SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 235
LEU A 403
LEU A 430
ILE A 396
ILE A 356
 None
 0.90A 2bxqA-1vl4A:
undetectable		 2bxqA-1vl4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 4 VAL A 225
TYR A 223
VAL A 432
SER A 397
 None
 1.44A 2x45B-1vl4A:
0.0		 2x45B-1vl4A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 346
ALA A 422
MET A 227
VAL A 427
LEU A 401
 None
 1.14A 3b0wB-1vl4A:
undetectable		 3b0wB-1vl4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		5 / 8 GLY A 327
ASP A 287
ASP A 286
THR A 312
ILE A 329
 None
 1.24A 3el0A-1vl4A:
undetectable		 3el0A-1vl4A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 5 SER A 368
GLY A 361
GLU A 358
GLU A 360
 None
 1.22A 3raeB-1vl4A:
undetectable
3raeD-1vl4A:
undetectable		 3raeB-1vl4A:
22.58
3raeD-1vl4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		5 / 11 PHE A 400
ILE A 243
ILE A 270
LEU A 336
VAL A 425
 None
 1.16A 3w67A-1vl4A:
undetectable		 3w67A-1vl4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		6 / 12 VAL A 427
PHE A 400
ILE A 243
ILE A 270
VAL A 268
VAL A 425
 None
 1.36A 3w68C-1vl4A:
undetectable		 3w68C-1vl4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		6 / 12 VAL A 263
PHE A 400
ILE A 243
ILE A 270
LEU A 336
VAL A 425
 None
 1.42A 3w68D-1vl4A:
undetectable		 3w68D-1vl4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 5 ASP A 166
GLU A 105
TYR A 107
GLU A 112
 None
 1.47A 3w9tA-1vl4A:
undetectable		 3w9tA-1vl4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 5 ASP A 166
GLU A 105
TYR A 107
GLU A 112
 None
 1.48A 3w9tC-1vl4A:
undetectable		 3w9tC-1vl4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 5 ASP A 166
GLU A 105
TYR A 107
GLU A 112
 None
 1.47A 3w9tD-1vl4A:
undetectable		 3w9tD-1vl4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 5 ASP A 166
GLU A 105
TYR A 107
GLU A 112
 None
 1.47A 3w9tG-1vl4A:
undetectable		 3w9tG-1vl4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		6 / 12 LEU A 336
ASP A 272
VAL A 297
ILE A 243
VAL A 268
ILE A 270
 None
 1.48A 4dqfA-1vl4A:
undetectable		 4dqfA-1vl4A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 5 SER A 215
LYS A 216
LEU A 212
ASP A 178
 None
 1.49A 4ifxA-1vl4A:
undetectable		 4ifxA-1vl4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 8 ILE A 240
GLU A 237
ILE A 421
LEU A 233
 None
 0.93A 4mj8A-1vl4A:
undetectable		 4mj8A-1vl4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		3 / 3 THR A 395
ASN A 399
PHE A 400
 None
 0.72A 4pd9A-1vl4A:
undetectable		 4pd9A-1vl4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 214
GLU A 360
ALA A 377
GLY A 379
TYR A 380
 None
 1.29A 4r29B-1vl4A:
undetectable		 4r29B-1vl4A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		3 / 3 GLU A 358
ILE A 201
ALA A 209
 None
 0.66A 4wnwB-1vl4A:
undetectable		 4wnwB-1vl4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 6 LEU A 235
LEU A 404
ILE A 240
PHE A 239
 None
 1.26A 4y4dA-1vl4A:
0.0		 4y4dA-1vl4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 6 PHE A   3
LYS A   7
LEU A  10
PRO A  72
 None
 1.45A 4yv5B-1vl4A:
undetectable		 4yv5B-1vl4A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 6 PHE A   3
LYS A   7
LEU A  10
PRO A  72
 None
 1.40A 4yv5A-1vl4A:
undetectable		 4yv5A-1vl4A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 7 ALA A 313
TYR A  93
VAL A 290
HIS A 308
 None
 1.09A 5ecnA-1vl4A:
undetectable		 5ecnA-1vl4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		3 / 3 ALA A  79
ASN A  82
LEU A  83
 None
 0.49A 5i1nC-1vl4A:
undetectable		 5i1nC-1vl4A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		3 / 3 ALA A  79
ASN A  82
LEU A  83
 None
 0.40A 5i1nB-1vl4A:
undetectable		 5i1nB-1vl4A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		3 / 3 ALA A  79
ASN A  82
LEU A  83
 None
 0.35A 5i1oC-1vl4A:
undetectable		 5i1oC-1vl4A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		3 / 3 ALA A  79
ASN A  82
LEU A  83
 None
 0.37A 5i1oA-1vl4A:
undetectable		 5i1oA-1vl4A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		3 / 3 ALA A  79
ASN A  82
LEU A  83
 None
 0.34A 5i1pD-1vl4A:
undetectable		 5i1pD-1vl4A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 6 PHE A 325
PRO A 331
THR A 321
ILE A 329
 None
 1.45A 5ih0A-1vl4A:
undetectable		 5ih0A-1vl4A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		5 / 10 ALA A 231
LEU A 235
LEU A 403
VAL A 425
ILE A 407
 None
 1.12A 5v02B-1vl4A:
undetectable
5v02R-1vl4A:
undetectable		 5v02B-1vl4A:
12.76
5v02R-1vl4A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 5 PRO A 338
GLY A 339
ASN A 412
LYS A 341
 None
 1.23A 5x23A-1vl4A:
undetectable		 5x23A-1vl4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 4 VAL A 225
LEU A 226
LEU A 346
ASP A 413
 None
 1.18A 5xv7A-1vl4A:
undetectable		 5xv7A-1vl4A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A 356
VAL A 427
LEU A 298
PHE A 239
LEU A 334
 None
 1.48A 6a7pB-1vl4A:
undetectable		 6a7pB-1vl4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A  83
THR A 156
ASN A 155
 None
 0.74A 6baaE-1vl4A:
undetectable		 6baaE-1vl4A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A  83
THR A 156
ASN A 155
 None
 0.74A 6baaF-1vl4A:
undetectable		 6baaF-1vl4A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A  83
THR A 156
ASN A 155
 None
 0.75A 6baaG-1vl4A:
undetectable		 6baaG-1vl4A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A  83
THR A 156
ASN A 155
 None
 0.74A 6baaH-1vl4A:
undetectable		 6baaH-1vl4A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1vl4 PMBA-RELATED PROTEIN
(Thermotoga
maritima) 		4 / 6 ASN A 197
PRO A 198
ILE A 201
GLU A 188
 None
 1.21A 6h7uA-1vl4A:
undetectable		 6h7uA-1vl4A:
21.89