SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 5 SER A 100
THR A 101
GLU A 133
GLY A 132
 None
NAI  A 300 (-4.0A)
None
None
 1.21A 1icrA-1vl0A:
undetectable
1icrB-1vl0A:
undetectable		 1icrA-1vl0A:
21.02
1icrB-1vl0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 5 GLU A 133
GLY A 132
SER A 100
THR A 101
 None
None
None
NAI  A 300 (-4.0A)
 1.20A 1icrA-1vl0A:
undetectable
1icrB-1vl0A:
undetectable		 1icrA-1vl0A:
21.02
1icrB-1vl0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 5 SER A 100
THR A 101
GLU A 133
GLY A 132
 None
NAI  A 300 (-4.0A)
None
None
 1.20A 1icvC-1vl0A:
undetectable
1icvD-1vl0A:
undetectable		 1icvC-1vl0A:
21.02
1icvD-1vl0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 5 GLU A 133
GLY A 132
SER A 100
THR A 101
 None
None
None
NAI  A 300 (-4.0A)
 1.20A 1icvC-1vl0A:
undetectable
1icvD-1vl0A:
undetectable		 1icvC-1vl0A:
21.02
1icvD-1vl0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 8 GLU A  95
ALA A  89
LEU A  85
THR A   6
 None
 0.93A 1ie4B-1vl0A:
undetectable
1ie4D-1vl0A:
undetectable		 1ie4B-1vl0A:
21.40
1ie4D-1vl0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 5 GLU A 133
GLY A 132
SER A 100
THR A 101
 None
None
None
NAI  A 300 (-4.0A)
 1.19A 1kqbA-1vl0A:
undetectable
1kqbB-1vl0A:
undetectable		 1kqbA-1vl0A:
24.83
1kqbB-1vl0A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 7 TYR A 144
LEU A 193
MET A   1
ILE A   3
 None
 0.82A 1tuvA-1vl0A:
undetectable		 1tuvA-1vl0A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 LEU A  85
VAL A  92
GLY A  93
LEU A   4
ILE A  28
 None
 0.75A 3ijdA-1vl0A:
undetectable		 3ijdA-1vl0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 LEU A  85
VAL A  92
GLY A  93
LEU A   4
ILE A  28
 None
 0.70A 3ijdB-1vl0A:
undetectable		 3ijdB-1vl0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 8 ASN A  57
ALA A  59
GLY A  13
ILE A  16
THR A  30
 None
NAI  A 300 (-3.2A)
None
None
None
 1.40A 3so9A-1vl0A:
undetectable		 3so9A-1vl0A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 5 SER A 100
ILE A  96
GLY A 132
PRO A  82
 None
 1.02A 3uboB-1vl0A:
3.8		 3uboB-1vl0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 LEU A  12
ILE A   3
ILE A  99
CYH A  58
ILE A 145
 NAI  A 300 (-4.5A)
None
NAI  A 300 (-4.2A)
None
None
 1.13A 3uj7A-1vl0A:
0.9		 3uj7A-1vl0A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ILE A 275
GLN A 279
ALA A 218
ILE A 227
PHE A 222
 None
 1.14A 4rp8C-1vl0A:
undetectable		 4rp8C-1vl0A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ILE A   3
ILE A  56
VAL A  27
ASN A   9
ALA A 189
 None
 1.09A 5lg3E-1vl0A:
undetectable		 5lg3E-1vl0A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 8 LEU A 172
VAL A 231
VAL A 229
ILE A 221
 None
 0.61A 5y9mA-1vl0A:
undetectable		 5y9mA-1vl0A:
15.97