SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		4 / 7 ASN A  59
LEU A 199
SER A  61
VAL A 201
 None
 1.12A 2uz2A-1vkyA:
undetectable		 2uz2A-1vkyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		4 / 8 LEU A 273
LEU A 301
ALA A 304
PHE A 281
 None
 0.78A 2vcvF-1vkyA:
undetectable		 2vcvF-1vkyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2001_1
(SERUM ALBUMIN)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		5 / 12 ARG A  96
PRO A  97
ILE A 109
ARG A  67
GLY A 142
 None
 1.38A 2vufB-1vkyA:
undetectable		 2vufB-1vkyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		5 / 12 PHE A  43
ALA A 286
ALA A 246
THR A 251
LEU A  58
 None
 1.20A 2x2nB-1vkyA:
undetectable		 2x2nB-1vkyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		5 / 12 PHE A  43
ALA A 286
ALA A 246
THR A 251
LEU A  58
 None
 1.20A 2x2nC-1vkyA:
0.0		 2x2nC-1vkyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		5 / 12 PHE A  43
ALA A 286
ALA A 246
THR A 251
LEU A  58
 None
 1.20A 2x2nD-1vkyA:
0.0		 2x2nD-1vkyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		3 / 3 PRO A  11
LEU A  14
ARG A  27
 None
 0.91A 3aqiA-1vkyA:
2.8		 3aqiA-1vkyA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		4 / 6 VAL A  60
GLN A 225
GLY A 269
LEU A 261
 None
 1.06A 3bjwE-1vkyA:
undetectable		 3bjwE-1vkyA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		4 / 6 TYR A 267
VAL A 231
THR A 254
THR A 251
 None
 1.03A 3tneA-1vkyA:
undetectable		 3tneA-1vkyA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		3 / 3 LYS A  76
PRO A  97
LYS A  72
 None
 1.19A 4dr5L-1vkyA:
0.0		 4dr5L-1vkyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		3 / 3 LYS A  76
PRO A  97
LYS A  72
 None
 1.23A 4dr6L-1vkyA:
0.0		 4dr6L-1vkyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		3 / 3 LYS A  76
PRO A  97
LYS A  72
 None
 1.12A 4duzL-1vkyA:
0.0		 4duzL-1vkyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		3 / 3 LYS A  76
PRO A  97
LYS A  72
 None
 1.35A 4dv7L-1vkyA:
0.5		 4dv7L-1vkyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		4 / 8 PRO A 277
LEU A 287
ILE A 334
LEU A 273
 None
 0.84A 5ieoA-1vkyA:
undetectable		 5ieoA-1vkyA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		4 / 4 LEU A  28
ARG A  44
ILE A  46
PHE A  43
 None
 1.02A 5kirB-1vkyA:
undetectable		 5kirB-1vkyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		3 / 3 GLU A  79
ARG A  67
TYR A  69
 None
 0.66A 5trqB-1vkyA:
0.0		 5trqB-1vkyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1vky S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE
(Thermotoga
maritima) 		4 / 7 PHE A   6
ARG A 295
LEU A 299
ALA A 303
 None
 1.28A 6b89A-1vkyA:
0.0		 6b89A-1vkyA:
17.04