SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 6 LEU A 134
LEU A 161
TRP A 159
PHE A 191
 None
 1.42A 1ru9H-1vpkA:
undetectable
1ru9L-1vpkA:
undetectable		 1ru9H-1vpkA:
18.65
1ru9L-1vpkA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 6 LEU A 134
LEU A 161
TRP A 159
PHE A 191
 None
 1.40A 1rukH-1vpkA:
undetectable
1rukL-1vpkA:
undetectable		 1rukH-1vpkA:
18.65
1rukL-1vpkA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 8 THR A 131
LEU A 205
VAL A 201
THR A 231
 None
 1.17A 1uyuA-1vpkA:
undetectable		 1uyuA-1vpkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 8 THR A 131
LEU A 205
VAL A 201
THR A 231
 None
 1.08A 1uyuB-1vpkA:
0.0		 1uyuB-1vpkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		5 / 11 PHE A  35
PHE A  42
ILE A  14
ILE A  98
LEU A  89
 None
 0.98A 1z11A-1vpkA:
undetectable		 1z11A-1vpkA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 8 LEU A 166
VAL A 157
LEU A 193
VAL A 222
 None
 0.86A 2bdmA-1vpkA:
undetectable		 2bdmA-1vpkA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA A  66
LEU A  91
PHE A  42
ILE A  98
LEU A  10
 None
 1.15A 2oipD-1vpkA:
undetectable		 2oipD-1vpkA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		5 / 11 LEU A 166
PHE A 127
LEU A 134
VAL A 204
VAL A 222
 None
 1.23A 2po5B-1vpkA:
undetectable		 2po5B-1vpkA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 8 PHE A  68
VAL A  70
MET A  78
ILE A  75
 None
 1.08A 4a97D-1vpkA:
undetectable		 4a97D-1vpkA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 8 PHE A  68
VAL A  70
MET A  78
ILE A  75
 None
 1.04A 4a97G-1vpkA:
undetectable		 4a97G-1vpkA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 8 PHE A  68
VAL A  70
MET A  78
ILE A  75
 None
 1.06A 4a97I-1vpkA:
undetectable		 4a97I-1vpkA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA A  55
PHE A  33
ALA A  46
VAL A  53
ASP A  12
 None
 1.29A 4df3A-1vpkA:
undetectable		 4df3A-1vpkA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA A  55
PHE A  33
ALA A  46
VAL A  53
ASP A  12
 None
 1.29A 4df3B-1vpkA:
undetectable		 4df3B-1vpkA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 8 GLU A 117
ILE A  62
VAL A   3
PHE A  42
 None
 0.96A 4dx7B-1vpkA:
undetectable		 4dx7B-1vpkA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		3 / 3 PRO A 248
ILE A 353
SER A 344
 None
 0.65A 5fsaA-1vpkA:
undetectable		 5fsaA-1vpkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		3 / 3 LYS A  54
LEU A  21
ILE A  14
 None
 0.75A 5kc4A-1vpkA:
undetectable		 5kc4A-1vpkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 4 GLU A 336
PRO A 350
ILE A 353
LEU A 351
 None
 1.11A 5m45A-1vpkA:
0.0		 5m45A-1vpkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 4 GLU A 336
PRO A 350
ILE A 353
LEU A 351
 None
 1.07A 5m45D-1vpkA:
0.0		 5m45D-1vpkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 4 GLU A 336
PRO A 350
ILE A 353
LEU A 351
 None
 1.10A 5m45G-1vpkA:
0.0		 5m45G-1vpkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		4 / 4 GLU A 336
PRO A 350
ILE A 353
LEU A 351
 None
 1.08A 5m45J-1vpkA:
undetectable		 5m45J-1vpkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		3 / 3 LEU A 178
LEU A 168
TRP A 159
 None
 0.94A 5nwuA-1vpkA:
undetectable		 5nwuA-1vpkA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 1vpk DNA POLYMERASE III,
BETA SUBUNIT
(Thermotoga
maritima) 		5 / 12 MET A 289
VAL A 307
ILE A 284
GLU A 336
THR A 253
 None
 1.43A 5w8aA-1vpkA:
0.0		 5w8aA-1vpkA:
19.28