SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vpb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 379
PHE A 365
PHE A 436
LEU A 407
 None
 1.21A 1ea1A-1vpbA:
undetectable		 1ea1A-1vpbA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 340
ASP A 284
GLY A 336
ILE A 309
ARG A 307
 None
 1.33A 1tmxA-1vpbA:
undetectable		 1tmxA-1vpbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		4 / 7 PRO A 241
SER A 244
ILE A 426
GLY A 415
 None
 0.91A 2y7kA-1vpbA:
undetectable		 2y7kA-1vpbA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		5 / 9 VAL A 150
GLY A 151
LEU A 218
ILE A 213
ALA A 140
 None
 0.95A 2z0yA-1vpbA:
undetectable		 2z0yA-1vpbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 106
ARG A 105
ILE A 165
ASN A 167
 None
 1.02A 2zseA-1vpbA:
undetectable		 2zseA-1vpbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ALA A 140
ILE A 147
LEU A 218
ALA A 182
 None
 0.75A 3r9sA-1vpbA:
undetectable		 3r9sA-1vpbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ALA A 140
ILE A 147
LEU A 218
ALA A 182
 None
 0.76A 3r9sC-1vpbA:
undetectable		 3r9sC-1vpbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ALA A 140
ILE A 147
LEU A 218
ALA A 182
 None
 0.75A 3r9tA-1vpbA:
undetectable		 3r9tA-1vpbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 245
ASP A 417
ASP A 346
 None
 0.87A 3uj7A-1vpbA:
undetectable		 3uj7A-1vpbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 247
GLY A 380
TYR A 379
SER A 378
 None
 0.92A 4cp3A-1vpbA:
undetectable
4cp3B-1vpbA:
undetectable		 4cp3A-1vpbA:
13.56
4cp3B-1vpbA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 428
ALA A 413
VAL A 412
 None
 0.64A 4o2bC-1vpbA:
undetectable		 4o2bC-1vpbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 267
PHE A 310
LEU A 248
MET A 342
 None
 0.98A 5mzjA-1vpbA:
undetectable		 5mzjA-1vpbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		4 / 6 VAL A 400
LEU A 349
MET A 342
ARG A 419
 None
 0.91A 6brdB-1vpbA:
undetectable		 6brdB-1vpbA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1vpb PUTATIVE MODULATOR
OF DNA GYRASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 309
ASN A 272
GLY A 313
ALA A 276
LEU A 267
 None
 1.03A 6dwnD-1vpbA:
undetectable		 6dwnD-1vpbA:
10.74