SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		5 / 11 VAL A 208
VAL A  38
SER A  67
LEU A 131
ALA A 174
 None
 1.02A 1eqgB-1vl1A:
undetectable		 1eqgB-1vl1A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		4 / 7 TYR A 115
ASN A  80
HIS A 138
GLY A  42
 None
None
CIT  A 300 (-4.0A)
CIT  A 300 (-3.5A)
 1.25A 1mxgA-1vl1A:
undetectable		 1mxgA-1vl1A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		4 / 7 VAL A  38
VAL A 208
ALA A 140
LEU A 131
 None
 0.69A 1pthA-1vl1A:
undetectable		 1pthA-1vl1A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		4 / 7 VAL A  38
VAL A 208
ALA A 140
LEU A 131
 None
 0.70A 1pthB-1vl1A:
undetectable		 1pthB-1vl1A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		5 / 12 VAL A 165
VAL A 168
VAL A 102
LEU A  46
TYR A  49
 None
 1.07A 2cbrA-1vl1A:
undetectable		 2cbrA-1vl1A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		3 / 3 LYS A 190
ARG A 186
VAL A 218
 CIT  A 300 (-2.6A)
None
None
 1.09A 2r2vC-1vl1A:
0.0
2r2vD-1vl1A:
undetectable		 2r2vC-1vl1A:
11.31
2r2vD-1vl1A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		5 / 12 ILE A  94
ALA A  53
PHE A  89
ASN A  80
LEU A  66
 None
 1.21A 2w3mB-1vl1A:
undetectable		 2w3mB-1vl1A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		3 / 3 SER A  67
GLY A  41
GLY A 132
 None
 0.54A 3bogA-1vl1A:
undetectable
3bogC-1vl1A:
undetectable		 3bogA-1vl1A:
undetectable
3bogC-1vl1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		3 / 3 VAL A 208
VAL A  38
SER A  67
 None
 0.72A 3n8xB-1vl1A:
undetectable		 3n8xB-1vl1A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		5 / 10 TYR A  49
LEU A 175
VAL A 181
PHE A 183
VAL A 139
 None
 1.44A 3u9fK-1vl1A:
undetectable		 3u9fK-1vl1A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		5 / 9 TYR A  49
LEU A 175
VAL A 181
PHE A 183
VAL A 139
 None
 1.47A 3u9fP-1vl1A:
0.0		 3u9fP-1vl1A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		4 / 4 TYR A  49
THR A  44
VAL A  14
ILE A 130
 None
 0.95A 4jx1F-1vl1A:
undetectable		 4jx1F-1vl1A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1vl1 6-PHOSPHOGLUCONOLACT
ONASE
(Thermotoga
maritima) 		4 / 8 ARG A  43
LEU A  46
ASN A  83
ILE A  84
 None
 1.06A 4k0bA-1vl1A:
undetectable		 4k0bA-1vl1A:
24.08