SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vm6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vm6 DIHYDRODIPICOLINATE
REDUCTASE
(Thermotoga
maritima) 		4 / 4 LEU A  54
VAL A  58
CYH A  61
ALA A  66
 None
 1.12A 1mz9E-1vm6A:
undetectable		 1mz9E-1vm6A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1vm6 DIHYDRODIPICOLINATE
REDUCTASE
(Thermotoga
maritima) 		5 / 12 PHE A  98
LEU A  68
ILE A  46
PHE A  48
SER A  49
 NAD  A 300 (-4.8A)
None
None
NAD  A 300 (-4.7A)
NAD  A 300 (-4.4A)
 1.01A 2lbdA-1vm6A:
undetectable		 2lbdA-1vm6A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1vm6 DIHYDRODIPICOLINATE
REDUCTASE
(Thermotoga
maritima) 		4 / 7 SER A  99
ILE A 102
PRO A 161
GLY A 162
 None
 0.94A 2y7kA-1vm6A:
undetectable		 2y7kA-1vm6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1vm6 DIHYDRODIPICOLINATE
REDUCTASE
(Thermotoga
maritima) 		4 / 5 ILE A 140
HIS A 164
GLU A 125
HIS A 127
 None
None
None
ACT  A 217 (-4.2A)
 0.97A 3ljgA-1vm6A:
2.8		 3ljgA-1vm6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 1vm6 DIHYDRODIPICOLINATE
REDUCTASE
(Thermotoga
maritima) 		4 / 6 HIS A 164
ARG A 156
HIS A 127
ASP A 133
 None
None
ACT  A 217 (-4.2A)
NAD  A 300 ( 3.9A)
 1.12A 3nvcA-1vm6A:
undetectable		 3nvcA-1vm6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vm6 DIHYDRODIPICOLINATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 LEU A  86
LEU A  83
LEU A  75
VAL A   6
 None
 0.82A 4klaA-1vm6A:
undetectable		 4klaA-1vm6A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 1vm6 DIHYDRODIPICOLINATE
REDUCTASE
(Thermotoga
maritima) 		4 / 8 TYR A   3
ILE A   5
ILE A  46
ALA A 191
 None
 0.87A 4ou1A-1vm6A:
undetectable		 4ou1A-1vm6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1vm6 DIHYDRODIPICOLINATE
REDUCTASE
(Thermotoga
maritima) 		5 / 10 VAL A  45
VAL A  90
TYR A  64
GLY A  67
LEU A  60
 None
 1.23A 6bsiA-1vm6A:
undetectable		 6bsiA-1vm6A:
15.79