SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1vkw PUTATIVE
NITROREDUCTASE
(Thermotoga
maritima) 		3 / 3 ASP A  42
VAL A  97
PRO A  93
 None
 0.73A 2avvA-1vkwA:
undetectable		 2avvA-1vkwA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 1vkw PUTATIVE
NITROREDUCTASE
(Thermotoga
maritima) 		4 / 5 ILE A  75
PHE A 103
PHE A  84
ILE A  45
 None
 1.06A 2hjhA-1vkwA:
undetectable		 2hjhA-1vkwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1vkw PUTATIVE
NITROREDUCTASE
(Thermotoga
maritima) 		5 / 12 ILE A 192
GLU A  67
PHE A  70
LEU A 180
THR A  38
 None
 1.32A 2w3mB-1vkwA:
undetectable		 2w3mB-1vkwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 1vkw PUTATIVE
NITROREDUCTASE
(Thermotoga
maritima) 		4 / 8 ILE A 136
LEU A 161
LEU A 129
PRO A 206
 None
 0.79A 3ozwA-1vkwA:
undetectable		 3ozwA-1vkwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1vkw PUTATIVE
NITROREDUCTASE
(Thermotoga
maritima) 		4 / 5 VAL A 102
ILE A 118
PRO A 144
THR A 181
 None
None
SO4  A 208 ( 4.6A)
None
 1.33A 4ze1A-1vkwA:
undetectable		 4ze1A-1vkwA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1vkw PUTATIVE
NITROREDUCTASE
(Thermotoga
maritima) 		3 / 3 ARG A 195
PHE A  36
LEU A 175
 None
 0.85A 5veuA-1vkwA:
undetectable		 5veuA-1vkwA:
18.34