SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vpe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 10 ALA A 329
PHE A 323
GLY A 331
GLU A 324
PRO A 274
 None
None
None
ANP  A 400 (-3.0A)
None
 1.36A 1cmcA-1vpeA:
undetectable
1cmcB-1vpeA:
undetectable		 1cmcA-1vpeA:
17.55
1cmcB-1vpeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 5 LYS A 197
ALA A 196
ASP A 355
GLY A 318
 ANP  A 400 (-3.6A)
ANP  A 400 (-3.1A)
ANP  A 400 (-4.2A)
ANP  A 400 ( 3.8A)
 1.06A 1e7cA-1vpeA:
undetectable		 1e7cA-1vpeA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 7 VAL A 264
LEU A 303
PHE A 304
LEU A 308
ALA A 338
 None
 1.30A 1j8uA-1vpeA:
undetectable		 1j8uA-1vpeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 ALA A 145
PHE A  22
ILE A  44
LEU A  80
THR A 148
 None
None
None
None
3PG  A 401 ( 4.4A)
 1.01A 1jolA-1vpeA:
undetectable		 1jolA-1vpeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 LEU A  80
ARG A  38
VAL A  24
ALA A  40
ALA A  39
 None
 1.05A 1n5xA-1vpeA:
undetectable		 1n5xA-1vpeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 LEU A 113
LEU A  80
VAL A  24
ALA A  40
ALA A  39
 None
 1.15A 1n5xA-1vpeA:
undetectable		 1n5xA-1vpeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 LEU A  80
ARG A  38
VAL A  24
ALA A  40
ALA A  39
 None
 1.05A 1n5xB-1vpeA:
undetectable		 1n5xB-1vpeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 LEU A 113
LEU A  80
VAL A  24
ALA A  40
ALA A  39
 None
 1.15A 1n5xB-1vpeA:
undetectable		 1n5xB-1vpeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 8 THR A 313
LEU A 178
VAL A 181
VAL A 191
 None
 0.81A 1t86A-1vpeA:
undetectable		 1t86A-1vpeA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 8 GLY A 354
GLY A 353
GLY A 352
SER A 356
LEU A 380
 ANP  A 400 (-3.6A)
ANP  A 400 (-3.0A)
None
ANP  A 400 (-2.4A)
None
 1.01A 1yajC-1vpeA:
undetectable		 1yajC-1vpeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 8 GLY A 375
GLY A 376
GLY A 377
SER A 379
ALA A 378
 None
ANP  A 400 (-3.5A)
ANP  A 400 ( 4.5A)
None
None
 1.06A 1yajC-1vpeA:
undetectable		 1yajC-1vpeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 7 THR A 313
LEU A 178
VAL A 181
VAL A 191
 None
 0.78A 2cppA-1vpeA:
0.0		 2cppA-1vpeA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 THR A 332
ALA A 340
THR A 349
VAL A 351
GLY A 352
 None
 1.03A 2ve3B-1vpeA:
undetectable		 2ve3B-1vpeA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_A_TESA339_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 10 ILE A 296
ASN A 317
TRP A 316
VAL A 315
VAL A 314
 None
ANP  A 400 (-3.1A)
None
None
None
 1.35A 3burA-1vpeA:
undetectable		 3burA-1vpeA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_B_TESB340_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 10 ILE A 296
ASN A 317
TRP A 316
VAL A 315
VAL A 314
 None
ANP  A 400 (-3.1A)
None
None
None
 1.28A 3burB-1vpeA:
undetectable		 3burB-1vpeA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 GLY A 353
VAL A  20
GLY A 147
ALA A  39
ALA A  40
 ANP  A 400 (-3.0A)
None
3PG  A 401 (-4.7A)
None
None
 1.06A 3keeC-1vpeA:
undetectable		 3keeC-1vpeA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 GLY A 354
VAL A  20
GLY A 147
ALA A  39
ALA A  40
 ANP  A 400 (-3.6A)
None
3PG  A 401 (-4.7A)
None
None
 1.07A 3keeC-1vpeA:
undetectable		 3keeC-1vpeA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 8 GLY A 194
PHE A 382
PHE A 146
GLY A 353
 None
None
None
ANP  A 400 (-3.0A)
 0.86A 3ko0O-1vpeA:
undetectable
3ko0Q-1vpeA:
undetectable		 3ko0O-1vpeA:
15.11
3ko0Q-1vpeA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 GLY A 194
VAL A 192
VAL A 191
ALA A 220
ILE A 296
 None
None
None
ANP  A 400 (-3.7A)
None
 0.99A 3ku1H-1vpeA:
2.9		 3ku1H-1vpeA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 159
SER A 155
GLU A 123
SER A  58
THR A 117
 None
 1.49A 3r75B-1vpeA:
2.4		 3r75B-1vpeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 5 LEU A 388
ALA A 392
MET A 171
ASN A 143
 None
 1.36A 3uq6A-1vpeA:
5.8		 3uq6A-1vpeA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 9 GLY A 353
GLY A 354
ASN A 361
SER A 379
GLY A 376
 ANP  A 400 (-3.0A)
ANP  A 400 (-3.6A)
None
None
ANP  A 400 (-3.5A)
 1.25A 3ztvA-1vpeA:
undetectable		 3ztvA-1vpeA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		3 / 3 LEU A  60
GLU A 115
SER A  58
 None
 0.70A 4ccqA-1vpeA:
2.1		 4ccqA-1vpeA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 ALA A 145
PHE A  22
ILE A  44
LEU A  80
THR A 148
 None
None
None
None
3PG  A 401 ( 4.4A)
 1.01A 4fhbA-1vpeA:
undetectable		 4fhbA-1vpeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 8 THR A 313
LEU A 178
VAL A 181
VAL A 191
 None
 0.76A 4l4aA-1vpeA:
undetectable		 4l4aA-1vpeA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 8 THR A 313
LEU A 178
VAL A 181
VAL A 191
 None
 0.77A 4l4dA-1vpeA:
0.0		 4l4dA-1vpeA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 8 THR A 313
LEU A 178
VAL A 181
VAL A 191
 None
 0.81A 4l4eA-1vpeA:
0.0		 4l4eA-1vpeA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 8 THR A 313
LEU A 178
VAL A 181
VAL A 191
 None
 0.79A 4l4fA-1vpeA:
0.0		 4l4fA-1vpeA:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		8 / 12 GLY A 195
ALA A 196
GLY A 219
PHE A 223
MET A 292
LEU A 294
GLY A 321
VAL A 322
 ANP  A 400 (-3.5A)
ANP  A 400 (-3.1A)
ANP  A 400 (-3.3A)
None
None
None
ANP  A 400 (-3.1A)
ANP  A 400 (-3.0A)
 0.42A 4o33A-1vpeA:
51.6		 4o33A-1vpeA:
48.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		8 / 12 GLY A 195
ALA A 196
GLY A 219
PHE A 223
MET A 292
LEU A 294
GLY A 321
VAL A 322
 ANP  A 400 (-3.5A)
ANP  A 400 (-3.1A)
ANP  A 400 (-3.3A)
None
None
None
ANP  A 400 (-3.1A)
ANP  A 400 (-3.0A)
 0.43A 4o3fA-1vpeA:
49.3		 4o3fA-1vpeA:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 ALA A 145
PHE A  22
ILE A  44
LEU A  80
THR A 148
 None
None
None
None
3PG  A 401 ( 4.4A)
 0.92A 4pstA-1vpeA:
undetectable		 4pstA-1vpeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 ALA A 145
PHE A  22
ILE A  44
LEU A  80
THR A 148
 None
None
None
None
3PG  A 401 ( 4.4A)
 0.95A 4psyA-1vpeA:
undetectable		 4psyA-1vpeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 6 LEU A  80
LEU A 112
VAL A 111
PHE A  90
 None
 1.10A 4uswA-1vpeA:
undetectable		 4uswA-1vpeA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 6 GLU A 366
GLY A 147
ASP A  21
GLY A 376
 None
3PG  A 401 (-4.7A)
3PG  A 401 (-2.9A)
ANP  A 400 (-3.5A)
 0.75A 5cdnA-1vpeA:
undetectable
5cdnB-1vpeA:
undetectable		 5cdnA-1vpeA:
23.51
5cdnB-1vpeA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 6 GLU A 366
GLY A 147
ASP A  21
GLY A 376
 None
3PG  A 401 (-4.7A)
3PG  A 401 (-2.9A)
ANP  A 400 (-3.5A)
 0.77A 5cdnR-1vpeA:
undetectable
5cdnS-1vpeA:
undetectable		 5cdnR-1vpeA:
23.51
5cdnS-1vpeA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 6 GLU A 366
GLY A 147
ASP A  21
GLY A 376
 None
3PG  A 401 (-4.7A)
3PG  A 401 (-2.9A)
ANP  A 400 (-3.5A)
 0.80A 5cdnC-1vpeA:
undetectable
5cdnD-1vpeA:
undetectable		 5cdnC-1vpeA:
23.51
5cdnD-1vpeA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 6 GLU A 366
GLY A 147
ASP A  21
GLY A 376
 None
3PG  A 401 (-4.7A)
3PG  A 401 (-2.9A)
ANP  A 400 (-3.5A)
 0.78A 5cdnT-1vpeA:
undetectable
5cdnU-1vpeA:
undetectable		 5cdnT-1vpeA:
23.51
5cdnU-1vpeA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 9 ARG A 151
ALA A 152
LEU A 388
GLY A 390
GLU A 381
 3PG  A 401 (-3.8A)
None
None
None
None
 1.08A 5dqfA-1vpeA:
undetectable		 5dqfA-1vpeA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 11 VAL A  99
VAL A 103
ILE A 159
ILE A  17
LEU A 114
 None
 0.98A 5e4dB-1vpeA:
undetectable		 5e4dB-1vpeA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 ALA A 145
PHE A  22
ILE A  44
LEU A  80
THR A 148
 None
None
None
None
3PG  A 401 ( 4.4A)
 1.06A 5e8qB-1vpeA:
undetectable		 5e8qB-1vpeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 ALA A 145
PHE A  22
ILE A  44
LEU A  80
THR A 148
 None
None
None
None
3PG  A 401 ( 4.4A)
 1.06A 5eajB-1vpeA:
undetectable		 5eajB-1vpeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 GLY A 293
GLY A 331
GLY A 321
THR A 332
ILE A 301
 None
None
ANP  A 400 (-3.1A)
None
None
 0.99A 5ehiA-1vpeA:
undetectable		 5ehiA-1vpeA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 6 GLY A 375
THR A 374
SER A 379
HIS A 371
 None
 1.06A 5ewuB-1vpeA:
undetectable		 5ewuB-1vpeA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 LYS A 333
VAL A 335
ILE A 339
ALA A 340
ILE A 296
 None
 0.82A 5j2tC-1vpeA:
undetectable		 5j2tC-1vpeA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 LYS A 333
VAL A 335
ILE A 339
ALA A 340
VAL A 192
 None
 0.66A 5j2tC-1vpeA:
undetectable		 5j2tC-1vpeA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		3 / 3 LYS A 101
ASP A  97
ILE A  55
 None
 0.86A 5kc4E-1vpeA:
undetectable		 5kc4E-1vpeA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A  17
LEU A  60
VAL A  76
LEU A  80
ILE A  44
 None
 0.93A 5mugA-1vpeA:
undetectable		 5mugA-1vpeA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		4 / 8 LEU A 114
ALA A 135
VAL A  91
HIS A 141
 None
 1.03A 5nu7A-1vpeA:
undetectable		 5nu7A-1vpeA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 ALA A 145
PHE A  22
ILE A  44
LEU A  80
THR A 148
 None
None
None
None
3PG  A 401 ( 4.4A)
 1.05A 5ujxB-1vpeA:
undetectable		 5ujxB-1vpeA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 ALA A 145
PHE A  22
ILE A  44
LEU A  80
THR A 148
 None
None
None
None
3PG  A 401 ( 4.4A)
 0.91A 5z6jA-1vpeA:
undetectable		 5z6jA-1vpeA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 ALA A 145
PHE A  22
ILE A  44
LEU A  80
THR A 148
 None
None
None
None
3PG  A 401 ( 4.4A)
 0.90A 5z6kA-1vpeA:
undetectable		 5z6kA-1vpeA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 1vpe PHOSPHOGLYCERATE
KINASE
(Thermotoga
maritima) 		5 / 12 LEU A 178
LEU A 383
GLY A 352
TYR A 189
PRO A 185
 None
 1.12A 6ce2B-1vpeA:
undetectable		 6ce2B-1vpeA:
15.15