SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1vp2 PUTATIVE XANTHOSINE
TRIPHOSPHATE
PYROPHOSPHATASE/HAM1
PROTEIN HOMOLOG
(Thermotoga
maritima) 		4 / 7 SER A 129
ALA A  66
SER A 116
THR A 118
 None
 0.80A 3cfqA-1vp2A:
undetectable
3cfqB-1vp2A:
undetectable		 3cfqA-1vp2A:
20.48
3cfqB-1vp2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1vp2 PUTATIVE XANTHOSINE
TRIPHOSPHATE
PYROPHOSPHATASE/HAM1
PROTEIN HOMOLOG
(Thermotoga
maritima) 		4 / 7 TYR A 150
ARG A 176
ASN A  12
ALA A  85
 None
 1.31A 3frqB-1vp2A:
undetectable		 3frqB-1vp2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 1vp2 PUTATIVE XANTHOSINE
TRIPHOSPHATE
PYROPHOSPHATASE/HAM1
PROTEIN HOMOLOG
(Thermotoga
maritima) 		4 / 8 HIS A  62
PHE A 119
PRO A  24
TRP A  26
 None
 1.21A 3v35A-1vp2A:
undetectable		 3v35A-1vp2A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1vp2 PUTATIVE XANTHOSINE
TRIPHOSPHATE
PYROPHOSPHATASE/HAM1
PROTEIN HOMOLOG
(Thermotoga
maritima) 		4 / 8 ALA A  66
SER A 116
THR A 118
SER A 129
 None
 0.81A 4ikkA-1vp2A:
undetectable
4ikkB-1vp2A:
undetectable		 4ikkA-1vp2A:
20.48
4ikkB-1vp2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 1vp2 PUTATIVE XANTHOSINE
TRIPHOSPHATE
PYROPHOSPHATASE/HAM1
PROTEIN HOMOLOG
(Thermotoga
maritima) 		4 / 5 ASP A 151
PHE A 154
PHE A 163
VAL A 134
 None
 1.12A 5a1rA-1vp2A:
undetectable		 5a1rA-1vp2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1vp2 PUTATIVE XANTHOSINE
TRIPHOSPHATE
PYROPHOSPHATASE/HAM1
PROTEIN HOMOLOG
(Thermotoga
maritima) 		4 / 8 ILE A  36
ALA A  66
VAL A  64
VAL A  38
 None
 0.66A 5ecnD-1vp2A:
undetectable		 5ecnD-1vp2A:
15.75