SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vlm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 GLU A  26
TYR A  23
PHE A  49
 None
 0.96A 1eqbB-1vlmA:
undetectable		 1eqbB-1vlmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 GLU A  26
TYR A  23
PHE A  49
 None
 0.95A 1eqbD-1vlmA:
undetectable		 1eqbD-1vlmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A 123
LEU A 117
VAL A  59
LEU A  84
GLU A  82
 None
 1.14A 1sn5B-1vlmA:
undetectable
1sn5D-1vlmA:
undetectable		 1sn5B-1vlmA:
21.52
1sn5D-1vlmA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDA_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 10 VAL A  30
PHE A  49
VAL A 201
GLU A  26
THR A 176
 None
 1.42A 1ydaA-1vlmA:
undetectable		 1ydaA-1vlmA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A  43
GLY A  45
THR A  80
ALA A  81
GLU A  82
 NA  A 300 (-4.1A)
None
None
None
None
 0.45A 2gluA-1vlmA:
19.1		 2gluA-1vlmA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 GLY A  45
MET A  65
GLY A 126
PHE A  16
 None
 0.77A 2qwxA-1vlmA:
undetectable
2qwxB-1vlmA:
undetectable		 2qwxA-1vlmA:
23.21
2qwxB-1vlmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A  43
GLY A  45
GLU A  60
ALA A  81
PHE A  49
 NA  A 300 (-4.1A)
None
None
None
None
 1.15A 2vdvE-1vlmA:
9.2		 2vdvE-1vlmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 GLY A  43
GLY A  45
GLU A  60
ALA A  81
PHE A  49
 NA  A 300 (-4.1A)
None
None
None
None
 1.15A 2vdvF-1vlmA:
9.2		 2vdvF-1vlmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 GLU A  41
GLY A  43
GLY A  45
GLU A  60
ALA A  81
 None
NA  A 300 (-4.1A)
None
None
None
 0.70A 3dxyA-1vlmA:
10.7		 3dxyA-1vlmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 12 GLY A  43
GLY A  45
PRO A  61
ALA A  81
GLU A  82
PHE A  49
 NA  A 300 (-4.1A)
None
None
None
None
None
 1.16A 3mteB-1vlmA:
9.9		 3mteB-1vlmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 12 ALA A  50
GLY A 126
LEU A  95
THR A  46
GLY A  47
PHE A  16
 None
 1.27A 3mzeA-1vlmA:
undetectable		 3mzeA-1vlmA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A  43
GLY A  45
PRO A  61
ALA A  81
GLU A  82
 NA  A 300 (-4.1A)
None
None
None
None
 0.72A 3p2kB-1vlmA:
9.8		 3p2kB-1vlmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ILE A 100
GLY A 167
ALA A 166
LEU A 162
LEU A 159
 None
 0.99A 4o1zA-1vlmA:
undetectable		 4o1zA-1vlmA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 TYR A  12
GLY A  43
GLY A  45
SER A  62
MET A  65
 None
NA  A 300 (-4.1A)
None
None
None
 0.64A 4qtuD-1vlmA:
16.7		 4qtuD-1vlmA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 5 GLY A 193
GLY A 195
GLU A 196
 None
 0.51A 4z2eA-1vlmA:
undetectable
4z2eD-1vlmA:
undetectable		 4z2eA-1vlmA:
18.20
4z2eD-1vlmA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ILE A 124
ALA A  94
THR A  99
ILE A 100
LEU A 159
 None
None
NA  A 300 (-3.4A)
None
None
 1.10A 5e8qB-1vlmA:
2.3		 5e8qB-1vlmA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 MET A 163
ALA A 109
GLU A  82
ILE A 127
GLY A 126
 None
 1.15A 5gs4A-1vlmA:
undetectable		 5gs4A-1vlmA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ILE A  42
PRO A  85
LEU A  86
GLU A  82
HIS A   0
 None
 1.30A 5k7uA-1vlmA:
undetectable		 5k7uA-1vlmA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 LYS A   0
HIS A   3
HIS A   0
 None
 1.24A 5oexA-1vlmA:
undetectable		 5oexA-1vlmA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 LYS A   0
HIS A   3
HIS A   0
 None
 1.21A 5oexB-1vlmA:
undetectable		 5oexB-1vlmA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 LYS A   0
HIS A   3
HIS A   0
 None
 1.21A 5oexC-1vlmA:
undetectable		 5oexC-1vlmA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 LYS A   0
HIS A   3
HIS A   0
 None
 1.24A 5oexD-1vlmA:
undetectable		 5oexD-1vlmA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 9 LEU A 162
GLY A 204
ILE A 202
PHE A 171
ILE A 100
 None
 0.87A 6ebpA-1vlmA:
undetectable		 6ebpA-1vlmA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 10 LEU A 162
GLY A 204
ILE A 202
PHE A 171
ILE A 100
 None
 0.86A 6ebpB-1vlmA:
undetectable		 6ebpB-1vlmA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 10 LEU A 162
GLY A 204
ILE A 202
PHE A 171
ILE A 100
 None
 0.90A 6ebpC-1vlmA:
undetectable		 6ebpC-1vlmA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 10 LEU A 162
GLY A 204
ILE A 202
PHE A 171
ILE A 100
 None
 0.86A 6ebpD-1vlmA:
undetectable		 6ebpD-1vlmA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 LEU A 162
GLY A 204
ILE A 202
PHE A 171
ILE A 100
 None
 0.86A 6ebzA-1vlmA:
undetectable		 6ebzA-1vlmA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 LEU A 162
GLY A 204
ILE A 202
PHE A 171
ILE A 100
 None
 0.87A 6ebzB-1vlmA:
undetectable		 6ebzB-1vlmA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 LEU A 162
GLY A 204
ILE A 202
PHE A 171
ILE A 100
 None
 0.87A 6ebzC-1vlmA:
undetectable		 6ebzC-1vlmA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vlm SAM-DEPENDENT
METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 LEU A 162
GLY A 204
ILE A 202
PHE A 171
ILE A 100
 None
 0.85A 6ebzD-1vlmA:
undetectable		 6ebzD-1vlmA:
18.72