SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vpv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 8 LEU A 250
TYR A 254
ILE A 281
ILE A 217
ILE A 161
 None
 1.08A 2bu8A-1vpvA:
undetectable		 2bu8A-1vpvA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 7 SER A 122
LEU A 246
PHE A 162
THR A 276
 PLM  A 501 (-3.7A)
None
PLM  A 501 (-3.7A)
None
 0.97A 2f78A-1vpvA:
undetectable		 2f78A-1vpvA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 8 ILE A 268
PHE A 162
VAL A 176
LEU A 170
 PLM  A 501 ( 4.5A)
PLM  A 501 (-3.7A)
None
None
 0.90A 2w98B-1vpvA:
undetectable		 2w98B-1vpvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		3 / 3 GLY A 227
TYR A 254
SER A 228
 None
 0.73A 2xatA-1vpvA:
undetectable		 2xatA-1vpvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 ILE A 281
GLY A 234
GLY A 123
ASP A  12
LEU A 247
 None
None
PLM  A 501 (-4.0A)
None
None
 1.22A 2zw9A-1vpvA:
2.1		 2zw9A-1vpvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 LEU A 250
PHE A 279
LEU A 230
ILE A 213
SER A 228
 None
 1.28A 3aqiB-1vpvA:
2.0		 3aqiB-1vpvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 11 ILE A 281
ALA A 124
ILE A 261
LEU A 247
VAL A 232
 None
PLM  A 501 (-4.4A)
None
None
None
 1.13A 3n0hA-1vpvA:
undetectable		 3n0hA-1vpvA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 ILE A 281
ALA A 124
ILE A 261
LEU A 247
VAL A 232
 None
PLM  A 501 (-4.4A)
None
None
None
 1.11A 3s3vA-1vpvA:
undetectable		 3s3vA-1vpvA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 LEU A 250
PHE A 279
LEU A 230
ILE A 213
SER A 228
 None
 1.25A 3w1wA-1vpvA:
2.6		 3w1wA-1vpvA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 LEU A 247
LEU A 246
LEU A 216
ILE A 281
TYR A 203
 None
 1.14A 4a7aB-1vpvA:
undetectable		 4a7aB-1vpvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 ILE A 125
VAL A 272
ASP A  12
ILE A 268
ARG A  42
 None
None
None
PLM  A 501 ( 4.5A)
None
 1.15A 4i41A-1vpvA:
undetectable		 4i41A-1vpvA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 11 GLY A 280
SER A 122
ILE A 268
LEU A 193
ILE A 161
 PLM  A 501 (-3.8A)
PLM  A 501 (-3.7A)
PLM  A 501 ( 4.5A)
None
None
 1.17A 4xumB-1vpvA:
undetectable		 4xumB-1vpvA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 4 LEU A 170
ILE A 268
HIS A 271
VAL A 272
 None
PLM  A 501 ( 4.5A)
PLM  A 501 (-3.6A)
None
 0.93A 4xyzA-1vpvA:
undetectable		 4xyzA-1vpvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 7 VAL A 164
THR A 276
LEU A 200
MET A 264
 None
 1.02A 5e4dA-1vpvA:
undetectable
5e4dB-1vpvA:
undetectable		 5e4dA-1vpvA:
22.55
5e4dB-1vpvA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 9 VAL A   3
ILE A 142
VAL A 145
LEU A 149
ARG A 133
 None
 1.05A 5fxfA-1vpvA:
2.3		 5fxfA-1vpvA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 10 VAL A   3
ILE A 142
VAL A 145
LEU A 149
ARG A 133
 None
 1.05A 5fxfB-1vpvA:
0.8		 5fxfB-1vpvA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 5 TYR A  75
SER A 101
ALA A 102
THR A  90
 None
 1.19A 5n0tA-1vpvA:
undetectable		 5n0tA-1vpvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 5 PRO A 274
GLY A 275
THR A 276
ASN A 239
 None
 0.98A 5x23A-1vpvA:
undetectable		 5x23A-1vpvA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 6 PRO A 274
GLY A 275
THR A 276
ASN A 239
 None
 0.98A 5x24A-1vpvA:
undetectable		 5x24A-1vpvA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 6 PRO A 274
GLY A 275
THR A 276
ASN A 239
 None
 1.12A 5xxiA-1vpvA:
undetectable		 5xxiA-1vpvA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 LEU A 216
GLY A 234
ASP A  12
VAL A 243
LEU A 246
 None
 1.02A 6ecxA-1vpvA:
undetectable		 6ecxA-1vpvA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		4 / 8 TYR A  51
PHE A  50
VAL A 272
TYR A 169
 None
 1.02A 6huoC-1vpvA:
undetectable
6huoD-1vpvA:
undetectable		 6huoC-1vpvA:
15.05
6huoD-1vpvA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1vpv UPF0230 PROTEIN
TM1468
(Thermotoga
maritima) 		5 / 12 LEU A 220
ILE A 281
GLY A 278
PHE A 279
ALA A 121
 None
None
PLM  A 501 ( 4.5A)
None
PLM  A 501 ( 4.1A)
 1.42A 6qyaB-1vpvA:
undetectable		 6qyaB-1vpvA:
21.78