SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 12 HIS A 228
HIS A  90
GLU A  87
HIS A  85
ASP A 168
 FEO  A 401 (-3.3A)
FEO  A 401 (-3.3A)
FEO  A 401 (-2.9A)
FEO  A 401 (-3.4A)
FEO  A 401 (-2.5A)
 1.34A 1a4lD-1vmeA:
undetectable		 1a4lD-1vmeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 4 HIS A 103
LEU A  69
LEU A  44
LEU A  47
 None
 1.23A 1a4lD-1vmeA:
undetectable		 1a4lD-1vmeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 8 ASP A 168
HIS A  85
HIS A  90
HIS A 151
 FEO  A 401 (-2.5A)
FEO  A 401 (-3.4A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.5A)
 0.78A 1ei6D-1vmeA:
1.6		 1ei6D-1vmeA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		3 / 3 TRP A  57
TYR A  43
LEU A  53
 None
 1.07A 1kxhA-1vmeA:
undetectable		 1kxhA-1vmeA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		3 / 3 ILE A  66
LEU A  69
VAL A  73
 None
 0.42A 1mz9B-1vmeA:
undetectable		 1mz9B-1vmeA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 247
SER A 245
GLY A 172
LEU A 150
TYR A 190
 None
 1.07A 1nbhB-1vmeA:
undetectable		 1nbhB-1vmeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 6 LYS A  46
LEU A  44
LEU A  53
THR A  79
 None
 1.27A 1tyrA-1vmeA:
undetectable		 1tyrA-1vmeA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 4 ILE A  82
ASP A 161
LEU A 164
ARG A 135
 None
 1.22A 2a7qA-1vmeA:
4.3		 2a7qA-1vmeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A 165
GLY A 227
GLY A 171
ILE A  15
TYR A 197
 None
 1.10A 2hmyB-1vmeA:
5.8		 2hmyB-1vmeA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 11 ASP A  89
HIS A  90
HIS A 151
ASP A 168
HIS A 228
 FEO  A 401 (-2.4A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.5A)
FEO  A 401 (-2.5A)
FEO  A 401 (-3.3A)
 0.99A 2q0jB-1vmeA:
20.2		 2q0jB-1vmeA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		3 / 3 TYR A 190
TYR A 243
GLY A 172
 None
 0.62A 3eteB-1vmeA:
4.1
3eteD-1vmeA:
2.5
3eteF-1vmeA:
2.5		 3eteB-1vmeA:
22.11
3eteD-1vmeA:
22.11
3eteF-1vmeA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		3 / 3 TYR A 243
TYR A 190
GLY A 170
 None
 0.55A 3eteB-1vmeA:
4.1
3eteD-1vmeA:
2.5
3eteF-1vmeA:
2.5		 3eteB-1vmeA:
22.11
3eteD-1vmeA:
22.11
3eteF-1vmeA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 12 MET A 263
GLY A 314
VAL A 345
MET A 326
ILE A 322
 None
 1.21A 3h52A-1vmeA:
undetectable		 3h52A-1vmeA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 190
GLU A  36
LEU A 191
TRP A 232
 None
 1.33A 3k8mB-1vmeA:
undetectable		 3k8mB-1vmeA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A  68
TYR A  16
LEU A  44
ILE A 101
LYS A  46
 None
 1.40A 3qt0A-1vmeA:
undetectable		 3qt0A-1vmeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 6 LYS A  46
LEU A  44
LEU A  53
THR A  79
 None
 1.12A 4d7bB-1vmeA:
undetectable		 4d7bB-1vmeA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 229
GLY A 171
LEU A 224
ILE A  38
ILE A 231
 None
 1.11A 4qtuB-1vmeA:
undetectable		 4qtuB-1vmeA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 6 ALA A 274
GLY A 314
ILE A 390
VAL A 343
 None
 0.82A 4r21A-1vmeA:
undetectable		 4r21A-1vmeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 9 ALA A 274
ILE A 259
GLY A 314
ILE A 390
VAL A 343
 None
 0.99A 4r21B-1vmeA:
undetectable		 4r21B-1vmeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 8 SER A  91
TYR A 121
GLY A  92
ILE A  25
 None
 0.86A 5alcL-1vmeA:
undetectable		 5alcL-1vmeA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 6 ASP A 168
HIS A  90
HIS A 228
HIS A 151
 FEO  A 401 (-2.5A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.5A)
 0.83A 5ncdA-1vmeA:
undetectable
5ncdD-1vmeA:
undetectable		 5ncdA-1vmeA:
20.59
5ncdD-1vmeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 6 ASP A 168
HIS A  90
HIS A 228
HIS A 151
 FEO  A 401 (-2.5A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.5A)
 0.87A 5ncdB-1vmeA:
undetectable
5ncdC-1vmeA:
undetectable		 5ncdB-1vmeA:
20.59
5ncdC-1vmeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 6 ASP A 168
HIS A  90
HIS A 228
HIS A 151
 FEO  A 401 (-2.5A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.5A)
 0.83A 5nelA-1vmeA:
undetectable
5nelD-1vmeA:
undetectable		 5nelA-1vmeA:
20.59
5nelD-1vmeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O45_B_CCSB13_0
(PHE-MEA-9KK-SAR-ASP-
VAL-MEA-TYR-SAR-TRP-
TYR-LEU-CCS-GLY-NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 9 ASN A  84
VAL A 157
PHE A 165
TYR A  43
GLY A 227
 None
 1.10A 5o45A-1vmeA:
0.0
5o45B-1vmeA:
undetectable		 5o45A-1vmeA:
15.66
5o45B-1vmeA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 6 VAL A 258
ILE A 275
LYS A 289
TYR A 260
 None
 1.50A 5q1sA-1vmeA:
8.8		 5q1sA-1vmeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A  15
PHE A 165
ALA A  42
ASP A  55
ILE A 231
 None
 1.07A 6dwnD-1vmeA:
undetectable		 6dwnD-1vmeA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 11 PHE A 165
GLY A 227
PHE A  10
ILE A  15
ILE A   9
 None
 1.06A 6ebzA-1vmeA:
undetectable		 6ebzA-1vmeA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 11 PHE A 165
GLY A 227
PHE A  10
ILE A  15
ILE A   9
 None
 1.06A 6ebzB-1vmeA:
undetectable		 6ebzB-1vmeA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 11 PHE A 165
GLY A 227
PHE A  10
ILE A  15
ILE A   9
 None
 1.06A 6ebzC-1vmeA:
undetectable		 6ebzC-1vmeA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 11 PHE A 165
GLY A 227
PHE A  10
ILE A  15
ILE A   9
 None
 1.07A 6ebzD-1vmeA:
undetectable		 6ebzD-1vmeA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		3 / 3 TYR A  40
HIS A 228
PHE A  28
 None
FEO  A 401 (-3.3A)
None
 1.05A 6esmA-1vmeA:
2.8		 6esmA-1vmeA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 10 VAL A 246
LEU A 239
GLY A 203
GLY A 170
VAL A 194
 None
 1.09A 6eu9B-1vmeA:
0.0		 6eu9B-1vmeA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 10 VAL A 246
LEU A 239
GLY A 203
GLY A 171
VAL A 194
 None
 0.99A 6eu9B-1vmeA:
0.0		 6eu9B-1vmeA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 5 LEU A 239
TYR A 243
ILE A  82
GLY A 172
 None
 1.05A 6hd6A-1vmeA:
undetectable		 6hd6A-1vmeA:
12.75