SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vol'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1vol PROTEIN
(TRANSCRIPTION
FACTOR IIB (TFIIB))
(Homo
sapiens) 		4 / 5 VAL A 253
SER A 288
GLY A 247
ARG A 248
 None
 1.18A 3v4tA-1volA:
undetectable
3v4tD-1volA:
undetectable		 3v4tA-1volA:
19.08
3v4tD-1volA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1vol PROTEIN
(TRANSCRIPTION
FACTOR IIB (TFIIB))
(Homo
sapiens) 		4 / 6 CYH A 194
ILE A 198
ILE A 186
ASP A 157
 None
 1.20A 4w5tA-1volA:
undetectable		 4w5tA-1volA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1vol PROTEIN
(TRANSCRIPTION
FACTOR IIB (TFIIB))
(Homo
sapiens) 		4 / 6 CYH A 194
ILE A 198
ILE A 186
ASP A 157
 None
 1.22A 4z4dA-1volA:
undetectable		 4z4dA-1volA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1vol PROTEIN
(TRANSCRIPTION
FACTOR IIB (TFIIB))
(Homo
sapiens) 		5 / 12 ASP A 157
ALA A 155
GLY A 192
SER A 161
TYR A 165
 None
 1.36A 5hfjA-1volA:
undetectable		 5hfjA-1volA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 1vol PROTEIN
(TRANSCRIPTION
FACTOR IIB (TFIIB))
(Homo
sapiens) 		5 / 11 ASP A 243
LEU A 299
LEU A 291
ARG A 295
PRO A 294
 None
 1.47A 6fgcA-1volA:
undetectable		 6fgcA-1volA:
17.91