SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vpq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 1vpq HYPOTHETICAL PROTEIN
TM1631
(Thermotoga
maritima) 		4 / 8 GLY A  75
THR A  73
MET A  92
LEU A 132
 None
 0.87A 1aegA-1vpqA:
undetectable		 1aegA-1vpqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 1vpq HYPOTHETICAL PROTEIN
TM1631
(Thermotoga
maritima) 		4 / 4 LEU A 173
PRO A 174
LEU A 176
ARG A 207
 None
None
None
SO4  A 263 (-2.8A)
 1.49A 2qd2A-1vpqA:
undetectable		 2qd2A-1vpqA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1vpq HYPOTHETICAL PROTEIN
TM1631
(Thermotoga
maritima) 		4 / 8 LEU A 251
VAL A  18
GLY A 244
GLN A 245
 None
 0.72A 2wd9B-1vpqA:
undetectable		 2wd9B-1vpqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1vpq HYPOTHETICAL PROTEIN
TM1631
(Thermotoga
maritima) 		4 / 7 TYR A 136
TYR A 138
GLU A 100
TRP A  53
 None
 1.28A 3cotA-1vpqA:
7.1		 3cotA-1vpqA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 1vpq HYPOTHETICAL PROTEIN
TM1631
(Thermotoga
maritima) 		4 / 5 PHE A 190
ASP A 169
PHE A 192
VAL A 224
 None
 0.95A 5a1rA-1vpqA:
undetectable		 5a1rA-1vpqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1vpq HYPOTHETICAL PROTEIN
TM1631
(Thermotoga
maritima) 		3 / 3 THR A 234
MET A   1
HIS A   0
 None
 1.01A 5uunA-1vpqA:
undetectable		 5uunA-1vpqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1vpq HYPOTHETICAL PROTEIN
TM1631
(Thermotoga
maritima) 		4 / 7 TRP A 199
HIS A 193
ASP A 169
GLU A 216
 SO4  A 263 ( 4.9A)
SO4  A 262 (-3.9A)
None
None
 1.42A 6mn4F-1vpqA:
undetectable		 6mn4F-1vpqA:
21.16