SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vma'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 8 LEU A 227
ALA A 230
LYS A 231
LYS A 234
 None
 0.69A 1e7cA-1vmaA:
1.9		 1e7cA-1vmaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 LEU A 247
ARG A 280
ALA A 260
ILE A 218
ILE A 267
 None
 0.93A 1fk6A-1vmaA:
undetectable		 1fk6A-1vmaA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 7 LEU A  76
LEU A  71
TYR A  55
LEU A 257
 None
 1.05A 1kt3A-1vmaA:
undetectable		 1kt3A-1vmaA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 GLY A 254
GLY A 253
LEU A  11
LEU A 244
LEU A 247
 None
 1.07A 1mx1F-1vmaA:
undetectable		 1mx1F-1vmaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		6 / 11 ALA A 128
ASP A 129
ASP A 181
PRO A 211
VAL A  94
ILE A 180
 None
 1.46A 1ohrA-1vmaA:
undetectable		 1ohrA-1vmaA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		6 / 12 ALA A 128
ASP A 129
ASP A 181
PRO A 211
VAL A  94
ILE A 180
 None
 1.48A 2avoB-1vmaA:
undetectable		 2avoB-1vmaA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		6 / 12 ALA A 128
ASP A 129
ASP A 181
PRO A 211
VAL A  94
ILE A 180
 None
 1.50A 2avvB-1vmaA:
undetectable		 2avvB-1vmaA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		6 / 12 ALA A 128
ASP A 129
ASP A 181
PRO A 211
VAL A  94
ILE A 180
 None
 1.49A 2bpxB-1vmaA:
undetectable		 2bpxB-1vmaA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 8 VAL A 123
VAL A 117
LEU A 125
ASP A 118
 None
 1.03A 2ddwA-1vmaA:
undetectable		 2ddwA-1vmaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 LEU A 291
PHE A 287
ILE A 267
ILE A 218
ILE A 255
 None
 1.32A 2efjA-1vmaA:
undetectable		 2efjA-1vmaA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		6 / 12 ALA A 128
ASP A 129
PHE A 233
PRO A 211
VAL A  94
ILE A 180
 None
 1.39A 2fxeA-1vmaA:
undetectable		 2fxeA-1vmaA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 LEU A 291
PHE A 287
LEU A 292
ILE A 255
LEU A  60
 None
 1.18A 2hrcA-1vmaA:
undetectable		 2hrcA-1vmaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 LEU A 291
PHE A 287
LEU A 292
ILE A 255
LEU A  60
 None
 1.23A 2po7B-1vmaA:
2.8		 2po7B-1vmaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		6 / 12 ALA A 128
ASP A 129
ASP A 181
PRO A 211
VAL A  94
ILE A 180
 None
 1.49A 2r5pB-1vmaA:
undetectable		 2r5pB-1vmaA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		6 / 12 ALA A 128
ASP A 129
ASP A 181
PRO A 211
VAL A  94
ILE A 180
 None
 1.49A 2r5pD-1vmaA:
undetectable		 2r5pD-1vmaA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 5 PHE A  18
PHE A  19
LEU A 291
PHE A 287
 None
 1.37A 2y69C-1vmaA:
0.2
2y69J-1vmaA:
0.0		 2y69C-1vmaA:
21.88
2y69J-1vmaA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 11 ILE A 259
LEU A 215
ASN A  86
LEU A 244
THR A 103
 None
 1.18A 3a50B-1vmaA:
2.2		 3a50B-1vmaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 11 ILE A 259
LEU A 215
ASN A  86
LEU A 244
THR A 103
 None
 1.17A 3a50C-1vmaA:
2.4		 3a50C-1vmaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 11 LEU A 215
ASN A  86
LEU A 244
ILE A 243
THR A 103
 None
 1.19A 3a50C-1vmaA:
2.4		 3a50C-1vmaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 ILE A 259
LEU A 215
ASN A  86
LEU A 244
THR A 103
 None
 1.13A 3a50E-1vmaA:
undetectable		 3a50E-1vmaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 5 PHE A  18
PHE A  19
LEU A 291
PHE A 287
 None
 1.38A 3abmC-1vmaA:
0.2
3abmJ-1vmaA:
0.0		 3abmC-1vmaA:
21.88
3abmJ-1vmaA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 8 ILE A 255
PHE A  81
PHE A 287
PHE A 282
 None
 0.89A 3ko0B-1vmaA:
2.5
3ko0J-1vmaA:
2.6		 3ko0B-1vmaA:
14.05
3ko0J-1vmaA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 8 GLY A  10
ILE A 255
PHE A  81
PHE A 287
 None
 0.97A 3ko0K-1vmaA:
2.4
3ko0S-1vmaA:
2.6		 3ko0K-1vmaA:
14.05
3ko0S-1vmaA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 8 PHE A 287
PHE A 282
ILE A 255
PHE A  81
 None
 0.93A 3ko0O-1vmaA:
2.4
3ko0Q-1vmaA:
2.5		 3ko0O-1vmaA:
14.05
3ko0Q-1vmaA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 8 LEU A  71
SER A  70
LEU A  79
ARG A  59
ILE A  56
 None
 1.37A 3ln1A-1vmaA:
undetectable		 3ln1A-1vmaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 8 LEU A  79
LEU A   7
ILE A 267
PHE A 282
 None
 0.90A 3ln1A-1vmaA:
undetectable		 3ln1A-1vmaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 7 LEU A  71
SER A  70
LEU A  79
ARG A  59
ILE A  56
 None
 1.36A 3ln1B-1vmaA:
undetectable		 3ln1B-1vmaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 7 LEU A  79
LEU A   7
ILE A 267
PHE A 282
 None
 0.91A 3ln1B-1vmaA:
undetectable		 3ln1B-1vmaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 ILE A  78
ALA A 258
LEU A 257
LEU A  71
LEU A  42
 None
 1.04A 3ozuA-1vmaA:
2.6		 3ozuA-1vmaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 4 ASP A 129
ASP A 181
GLY A  99
THR A 214
 None
 0.90A 3tl9B-1vmaA:
undetectable		 3tl9B-1vmaA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 8 LEU A 291
LYS A  72
VAL A  23
LEU A 257
 None
 1.05A 3v81A-1vmaA:
2.3		 3v81A-1vmaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 8 ALA A 128
ASP A 129
ASP A 181
PRO A 211
 None
 0.81A 4eyrB-1vmaA:
undetectable		 4eyrB-1vmaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 11 HIS A 153
VAL A 203
ILE A 151
LEU A 139
ALA A 170
 None
 1.25A 4m83A-1vmaA:
undetectable		 4m83A-1vmaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 LEU A 216
LEU A 244
THR A 221
ALA A 230
ILE A 255
 None
 0.89A 4x20B-1vmaA:
3.7		 4x20B-1vmaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 7 VAL A  94
ILE A 180
VAL A 203
ILE A 207
 None
 0.76A 5bmvC-1vmaA:
4.1		 5bmvC-1vmaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 LEU A 244
LEU A 292
THR A  14
ALA A  46
LEU A  43
 None
 1.07A 5iepA-1vmaA:
undetectable		 5iepA-1vmaA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		6 / 12 ILE A 207
PRO A  92
ALA A 127
ALA A 126
VAL A 124
LEU A 139
 None
 1.38A 5igpA-1vmaA:
undetectable		 5igpA-1vmaA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		6 / 12 ILE A 207
PRO A  92
ALA A 127
ALA A 126
VAL A 124
LEU A 139
 None
 1.38A 5igtA-1vmaA:
undetectable		 5igtA-1vmaA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		4 / 8 VAL A  48
ILE A  78
LEU A 257
ILE A  75
 None
 0.71A 5numA-1vmaA:
undetectable		 5numA-1vmaA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 VAL A 288
VAL A  48
LEU A  57
LEU A  39
VAL A  22
 None
 1.04A 5tudA-1vmaA:
undetectable		 5tudA-1vmaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 LEU A 216
LEU A 244
THR A 221
ALA A 230
ILE A 255
 None
 1.01A 5xiwB-1vmaA:
4.0		 5xiwB-1vmaA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 1vma CELL DIVISION
PROTEIN FTSY
(Thermotoga
maritima) 		5 / 12 LEU A  79
THR A 256
LEU A 292
LEU A 291
PHE A 282
 None
 1.50A 6gbnC-1vmaA:
undetectable		 6gbnC-1vmaA:
22.00