SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		5 / 11 ALA A1189
LEU A1003
LEU A1008
LEU A 983
SER A1134
 None
 0.97A 1h9zA-1vprA:
undetectable		 1h9zA-1vprA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		5 / 11 ALA A1189
LEU A1003
LEU A1008
LEU A 983
SER A1134
 None
 0.96A 1ha2A-1vprA:
undetectable		 1ha2A-1vprA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 6 LEU A 882
GLU A 872
THR A1096
TYR A1071
 None
 1.32A 1qvuA-1vprA:
undetectable		 1qvuA-1vprA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		3 / 3 ARG A1124
ARG A1143
ILE A1163
 None
 0.80A 1uobA-1vprA:
undetectable		 1uobA-1vprA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 7 PHE A1129
GLU A1105
TYR A1168
TRP A1117
 None
 1.46A 2aowA-1vprA:
undetectable		 2aowA-1vprA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 8 ALA A1038
GLN A1037
LEU A 927
SER A1086
 None
 1.03A 3qj7A-1vprA:
undetectable
3qj7D-1vprA:
undetectable		 3qj7A-1vprA:
21.00
3qj7D-1vprA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		3 / 3 ASP A1186
GLY A1100
TYR A1102
 None
 0.76A 3w9tC-1vprA:
undetectable		 3w9tC-1vprA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		3 / 3 ASP A1186
GLY A1100
TYR A1102
 None
 0.77A 3w9tG-1vprA:
undetectable		 3w9tG-1vprA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 7 PHE A1128
TYR A1102
PRO A1007
TRP A1130
 None
 1.47A 4grqA-1vprA:
0.0
4grqC-1vprA:
0.0		 4grqA-1vprA:
15.78
4grqC-1vprA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		3 / 3 GLU A1133
LYS A 992
ASN A1112
 None
 1.07A 4y1dA-1vprA:
undetectable
4y1dD-1vprA:
undetectable		 4y1dA-1vprA:
18.16
4y1dD-1vprA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 5 VAL A 954
VAL A1147
GLY A1148
PHE A1152
 None
 1.07A 5d4nA-1vprA:
undetectable
5d4nC-1vprA:
undetectable		 5d4nA-1vprA:
16.22
5d4nC-1vprA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 7 ALA A 937
GLY A 879
ARG A1073
GLY A 934
 None
 0.89A 5e26A-1vprA:
undetectable
5e26B-1vprA:
undetectable		 5e26A-1vprA:
22.38
5e26B-1vprA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 7 GLY A 879
ARG A1073
GLY A 934
ALA A 937
 None
 0.85A 5e26C-1vprA:
undetectable
5e26D-1vprA:
undetectable		 5e26C-1vprA:
22.38
5e26D-1vprA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		3 / 3 HIS A1065
GLU A1105
TRP A1117
 None
 1.13A 5odiD-1vprA:
undetectable		 5odiD-1vprA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		3 / 3 HIS A1065
GLU A1105
TRP A1117
 None
 1.21A 5odrD-1vprA:
undetectable		 5odrD-1vprA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 7 LYS A1089
GLY A1068
MET A1153
TYR A1168
 None
 1.38A 6ag0A-1vprA:
undetectable		 6ag0A-1vprA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 7 LYS A1089
GLY A1068
MET A1153
TYR A1168
 None
 1.41A 6ag0C-1vprA:
undetectable		 6ag0C-1vprA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 8 THR A1188
CYH A 991
TYR A 996
LEU A1008
 None
 1.45A 6cnjD-1vprA:
undetectable
6cnjE-1vprA:
undetectable		 6cnjD-1vprA:
12.04
6cnjE-1vprA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 8 TRP A1010
THR A1198
CYH A1137
LEU A1014
 None
 1.47A 6cnjD-1vprA:
undetectable
6cnjE-1vprA:
undetectable		 6cnjD-1vprA:
12.04
6cnjE-1vprA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1vpr LUCIFERASE
(Lingulodinium
polyedra) 		4 / 8 TYR A1102
TRP A1010
THR A1198
LEU A1014
 None
 1.48A 6cnjD-1vprA:
undetectable
6cnjE-1vprA:
undetectable		 6cnjD-1vprA:
12.04
6cnjE-1vprA:
11.35