SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vpa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A 109
GLY A 195
ASP A 196
 None
 0.56A 1kf6A-1vpaA:
undetectable
1kf6B-1vpaA:
undetectable		 1kf6A-1vpaA:
17.59
1kf6B-1vpaA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 LEU A  36
PRO A  35
LEU A   6
ILE A  50
 None
 0.82A 2qd4A-1vpaA:
3.0		 2qd4A-1vpaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 8 ALA A  86
VAL A   3
GLY A  71
ILE A  72
ILE A   5
 None
 1.19A 3ekpA-1vpaA:
undetectable		 3ekpA-1vpaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLN A 159
HIS A 170
ARG A  79
ASP A 178
 None
 1.20A 3nvcA-1vpaA:
undetectable		 3nvcA-1vpaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 LEU A  70
GLY A  71
PHE A  89
PHE A  93
 None
 1.14A 3smtA-1vpaA:
undetectable		 3smtA-1vpaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 THR A  38
PHE A  39
SER A  42
LEU A 128
ALA A 160
 None
 1.40A 3u9fG-1vpaA:
0.0
3u9fH-1vpaA:
0.0		 3u9fG-1vpaA:
19.28
3u9fH-1vpaA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 LEU A  36
PRO A  35
LEU A   6
ILE A  50
 None
 0.91A 4f4dB-1vpaA:
3.3		 4f4dB-1vpaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 THR A  78
GLU A 175
HIS A 170
 None
 0.84A 5xioA-1vpaA:
3.7		 5xioA-1vpaA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A  99
VAL A 113
PRO A 158
THR A 157
THR A 203
 None
None
None
None
CTP  A 500 ( 4.6A)
 1.29A 5xipC-1vpaA:
2.7		 5xipC-1vpaA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A  99
VAL A 113
PRO A 158
THR A 157
THR A 203
 None
None
None
None
CTP  A 500 ( 4.6A)
 1.28A 5xipD-1vpaA:
3.5		 5xipD-1vpaA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 THR A  78
GLU A 175
HIS A 170
 None
 0.79A 5xiqB-1vpaA:
3.0		 5xiqB-1vpaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 THR A  78
GLU A 175
HIS A 170
 None
 0.84A 5xiqD-1vpaA:
2.9		 5xiqD-1vpaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A 105
ARG A  14
ARG A  79
 None
ACY  A 700 ( 3.1A)
None
 0.82A 6bplA-1vpaA:
undetectable
6bplB-1vpaA:
undetectable		 6bplA-1vpaA:
15.04
6bplB-1vpaA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 THR A 203
THR A 157
HIS A 101
GLY A  10
 CTP  A 500 ( 4.6A)
None
None
CTP  A 500 (-3.2A)
 1.20A 6gbnC-1vpaA:
2.3		 6gbnC-1vpaA:
20.09