SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 MET A  97
GLU A 271
LEU A  69
ILE A  60
LEU A  53
 None
 1.42A 1a52A-1vlcA:
undetectable		 1a52A-1vlcA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 MET A  97
GLU A 271
LEU A  69
ILE A  60
LEU A  53
 None
 1.43A 1a52B-1vlcA:
undetectable		 1a52B-1vlcA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 PRO A 106
PHE A 303
LEU A 299
SER A 302
 None
 1.04A 1sbrA-1vlcA:
undetectable
1sbrB-1vlcA:
undetectable		 1sbrA-1vlcA:
18.40
1sbrB-1vlcA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 LEU A 259
ILE A 289
LEU A 119
PRO A 118
VAL A 116
 None
 1.13A 2po5A-1vlcA:
3.8		 2po5A-1vlcA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 11 SER A 263
LEU A  91
ALA A 273
MET A 240
GLU A 135
 None
 1.35A 2v0mA-1vlcA:
undetectable		 2v0mA-1vlcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		6 / 12 MET A  97
LEU A  98
GLU A 271
LEU A   6
LEU A  69
LEU A  53
 None
 1.50A 3erdA-1vlcA:
undetectable		 3erdA-1vlcA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 GLY A 343
GLN A 341
ILE A 289
VAL A 316
VAL A 319
 None
 1.01A 3fhjA-1vlcA:
undetectable		 3fhjA-1vlcA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 GLY A 343
GLN A 341
ILE A 289
VAL A 316
VAL A 319
 None
 1.00A 3fhjE-1vlcA:
undetectable		 3fhjE-1vlcA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 GLY A 343
GLN A 341
ILE A 289
VAL A 316
VAL A 319
 None
 1.04A 3fi0A-1vlcA:
undetectable		 3fi0A-1vlcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 GLY A 343
GLN A 341
ILE A 289
VAL A 316
VAL A 319
 None
 1.04A 3fi0H-1vlcA:
undetectable		 3fi0H-1vlcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 GLY A 343
GLN A 341
ILE A 289
VAL A 316
VAL A 319
 None
 1.08A 3fi0M-1vlcA:
undetectable		 3fi0M-1vlcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 GLY A 343
GLN A 341
ILE A 289
VAL A 316
VAL A 319
 None
 1.02A 3fi0N-1vlcA:
undetectable		 3fi0N-1vlcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 PRO A 106
SER A 261
LEU A 130
SER A 249
 None
 1.44A 3ijxH-1vlcA:
undetectable		 3ijxH-1vlcA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_2
(GLUTAMATE RECEPTOR 2)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 PRO A 106
SER A 261
LEU A 130
SER A 249
ASP A 247
 None
 1.48A 3tkdB-1vlcA:
undetectable		 3tkdB-1vlcA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 LEU A 130
THR A 237
THR A 183
VAL A 185
 None
 0.77A 4ik7A-1vlcA:
undetectable		 4ik7A-1vlcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 LEU A 130
THR A 237
THR A 183
VAL A 185
 None
 0.73A 4ik7B-1vlcA:
undetectable		 4ik7B-1vlcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 GLY A 257
ARG A 327
PRO A 272
ILE A  11
 None
 0.87A 4j4vC-1vlcA:
undetectable		 4j4vC-1vlcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 LEU A 136
ARG A 134
SER A 263
ALA A 290
GLU A 271
 None
 1.41A 4mx0A-1vlcA:
undetectable		 4mx0A-1vlcA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 VAL A  16
GLY A  12
ILE A  41
GLN A 291
LEU A  69
 None
 1.29A 4o5fA-1vlcA:
undetectable
4o5fB-1vlcA:
undetectable		 4o5fA-1vlcA:
24.48
4o5fB-1vlcA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 GLN A 291
LEU A  69
VAL A  16
GLY A  12
ILE A  41
 None
 1.27A 4o5fA-1vlcA:
undetectable
4o5fB-1vlcA:
undetectable		 4o5fA-1vlcA:
24.48
4o5fB-1vlcA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 ILE A  41
LEU A  53
GLY A  89
GLY A  90
 None
 0.71A 5a06A-1vlcA:
2.9		 5a06A-1vlcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 ILE A  41
LEU A  53
GLY A  89
GLY A  90
 None
 0.71A 5a06B-1vlcA:
undetectable		 5a06B-1vlcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 ILE A  41
LEU A  53
GLY A  89
GLY A  90
 None
 0.71A 5a06C-1vlcA:
2.9		 5a06C-1vlcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 GLU A  87
GLY A  42
GLY A  43
ASP A   9
 None
 1.00A 5a06D-1vlcA:
undetectable		 5a06D-1vlcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 ILE A  41
LEU A  53
GLY A  89
GLY A  90
 None
 0.71A 5a06E-1vlcA:
2.3		 5a06E-1vlcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 ILE A  41
LEU A  53
GLY A  89
GLY A  90
 None
 0.69A 5a06F-1vlcA:
2.3		 5a06F-1vlcA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 VAL A  16
GLY A  12
ILE A  41
GLN A 291
LEU A  69
 None
 1.31A 5b8hA-1vlcA:
undetectable
5b8hB-1vlcA:
undetectable		 5b8hA-1vlcA:
23.51
5b8hB-1vlcA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 LEU A  53
VAL A  72
GLY A   8
ASP A  44
GLY A  43
 None
 1.23A 5nnaA-1vlcA:
undetectable		 5nnaA-1vlcA:
20.74