SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 12 GLU A 281
ARG A 263
HIS A 188
VAL A 204
GLU A 202
 None
 1.45A 2qeoA-1vl2A:
undetectable		 2qeoA-1vl2A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		3 / 3 VAL A 343
ASN A  78
TRP A 289
 None
 1.09A 2y00B-1vl2A:
undetectable		 2y00B-1vl2A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		3 / 3 ASP A 122
GLU A 268
SER A  10
 None
 0.80A 3p2kA-1vl2A:
undetectable		 3p2kA-1vl2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		3 / 3 LEU A 307
HIS A 306
MET A 310
 None
 0.71A 3thrD-1vl2A:
undetectable		 3thrD-1vl2A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 5 TRP A 324
GLY A  88
ALA A  90
PHE A 315
 None
 1.14A 3wqwA-1vl2A:
undetectable		 3wqwA-1vl2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 8 ASN A 259
GLU A 218
ILE A 351
ASN A 235
 None
 1.11A 4d33A-1vl2A:
undetectable		 4d33A-1vl2A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 7 VAL A 356
VAL A 349
LEU A 221
ASN A  78
 None
 1.04A 4e1gB-1vl2A:
undetectable		 4e1gB-1vl2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 12 MET A 184
LEU A  76
ILE A  91
ILE A 319
LEU A  86
 None
 1.26A 4j24C-1vl2A:
undetectable		 4j24C-1vl2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 12 MET A 184
LEU A  76
ILE A  91
ILE A 319
LEU A  86
 None
 1.27A 4j26B-1vl2A:
undetectable		 4j26B-1vl2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 9 PRO A 168
ALA A 162
TYR A 161
GLY A  53
GLY A 166
 None
 1.22A 4mm5A-1vl2A:
undetectable		 4mm5A-1vl2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 9 PRO A 168
ALA A 162
TYR A 161
GLY A  53
GLY A 166
 None
 1.24A 4mmbA-1vl2A:
undetectable		 4mmbA-1vl2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 6 GLU A 296
THR A 299
GLN A 340
HIS A 224
 None
 1.28A 4pfjB-1vl2A:
3.5		 4pfjB-1vl2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		4 / 6 LEU A 221
ILE A 223
LEU A 252
TYR A 251
 None
 0.94A 4w5nA-1vl2A:
3.4		 4w5nA-1vl2A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1vl2 ARGININOSUCCINATE
SYNTHASE
(Thermotoga
maritima) 		5 / 12 PHE A  72
LEU A  86
ILE A 319
MET A 184
LEU A 248
 None
 1.49A 5ycpA-1vl2A:
0.0		 5ycpA-1vl2A:
10.93