2.7A)
None
 0.41A 3brfA-1vkoA:
undetectable		 3brfA-1vkoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 136
LEU A 500
ALA A 501
ILE A 466
LEU A 493
 None
 1.03A 3dauA-1vkoA:
undetectable		 3dauA-1vkoA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 THR A  79
GLY A  82
ASN A  87
GLY A  73
LEU A 172
 None
None
None
NAD  A 601 (-4.3A)
None
 1.17A 3eeyF-1vkoA:
undetectable		 3eeyF-1vkoA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G59_A_ACTA306_0
(FMN
ADENYLYLTRANSFERASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 5 SER A 184
PHE A 273
ILE A 149
TRP A 235
 NAD  A 601 (-2.9A)
None
NAD  A 601 (-4.1A)
None
 1.26A 3g59A-1vkoA:
0.1		 3g59A-1vkoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 5 VAL A 233
LEU A  68
ILE A 215
ALA A 276
 None
 0.87A 3n8yB-1vkoA:
undetectable		 3n8yB-1vkoA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 PRO A 269
HIS A 211
SER A 184
ILE A 149
 None
None
NAD  A 601 (-2.9A)
NAD  A 601 (-4.1A)
 1.06A 3sfeB-1vkoA:
undetectable
3sfeC-1vkoA:
undetectable		 3sfeB-1vkoA:
17.22
3sfeC-1vkoA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 LYS A 402
SER A 340
GLN A 317
 POP  A 602 (-2.7A)
None
None
 1.32A 3si7A-1vkoA:
undetectable		 3si7A-1vkoA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 ALA A 432
PHE A 164
ASN A  76
ALA A  80
 NAD  A 601 (-3.5A)
None
NAD  A 601 ( 2.9A)
None
 0.84A 3t3sF-1vkoA:
undetectable		 3t3sF-1vkoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLY A  71
GLY A  73
ASP A 148
ALA A 237
ASN A 238
 NAD  A 601 (-3.2A)
NAD  A 601 (-4.3A)
NAD  A 601 (-2.7A)
NAD  A 601 (-3.3A)
NAD  A 601 (-3.5A)
 1.23A 3t7sA-1vkoA:
2.1		 3t7sA-1vkoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLY A  71
GLY A  73
ASP A 148
ALA A 237
ASN A 238
 NAD  A 601 (-3.2A)
NAD  A 601 (-4.3A)
NAD  A 601 (-2.7A)
NAD  A 601 (-3.3A)
NAD  A 601 (-3.5A)
 1.23A 3t7sB-1vkoA:
2.1		 3t7sB-1vkoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLY A  71
GLY A  73
ASP A 148
ALA A 237
ASN A 238
 NAD  A 601 (-3.2A)
NAD  A 601 (-4.3A)
NAD  A 601 (-2.7A)
NAD  A 601 (-3.3A)
NAD  A 601 (-3.5A)
 1.26A 3t7sD-1vkoA:
2.1		 3t7sD-1vkoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 9 THR A 292
LEU A 300
LEU A 297
GLY A 296
VAL A 267
 None
 1.43A 4c9kA-1vkoA:
undetectable		 4c9kA-1vkoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 9 THR A 292
LEU A 300
LEU A 297
GLY A 296
VAL A 267
 None
 1.41A 4c9kB-1vkoA:
undetectable		 4c9kB-1vkoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 SER A 259
ARG A 303
ILE A 256
GLU A 258
 None
 1.05A 4cx7A-1vkoA:
undetectable
4cx7B-1vkoA:
undetectable		 4cx7A-1vkoA:
20.76
4cx7B-1vkoA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 SER A 259
ARG A 303
ILE A 256
GLU A 258
 None
 1.11A 4cx7C-1vkoA:
undetectable
4cx7D-1vkoA:
undetectable		 4cx7C-1vkoA:
20.76
4cx7D-1vkoA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 LEU A 293
LEU A 297
ILE A 298
ARG A 303
GLY A 309
 None
 1.07A 4dm8B-1vkoA:
undetectable		 4dm8B-1vkoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 6 ILE A 466
THR A 492
VAL A 308
ASP A 311
 None
 1.17A 4iaqA-1vkoA:
0.3		 4iaqA-1vkoA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.98A 4jksA-1vkoA:
3.9		 4jksA-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.98A 4jksB-1vkoA:
4.1		 4jksB-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.98A 4jkuA-1vkoA:
4.3		 4jkuA-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.98A 4k8cA-1vkoA:
3.7		 4k8cA-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.98A 4k8cB-1vkoA:
4.1		 4k8cB-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.98A 4k8kA-1vkoA:
3.5		 4k8kA-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.98A 4k8kB-1vkoA:
3.4		 4k8kB-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.97A 4kahA-1vkoA:
3.6		 4kahA-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.97A 4kahB-1vkoA:
4.0		 4kahB-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.98A 4kalA-1vkoA:
4.0		 4kalA-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.98A 4kalB-1vkoA:
3.6		 4kalB-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 1.00A 4kanA-1vkoA:
4.3		 4kanA-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.99A 4kanB-1vkoA:
3.4		 4kanB-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.96A 4kbeA-1vkoA:
4.4		 4kbeA-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.97A 4kbeB-1vkoA:
3.6		 4kbeB-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 SER A 364
ASN A 238
ASN A 351
LEU A 352
ILE A 392
 None
NAD  A 601 (-3.5A)
None
None
None
 1.47A 4kukA-1vkoA:
undetectable		 4kukA-1vkoA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.99A 4lbgA-1vkoA:
3.5		 4lbgA-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.99A 4lbgB-1vkoA:
3.7		 4lbgB-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.98A 4lcaA-1vkoA:
4.1		 4lcaA-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASN A  76
ASP A 148
GLY A  73
GLY A  74
ILE A 149
 NAD  A 601 ( 2.9A)
NAD  A 601 (-2.7A)
NAD  A 601 (-4.3A)
NAD  A 601 (-3.3A)
NAD  A 601 (-4.1A)
 0.98A 4lcaB-1vkoA:
3.4		 4lcaB-1vkoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 5 ILE A 392
LEU A 352
ASP A 312
GLU A 362
 None
None
NAD  A 601 (-3.7A)
None
 0.89A 4nkxB-1vkoA:
0.0		 4nkxB-1vkoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 136
LEU A 500
ALA A 501
ILE A 466
LEU A 493
 None
 0.98A 4psyA-1vkoA:
undetectable		 4psyA-1vkoA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A  84
ALA A  80
LEU A  67
ILE A 441
LEU A 137
 None
 1.21A 4qlfA-1vkoA:
undetectable		 4qlfA-1vkoA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 SER A 367
ASP A 438
ASP A 312
 None
None
NAD  A 601 (-3.7A)
 0.75A 4uckA-1vkoA:
undetectable		 4uckA-1vkoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A  84
ALA A  80
LEU A  67
ILE A 441
LEU A 137
 None
 1.15A 5e8qB-1vkoA:
undetectable		 5e8qB-1vkoA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 278
GLU A 280
ARG A 216
ASN A 286
GLU A 240
 None
 1.29A 5fhzD-1vkoA:
undetectable		 5fhzD-1vkoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 SER A 277
ALA A 274
THR A 292
 None
 0.71A 5n0xB-1vkoA:
1.9		 5n0xB-1vkoA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 LYS A 314
LYS A 321
SER A 322
 None
 1.36A 5odiA-1vkoA:
4.0		 5odiA-1vkoA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 1vko INOSITOL-3-PHOSPHATE
SYNTHASE
(Caenorhabditis
elegans) 		4 / 6 ALA A 399
LEU A 430
THR A  79
ASN A  76
 None
None
None
NAD  A 601 ( 2.9A)
 0.97A 6f88B-1vkoA:
undetectable		 6f88B-1vkoA:
10.00