SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		4 / 6 LEU B 342
VAL B 393
VAL B 431
GLN B 381
 None
 0.85A 1e7aB-1vkxB:
1.0		 1e7aB-1vkxB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		4 / 7 GLN B 381
ALA B 435
PHE B 514
GLU B 346
 None
 1.39A 1t9wA-1vkxB:
undetectable		 1t9wA-1vkxB:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		5 / 12 ILE B 494
ALA B 497
ALA B 498
GLN B 501
LEU B 451
 None
 1.06A 1xiuB-1vkxB:
undetectable		 1xiuB-1vkxB:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		4 / 7 PRO B 380
LEU B 437
GLY B 438
LEU B 512
 None
 0.86A 1ya4B-1vkxB:
undetectable		 1ya4B-1vkxB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		5 / 6 PHE B 645
ILE B 566
PHE B 582
GLY B 562
GLY B 563
 None
 1.43A 2qx6A-1vkxB:
undetectable
2qx6B-1vkxB:
undetectable		 2qx6A-1vkxB:
23.27
2qx6B-1vkxB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		5 / 10 ILE B 494
ALA B 497
ALA B 498
GLN B 501
ILE B 460
 None
 1.13A 3falA-1vkxB:
undetectable		 3falA-1vkxB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		4 / 5 THR B 456
LYS B 491
GLU B 492
PHE B 448
 None
 1.23A 4ac9C-1vkxB:
2.2		 4ac9C-1vkxB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		4 / 5 THR B 456
LYS B 491
GLU B 492
PHE B 448
 None
 1.18A 4acaC-1vkxB:
2.2		 4acaC-1vkxB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		4 / 5 THR B 456
LYS B 491
GLU B 492
PHE B 448
 None
 1.17A 4acbC-1vkxB:
2.0		 4acbC-1vkxB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		5 / 9 GLY B 562
GLY B 563
PHE B 645
ILE B 566
PHE B 582
 None
 1.39A 4fgjA-1vkxB:
undetectable
4fgjB-1vkxB:
undetectable		 4fgjA-1vkxB:
23.44
4fgjB-1vkxB:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		5 / 11 PHE B 645
ILE B 566
PHE B 582
GLY B 562
GLY B 563
 None
 1.36A 4fglA-1vkxB:
undetectable
4fglB-1vkxB:
undetectable		 4fglA-1vkxB:
23.44
4fglB-1vkxB:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		4 / 6 PHE B 611
MET B 553
ILE B 580
VAL B 627
 None
 1.39A 4mk4B-1vkxB:
undetectable		 4mk4B-1vkxB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		3 / 3 VAL B 533
LEU B 451
MET B 455
 None
 0.81A 5ikrA-1vkxB:
undetectable		 5ikrA-1vkxB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		3 / 3 ARG B 356
ILE B 439
PHE B 355
 None
 0.70A 5kirA-1vkxB:
undetectable		 5kirA-1vkxB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		5 / 12 ILE B 494
ALA B 497
ALA B 498
GLN B 501
LEU B 451
 None
 1.05A 6a60D-1vkxB:
undetectable		 6a60D-1vkxB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)
(Mus
musculus) 		4 / 8 LEU B 512
LEU B 397
GLY B 365
ARG B 356
 None
 0.92A 6ce2A-1vkxB:
undetectable		 6ce2A-1vkxB:
24.05