SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vlv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 ASP A 142
LEU A  25
ALA A 175
LEU A 172
 None
 0.96A 1nh8A-1vlvA:
1.1		 1nh8A-1vlvA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 LEU A 118
SER A 122
TYR A 121
LEU A  91
 None
 1.31A 1xz1A-1vlvA:
undetectable		 1xz1A-1vlvA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		5 / 10 ALA A  95
LEU A  91
LEU A 118
SER A   9
VAL A 126
 None
 1.17A 2bxeA-1vlvA:
undetectable		 2bxeA-1vlvA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 ARG A 108
PHE A  53
THR A  60
LEU A  62
 PO4  A 314 (-3.3A)
None
PO4  A 314 (-3.9A)
None
 1.26A 2e1qD-1vlvA:
undetectable		 2e1qD-1vlvA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		5 / 10 VAL A 307
ALA A 139
ARG A 300
TYR A 127
ILE A 304
 None
None
PO4  A 314 (-3.2A)
None
None
 1.39A 3retA-1vlvA:
undetectable
3retB-1vlvA:
undetectable		 3retA-1vlvA:
15.79
3retB-1vlvA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		5 / 7 LEU A 140
LEU A  25
GLU A  20
PRO A  18
ILE A  21
 None
 1.22A 3s56B-1vlvA:
undetectable		 3s56B-1vlvA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ASN A 149
GLY A 151
LEU A  25
ARG A  22
ILE A 268
 None
 1.27A 4p6xI-1vlvA:
undetectable		 4p6xI-1vlvA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 LEU A 273
ILE A 286
HIS A 271
VAL A 293
 None
 0.98A 4xyzA-1vlvA:
undetectable		 4xyzA-1vlvA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 GLU A  71
ALA A  67
GLU A  70
ASN A  35
 None
 1.34A 5dwkC-1vlvA:
undetectable		 5dwkC-1vlvA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 VAL A 156
ALA A 225
ILE A 268
THR A 267
 None
 1.06A 5e4dB-1vlvA:
0.0		 5e4dB-1vlvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ILE A 105
LEU A  10
LEU A  98
SER A   9
LEU A  85
 None
 1.17A 6b52A-1vlvA:
undetectable		 6b52A-1vlvA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 GLN A 138
VAL A 232
ARG A  61
ARG A 300
 None
None
None
PO4  A 314 (-3.2A)
 1.46A 6brdA-1vlvA:
0.4		 6brdA-1vlvA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		5 / 10 LEU A 118
VAL A 124
TYR A 121
GLY A  99
LEU A  91
 None
 1.47A 6bsjA-1vlvA:
0.7		 6bsjA-1vlvA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 SER A  57
HIS A 135
GLY A 129
ARG A 300
 PO4  A 314 (-2.7A)
PO4  A 314 (-4.1A)
None
PO4  A 314 (-3.2A)
 1.11A 6btxA-1vlvA:
undetectable		 6btxA-1vlvA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1vlv ORNITHINE
CARBAMOYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 LEU A 172
ASN A 149
LEU A 153
 None
 0.62A 6exiA-1vlvA:
8.7		 6exiA-1vlvA:
13.72