SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vl8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 LEU A 226
ALA A 230
ALA A 234
THR A  90
VAL A  92
 None
 1.12A 1cbrA-1vl8A:
undetectable		 1cbrA-1vl8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 LEU A 226
ALA A 230
ALA A 234
THR A  90
VAL A  92
 None
 1.12A 1cbrB-1vl8A:
undetectable		 1cbrB-1vl8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 GLY A  22
LEU A  29
VAL A  36
ALA A  95
ASN A  93
 None
None
None
NAP  A 274 (-3.2A)
None
 1.20A 1fpqA-1vl8A:
6.0		 1fpqA-1vl8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 ALA A  94
ILE A  25
ILE A 188
ILE A 141
 NAP  A 274 (-4.5A)
None
None
None
 0.50A 1sh9A-1vl8A:
undetectable		 1sh9A-1vl8A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 GLY A  16
ARG A  41
ASP A  67
SER A  69
ALA A  95
 NAP  A 274 (-3.2A)
NAP  A 274 (-3.4A)
NAP  A 274 (-3.6A)
NAP  A 274 ( 4.7A)
NAP  A 274 (-3.2A)
 0.83A 2br4C-1vl8A:
4.4		 2br4C-1vl8A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 LEU A 226
ALA A 230
ALA A 234
THR A  90
VAL A  92
 None
 1.16A 3cwkA-1vl8A:
undetectable		 3cwkA-1vl8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		4 / 4 GLY A 191
TYR A 193
GLY A 221
ASP A 225
 None
 1.23A 3kl3A-1vl8A:
undetectable		 3kl3A-1vl8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 LEU A 226
ALA A 234
GLY A 145
PRO A 190
 None
None
None
NAP  A 274 (-3.8A)
 0.86A 3ny4A-1vl8A:
undetectable		 3ny4A-1vl8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 ASN A 186
ILE A 246
ALA A 234
VAL A  14
CYH A  34
 None
 1.07A 3rukA-1vl8A:
undetectable		 3rukA-1vl8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 TRP A 252
VAL A 248
TRP A 192
 None
 1.36A 3zq8A-1vl8A:
undetectable
3zq8B-1vl8A:
undetectable		 3zq8A-1vl8A:
3.00
3zq8B-1vl8A:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 ILE A 188
GLU A 236
ALA A  12
VAL A  14
LEU A  88
 None
 1.14A 5igpA-1vl8A:
undetectable		 5igpA-1vl8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 LEU A  77
GLU A  72
ASN A  93
VAL A  68
 None
None
None
NAP  A 274 (-3.6A)
 1.04A 5jh7C-1vl8A:
6.5		 5jh7C-1vl8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 GLY A  24
ILE A 188
ALA A  94
GLY A  16
ILE A 144
 None
None
NAP  A 274 (-4.5A)
NAP  A 274 (-3.2A)
NAP  A 274 (-4.4A)
 0.87A 5kb6A-1vl8A:
6.7		 5kb6A-1vl8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 GLY A  24
ILE A 188
ALA A  94
GLY A  16
ILE A 144
 None
None
NAP  A 274 (-4.5A)
NAP  A 274 (-3.2A)
NAP  A 274 (-4.4A)
 0.87A 5kb6B-1vl8A:
6.1		 5kb6B-1vl8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 LEU A 226
LYS A 227
ALA A 230
LEU A 233
 None
 0.87A 5vkqA-1vl8A:
undetectable
5vkqB-1vl8A:
undetectable		 5vkqA-1vl8A:
10.14
5vkqB-1vl8A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1vl8 GLUCONATE
5-DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 LEU A 226
LYS A 227
ALA A 230
LEU A 233
 None
 0.87A 5vkqC-1vl8A:
undetectable
5vkqD-1vl8A:
undetectable		 5vkqC-1vl8A:
10.14
5vkqD-1vl8A:
10.14