SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vlp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A  20
LEU A  73
LEU A  80
PRO A  81
 None
 1.12A 1hz4A-1vlpA:
undetectable		 1hz4A-1vlpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 232
SER A 297
ASP A 296
PHE A 278
 None
 1.09A 1ismB-1vlpA:
undetectable		 1ismB-1vlpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 7 PHE A 260
ALA A  22
ILE A  17
TYR A  84
ILE A 129
 None
 1.33A 1oniD-1vlpA:
undetectable
1oniF-1vlpA:
undetectable		 1oniD-1vlpA:
16.01
1oniF-1vlpA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 6 ARG A 180
SER A 214
GLY A 228
THR A 229
ARG A 294
 None
 0.83A 2f7fA-1vlpA:
2.2		 2f7fA-1vlpA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 135
PRO A 134
LEU A 138
 None
 0.59A 2po5B-1vlpA:
undetectable		 2po5B-1vlpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 330
ILE A 195
GLY A 212
ILE A 227
ILE A 353
 None
 1.11A 2r5qA-1vlpA:
undetectable		 2r5qA-1vlpA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 330
ILE A 195
GLY A 212
ILE A 227
ILE A 353
 None
 1.10A 2r5qC-1vlpA:
undetectable		 2r5qC-1vlpA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 136
ASP A  11
GLY A 178
GLY A 354
THR A 358
 None
None
None
PO4  A 500 (-3.1A)
None
 1.17A 2uvnA-1vlpA:
undetectable		 2uvnA-1vlpA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 239
GLY A 237
VAL A 383
ARG A 407
 None
 0.82A 2uyqA-1vlpA:
undetectable		 2uyqA-1vlpA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 8 SER A 175
GLN A 188
SER A 214
GLY A 354
GLY A 352
 None
None
None
PO4  A 500 (-3.1A)
None
 1.39A 2vinA-1vlpA:
undetectable		 2vinA-1vlpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  73
TYR A  72
GLN A  75
 None
 0.70A 2wekA-1vlpA:
undetectable		 2wekA-1vlpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 102
GLU A 382
ASP A 401
 None
 0.76A 2zulA-1vlpA:
undetectable		 2zulA-1vlpA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 358
PHE A 357
PHE A 174
GLU A 176
LEU A 210
 None
 1.34A 3apxA-1vlpA:
undetectable		 3apxA-1vlpA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 358
PHE A 357
PHE A 174
LEU A 210
ALA A 198
 None
 1.31A 3apxA-1vlpA:
undetectable		 3apxA-1vlpA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 102
GLU A 382
ASP A 401
 None
 0.79A 3dmhA-1vlpA:
2.1		 3dmhA-1vlpA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  22
THR A  25
CYH A 255
 None
 0.77A 3e4eB-1vlpA:
undetectable		 3e4eB-1vlpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 311
TYR A 303
GLY A 292
 None
 0.73A 3eteB-1vlpA:
undetectable
3eteD-1vlpA:
undetectable
3eteF-1vlpA:
undetectable		 3eteB-1vlpA:
23.19
3eteD-1vlpA:
23.19
3eteF-1vlpA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 387
ARG A 407
ASN A 386
GLU A 243
 None
 1.48A 3galA-1vlpA:
undetectable		 3galA-1vlpA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 387
ARG A 407
ASN A 386
GLU A 243
 None
 1.50A 3galB-1vlpA:
undetectable		 3galB-1vlpA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 373
GLY A 178
THR A 355
PHE A 218
ARG A 183
 None
None
PO4  A 500 (-4.1A)
None
None
 1.34A 3iv6C-1vlpA:
undetectable		 3iv6C-1vlpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 349
SER A 339
ILE A 172
GLY A 352
PHE A 351
 None
 1.24A 3nrrA-1vlpA:
undetectable		 3nrrA-1vlpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 290
GLY A 266
VAL A 230
THR A 229
 None
 1.07A 3tj7A-1vlpA:
undetectable
3tj7B-1vlpA:
undetectable		 3tj7A-1vlpA:
17.01
3tj7B-1vlpA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 290
GLY A 266
VAL A 230
THR A 229
 None
 1.07A 3tj7C-1vlpA:
undetectable
3tj7D-1vlpA:
undetectable		 3tj7C-1vlpA:
17.01
3tj7D-1vlpA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 230
THR A 229
TYR A 290
GLY A 266
 None
 1.10A 3tj7C-1vlpA:
undetectable
3tj7D-1vlpA:
undetectable		 3tj7C-1vlpA:
17.01
3tj7D-1vlpA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  95
LEU A 130
ILE A 378
ILE A 139
GLU A 233
 None
 1.42A 3tmzA-1vlpA:
0.0		 3tmzA-1vlpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  16
GLU A 233
TRP A 125
 None
 1.37A 3v4tH-1vlpA:
undetectable		 3v4tH-1vlpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 7 MET A 347
LEU A 348
SER A 321
HIS A 312
 None
 1.31A 4aq7A-1vlpA:
undetectable		 4aq7A-1vlpA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A  65
LEU A  95
HIS A  20
TYR A  84
 None
 1.01A 4f5zA-1vlpA:
undetectable		 4f5zA-1vlpA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  95
GLY A  61
ILE A 101
GLN A 100
 None
 1.12A 4ma8C-1vlpA:
1.1		 4ma8C-1vlpA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 330
ILE A 195
GLY A 212
ILE A 227
ILE A 353
 None
 1.06A 5kr1A-1vlpA:
undetectable		 5kr1A-1vlpA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 9 PRO A 300
TYR A 338
TYR A 303
THR A 304
ILE A 307
 None
 1.50A 5mvnB-1vlpA:
0.0		 5mvnB-1vlpA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 10 PRO A 300
TYR A 338
TYR A 303
THR A 304
ILE A 307
 None
 1.49A 5mvnD-1vlpA:
undetectable		 5mvnD-1vlpA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 216
LEU A  10
ARG A 180
LEU A 130
 None
 0.91A 5xdxA-1vlpA:
undetectable
5xdxJ-1vlpA:
undetectable		 5xdxA-1vlpA:
20.47
5xdxJ-1vlpA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 216
LEU A  10
ARG A 180
LEU A 130
 None
 0.94A 5xdxN-1vlpA:
0.0
5xdxW-1vlpA:
0.0		 5xdxN-1vlpA:
20.47
5xdxW-1vlpA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 176
ARG A 180
THR A  12
ILE A 216
 None
 1.06A 6a4iA-1vlpA:
0.0		 6a4iA-1vlpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  34
LEU A 380
ILE A 129
HIS A  20
TRP A 234
 None
 1.38A 6djzB-1vlpA:
0.0		 6djzB-1vlpA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 216
LEU A  10
ARG A 180
LEU A 130
 None
 0.93A 6nmpA-1vlpA:
0.0
6nmpJ-1vlpA:
undetectable		 6nmpA-1vlpA:
20.47
6nmpJ-1vlpA:
11.14