SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vqu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 12 ILE A 170
ALA A 122
LEU A 302
PHE A 120
LEU A 147
 None
 1.22A 1ddrB-1vquA:
undetectable		 1ddrB-1vquA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 7 LEU A 320
ALA A 319
VAL A 337
VAL A 276
 None
 0.90A 1epbA-1vquA:
undetectable		 1epbA-1vquA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 8 LEU A 320
ALA A 319
VAL A 337
VAL A 276
 None
 0.84A 1epbB-1vquA:
undetectable		 1epbB-1vquA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 6 TRP A 178
ARG A 189
SER A 143
ASN A 294
 None
None
ACT  A 363 ( 4.3A)
None
 1.39A 1kiaC-1vquA:
2.5		 1kiaC-1vquA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 11 ILE A 239
LEU A 223
THR A 224
ILE A 271
THR A 256
 None
None
ACT  A 364 ( 4.8A)
None
None
 1.28A 1pkvA-1vquA:
undetectable
1pkvB-1vquA:
undetectable		 1pkvA-1vquA:
14.71
1pkvB-1vquA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 12 ILE A 170
ALA A 122
LEU A 302
PHE A 120
LEU A 147
 None
 1.11A 1rx3A-1vquA:
undetectable		 1rx3A-1vquA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 4 ALA A 123
VAL A 168
PHE A 120
THR A 171
 None
 1.43A 2pkkA-1vquA:
4.8		 2pkkA-1vquA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU A  54
ASN A  58
LEU A  36
LEU A 201
MET A  70
 None
 1.32A 3d90B-1vquA:
undetectable		 3d90B-1vquA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 9 GLN A 323
VAL A 328
ILE A 343
VAL A 121
VAL A 118
 None
 1.35A 3fi0H-1vquA:
undetectable		 3fi0H-1vquA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU A  57
ASN A  58
GLY A  61
MET A  70
LEU A 201
 None
 0.99A 3h52A-1vquA:
undetectable		 3h52A-1vquA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 7 MET A  37
LEU A  41
LEU A 201
TRP A  40
 None
 1.26A 3nk2X-1vquA:
undetectable		 3nk2X-1vquA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 6 GLY A 253
GLU A 245
ASP A 248
ASN A 317
 None
 1.06A 3vywC-1vquA:
undetectable		 3vywC-1vquA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 12 VAL A 301
VAL A 357
ILE A 114
LEU A 147
VAL A 152
 None
 1.04A 3w68D-1vquA:
undetectable		 3w68D-1vquA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 5 GLN A 311
THR A 307
THR A 111
LEU A 252
 None
 1.05A 4lvcB-1vquA:
2.8		 4lvcB-1vquA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		3 / 3 THR A 225
ASN A 199
PHE A 198
 None
 0.63A 4pd9A-1vquA:
undetectable		 4pd9A-1vquA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 11 ILE A 170
ALA A 122
LEU A 302
PHE A 120
LEU A 147
 None
 1.21A 4qlfA-1vquA:
undetectable		 4qlfA-1vquA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU A  57
ASN A  58
GLY A  61
MET A  70
ILE A 194
 None
 0.99A 4udcA-1vquA:
undetectable		 4udcA-1vquA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 11 SER A 110
ALA A 117
ASP A 248
GLU A 249
GLY A 105
 None
 1.43A 4zjoD-1vquA:
undetectable		 4zjoD-1vquA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 12 GLY A 251
ALA A 313
PHE A 112
ALA A 315
VAL A 118
 None
 1.13A 5n0oB-1vquA:
undetectable		 5n0oB-1vquA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 7 TYR A 125
VAL A 127
ILE A  99
ALA A 325
 None
 0.76A 5ospA-1vquA:
undetectable		 5ospA-1vquA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		3 / 3 LEU A 165
ALA A 164
LEU A 208
 None
 0.46A 5uunB-1vquA:
undetectable		 5uunB-1vquA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 10 ALA A  33
LEU A  36
MET A  70
GLU A  72
VAL A  73
 None
 1.10A 5v02B-1vquA:
undetectable
5v02R-1vquA:
undetectable		 5v02B-1vquA:
12.57
5v02R-1vquA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		5 / 12 PHE A 172
LEU A 204
PHE A 174
ALA A 238
ILE A  99
 None
 1.20A 5vc0A-1vquA:
0.0		 5vc0A-1vquA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 5 GLN A 311
THR A 307
THR A 111
LEU A 252
 None
 1.06A 6aphA-1vquA:
3.5		 6aphA-1vquA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 4 GLN A 311
THR A 307
THR A 111
LEU A 252
 None
 1.09A 6f3mA-1vquA:
undetectable		 6f3mA-1vquA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 4 GLN A 311
THR A 307
THR A 111
LEU A 252
 None
 1.08A 6f3mC-1vquA:
undetectable		 6f3mC-1vquA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Nostoc
sp.
PCC
7120) 		4 / 5 GLN A 311
THR A 307
THR A 111
LEU A 252
 None
 1.07A 6gbnB-1vquA:
undetectable		 6gbnB-1vquA:
21.24