SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vp5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		5 / 10 THR A 214
ALA A 216
PHE A 191
VAL A   3
TYR A  41
 None
NAP  A 300 (-3.1A)
NAP  A 300 (-4.5A)
None
None
 1.29A 1claA-1vp5A:
undetectable		 1claA-1vp5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		4 / 5 LEU A  43
ASP A  45
VAL A 229
ILE A 231
 None
NAP  A 300 (-3.7A)
None
NAP  A 300 (-4.7A)
 0.95A 2aoiB-1vp5A:
undetectable		 2aoiB-1vp5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		3 / 3 ARG A 135
THR A   7
VAL A  12
 None
 0.97A 2q64A-1vp5A:
undetectable		 2q64A-1vp5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 150
HIS A 119
ASP A 149
GLY A 116
PHE A 142
 None
 1.39A 2zj0A-1vp5A:
2.3		 2zj0A-1vp5A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 150
HIS A 119
ASP A 149
GLY A 116
PHE A 142
 None
 1.37A 3ce6A-1vp5A:
2.4		 3ce6A-1vp5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		5 / 12 ASP A 255
LEU A 251
THR A 214
SER A 245
GLN A 217
 None
 1.49A 3g4lD-1vp5A:
undetectable		 3g4lD-1vp5A:
23.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		5 / 12 TYR A  50
TRP A  81
HIS A 112
ASN A 141
PHE A 270
 NAP  A 300 (-4.9A)
None
NAP  A 300 (-4.5A)
NAP  A 300 (-3.1A)
None
 0.94A 3ug8A-1vp5A:
39.5		 3ug8A-1vp5A:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		4 / 8 THR A  46
LEU A 103
LEU A 101
GLY A  57
 None
 0.80A 4c9nA-1vp5A:
undetectable		 4c9nA-1vp5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		4 / 8 THR A  46
LEU A 103
LEU A 101
VAL A  33
 None
 0.86A 4c9nA-1vp5A:
undetectable		 4c9nA-1vp5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		5 / 11 THR A 214
ALA A 216
PHE A 191
VAL A   3
TYR A  41
 None
NAP  A 300 (-3.1A)
NAP  A 300 (-4.5A)
None
None
 1.26A 4claA-1vp5A:
undetectable		 4claA-1vp5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		4 / 5 GLY A 194
ARG A 195
GLU A 193
PHE A 269
 None
None
NAP  A 300 (-3.4A)
None
 1.22A 4r82A-1vp5A:
undetectable
4r82B-1vp5A:
undetectable		 4r82A-1vp5A:
21.60
4r82B-1vp5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		5 / 12 PHE A  22
LEU A 284
GLN A 113
ALA A  47
SER A  49
 NAP  A 300 (-4.5A)
None
NAP  A 300 ( 4.3A)
None
None
 1.06A 4wnwB-1vp5A:
undetectable		 4wnwB-1vp5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		4 / 5 THR A  46
ALA A  47
THR A  78
TYR A 109
 None
 1.02A 5ecmA-1vp5A:
undetectable		 5ecmA-1vp5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		4 / 6 THR A  46
ALA A  47
THR A  78
TYR A 109
 None
 0.96A 5ecoA-1vp5A:
2.0		 5ecoA-1vp5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		5 / 12 THR A  46
ALA A  47
ILE A 231
GLY A  20
LEU A 110
 None
None
NAP  A 300 (-4.7A)
NAP  A 300 (-3.4A)
None
 0.82A 5nfjA-1vp5A:
2.3		 5nfjA-1vp5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 251
SER A 206
ILE A 207
VAL A 203
THR A 261
 None
 1.24A 6debB-1vp5A:
undetectable		 6debB-1vp5A:
14.34