SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vqt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 LEU A 122
ASN A 123
LEU A 125
GLY A 126
LEU A 139
 None
 1.07A 1gs4A-1vqtA:
undetectable		 1gs4A-1vqtA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 6 THR A  78
LEU A  51
GLY A  76
LYS A  26
 EDO  A 204 ( 4.5A)
None
None
EDO  A 209 (-2.8A)
 1.29A 1gtiC-1vqtA:
undetectable		 1gtiC-1vqtA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.75A 1v55A-1vqtA:
0.0
1v55J-1vqtA:
undetectable		 1v55A-1vqtA:
17.18
1v55J-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 8 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.77A 1v55N-1vqtA:
undetectable
1v55W-1vqtA:
undetectable		 1v55N-1vqtA:
17.18
1v55W-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 8 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.77A 2einA-1vqtA:
undetectable
2einJ-1vqtA:
undetectable		 2einA-1vqtA:
17.18
2einJ-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 6 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.84A 2einN-1vqtA:
undetectable
2einW-1vqtA:
0.0		 2einN-1vqtA:
17.18
2einW-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLY A 133
ALA A 136
ILE A 143
ILE A 119
ILE A 147
 None
 1.04A 2hs1A-1vqtA:
undetectable		 2hs1A-1vqtA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 8 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.85A 3abkA-1vqtA:
undetectable
3abkJ-1vqtA:
undetectable		 3abkA-1vqtA:
17.18
3abkJ-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 8 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.80A 3abmN-1vqtA:
undetectable
3abmW-1vqtA:
undetectable		 3abmN-1vqtA:
17.18
3abmW-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 6 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.90A 3ag1N-1vqtA:
undetectable
3ag1W-1vqtA:
undetectable		 3ag1N-1vqtA:
17.18
3ag1W-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.85A 3ag3A-1vqtA:
undetectable
3ag3J-1vqtA:
undetectable		 3ag3A-1vqtA:
17.18
3ag3J-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 8 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.80A 3ag3N-1vqtA:
0.0
3ag3W-1vqtA:
0.0		 3ag3N-1vqtA:
17.18
3ag3W-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 8 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.83A 3asoN-1vqtA:
undetectable
3asoW-1vqtA:
undetectable		 3asoN-1vqtA:
17.18
3asoW-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 LEU A 105
PHE A  55
ILE A  49
LEU A 148
VAL A 130
 None
None
None
EDO  A 204 (-4.9A)
EDO  A 204 ( 4.9A)
 1.20A 3sp9A-1vqtA:
undetectable		 3sp9A-1vqtA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 LEU A 105
PHE A  55
ILE A  49
LEU A 148
VAL A 130
 None
None
None
EDO  A 204 (-4.9A)
EDO  A 204 ( 4.9A)
 1.16A 3sp9B-1vqtA:
undetectable		 3sp9B-1vqtA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 6 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.84A 3wg7N-1vqtA:
0.0
3wg7W-1vqtA:
0.0		 3wg7N-1vqtA:
17.18
3wg7W-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.87A 5b1bN-1vqtA:
0.0
5b1bW-1vqtA:
undetectable		 5b1bN-1vqtA:
17.18
5b1bW-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.90A 5b3sN-1vqtA:
0.0
5b3sW-1vqtA:
0.0		 5b3sN-1vqtA:
17.18
5b3sW-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 VAL A  62
ILE A  66
PHE A  77
VAL A  79
 None
 0.79A 5bmvC-1vqtA:
undetectable		 5bmvC-1vqtA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.80A 5iy5A-1vqtA:
0.0
5iy5J-1vqtA:
undetectable		 5iy5A-1vqtA:
17.18
5iy5J-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.91A 5iy5N-1vqtA:
undetectable
5iy5W-1vqtA:
undetectable		 5iy5N-1vqtA:
17.18
5iy5W-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.95A 5xdxA-1vqtA:
undetectable
5xdxJ-1vqtA:
undetectable		 5xdxA-1vqtA:
17.18
5xdxJ-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 6 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.92A 5z86N-1vqtA:
0.0
5z86W-1vqtA:
undetectable		 5z86N-1vqtA:
17.18
5z86W-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 6 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.90A 5zcoN-1vqtA:
0.0
5zcoW-1vqtA:
undetectable		 5zcoN-1vqtA:
17.18
5zcoW-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 8 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.88A 5zcpN-1vqtA:
undetectable
5zcpW-1vqtA:
undetectable		 5zcpN-1vqtA:
17.18
5zcpW-1vqtA:
16.29