SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 7 GLY A  39
THR A  44
ILE A  18
GLY A  41
 SO4  A 245 (-3.5A)
None
None
SO4  A 245 (-3.3A)
 0.83A 1usqF-1vplA:
undetectable		 1usqF-1vplA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 11 VAL A 173
ILE A 176
LEU A 177
LEU A  81
LEU A 158
 None
 1.30A 2a15A-1vplA:
undetectable		 2a15A-1vplA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 5 THR A  43
ASP A 159
PRO A  82
SER A  50
 SO4  A 245 (-3.9A)
None
None
None
 1.39A 2hdnA-1vplA:
undetectable
2hdnB-1vplA:
0.0
2hdnD-1vplA:
undetectable		 2hdnA-1vplA:
12.57
2hdnB-1vplA:
22.70
2hdnD-1vplA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 5 SER A  50
THR A  43
ASP A 159
PRO A  82
 None
SO4  A 245 (-3.9A)
None
None
 1.37A 2hdnB-1vplA:
0.0
2hdnC-1vplA:
0.0
2hdnD-1vplA:
undetectable		 2hdnB-1vplA:
22.70
2hdnC-1vplA:
12.57
2hdnD-1vplA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A 143
LEU A 144
ALA A 118
ALA A 101
 None
 0.80A 2vcvF-1vplA:
undetectable		 2vcvF-1vplA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A 143
LEU A 144
ALA A 118
ALA A 101
 None
 0.81A 2vcvP-1vplA:
undetectable		 2vcvP-1vplA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A  96
VAL A 132
TYR A 135
ILE A 128
 None
 1.23A 2x45B-1vplA:
undetectable		 2x45B-1vplA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A  96
VAL A 132
TYR A 135
ILE A 128
 None
 1.21A 2x45C-1vplA:
undetectable		 2x45C-1vplA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 9 THR A 186
VAL A  74
ARG A  75
ILE A  26
GLY A   2
 None
 1.25A 3cv9A-1vplA:
undetectable		 3cv9A-1vplA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 4 LEU A 124
GLY A 125
GLY A 123
THR A 119
 None
 0.92A 3si7A-1vplA:
20.5		 3si7A-1vplA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		3 / 3 GLY A  39
GLY A  41
THR A  43
 SO4  A 245 (-3.5A)
SO4  A 245 (-3.3A)
SO4  A 245 (-3.9A)
 0.44A 3si7B-1vplA:
17.3		 3si7B-1vplA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 7 ILE A 212
THR A 215
PHE A  32
ASP A 159
 None
 1.17A 4iarA-1vplA:
undetectable		 4iarA-1vplA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 9 PRO A  37
GLY A 210
ILE A  35
MET A 194
LEU A 206
 None
 1.21A 4x3mB-1vplA:
undetectable		 4x3mB-1vplA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 9 ASN A 169
ALA A 170
VAL A 173
ARG A 174
GLU A  84
 None
 0.86A 5dbyA-1vplA:
undetectable		 5dbyA-1vplA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 5 ALA A 146
PRO A 161
GLY A  41
LEU A 188
 None
None
SO4  A 245 (-3.3A)
None
 1.02A 5eslA-1vplA:
undetectable		 5eslA-1vplA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A  94
LEU A 124
GLY A 125
THR A 134
MET A 139
 None
 1.16A 5x5qB-1vplA:
undetectable		 5x5qB-1vplA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		3 / 3 LYS A 142
ASN A 169
SER A 136
 None
 1.25A 5yw0A-1vplA:
undetectable		 5yw0A-1vplA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 12 ARG A 224
LYS A 222
VAL A 233
ILE A 230
ILE A 204
 None
 1.18A 6gsdA-1vplA:
undetectable		 6gsdA-1vplA:
15.69