SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 GLU A 260
TYR A 276
PHE A 262
 None
EDO  A 402 ( 3.4A)
EDO  A 408 (-4.1A)
 0.68A 1eqbB-1vqzA:
undetectable		 1eqbB-1vqzA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 GLU A 260
TYR A 276
PHE A 262
 None
EDO  A 402 ( 3.4A)
EDO  A 408 (-4.1A)
 0.68A 1eqbA-1vqzA:
undetectable		 1eqbA-1vqzA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 GLU A 260
TYR A 276
PHE A 262
 None
EDO  A 402 ( 3.4A)
EDO  A 408 (-4.1A)
 0.68A 1eqbD-1vqzA:
undetectable		 1eqbD-1vqzA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 GLU A 260
TYR A 276
PHE A 262
 None
EDO  A 402 ( 3.4A)
EDO  A 408 (-4.1A)
 0.68A 1eqbC-1vqzA:
undetectable		 1eqbC-1vqzA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 MET A 205
LEU A 201
PHE A 197
LEU A  34
ILE A 106
 None
 1.20A 1hrkA-1vqzA:
undetectable		 1hrkA-1vqzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 MET A 205
LEU A 201
PHE A 197
LEU A  34
ILE A 106
 None
 1.20A 1hrkB-1vqzA:
undetectable		 1hrkB-1vqzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 4 HIS A 146
ALA A 135
PHE A  98
GLY A 147
 EDO  A 410 (-3.8A)
EDO  A 414 (-3.9A)
None
EDO  A 409 (-3.6A)
 1.41A 1mj2D-1vqzA:
undetectable		 1mj2D-1vqzA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 270
ALA A 263
ALA A 326
LEU A 306
ILE A 323
 None
 1.04A 2h77A-1vqzA:
undetectable		 2h77A-1vqzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 270
ALA A 263
ALA A 326
LEU A 306
ILE A 323
 None
 1.01A 2h79A-1vqzA:
undetectable		 2h79A-1vqzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 MET A 205
LEU A 201
PHE A 197
LEU A  34
ILE A 106
 None
 1.21A 2hrcA-1vqzA:
undetectable		 2hrcA-1vqzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 MET A 205
LEU A 201
PHE A 197
LEU A  34
ILE A 106
 None
 1.24A 2hrcB-1vqzA:
undetectable		 2hrcB-1vqzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 MET A 205
LEU A 201
PHE A 197
LEU A  34
ILE A 106
 None
 1.18A 2pnjB-1vqzA:
undetectable		 2pnjB-1vqzA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 MET A 205
LEU A 201
PHE A 197
LEU A  34
ILE A 106
 None
 1.18A 2po5A-1vqzA:
undetectable		 2po5A-1vqzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 ILE A 143
ILE A 282
LEU A  33
 None
 0.54A 2prgA-1vqzA:
undetectable		 2prgA-1vqzA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 5 PHE A  98
PHE A 101
LEU A 201
PHE A 197
 None
 1.13A 2y69C-1vqzA:
undetectable
2y69J-1vqzA:
undetectable		 2y69C-1vqzA:
20.78
2y69J-1vqzA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 5 PHE A  98
PHE A 101
LEU A 201
PHE A 197
 None
 1.20A 3ag3C-1vqzA:
undetectable
3ag3J-1vqzA:
undetectable		 3ag3C-1vqzA:
20.78
3ag3J-1vqzA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 270
ALA A 263
ALA A 326
LEU A 306
ILE A 323
 None
 1.04A 3gwsX-1vqzA:
undetectable		 3gwsX-1vqzA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 7 ALA A 116
PHE A 131
LEU A 109
THR A 108
 None
 0.86A 4du2B-1vqzA:
0.0		 4du2B-1vqzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 GLY A  71
GLY A  44
ILE A  69
ALA A 137
ASP A 284
 None
None
None
None
EDO  A 417 (-3.0A)
 1.16A 4kicA-1vqzA:
undetectable		 4kicA-1vqzA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 GLY A  44
GLU A  52
THR A  49
 None
 0.41A 4kouA-1vqzA:
undetectable		 4kouA-1vqzA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 270
ALA A 263
ALA A 326
LEU A 306
ILE A 323
 None
 1.01A 4lnwA-1vqzA:
undetectable		 4lnwA-1vqzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 270
ALA A 263
ALA A 326
LEU A 306
ILE A 323
 None
 1.02A 4lnxA-1vqzA:
undetectable		 4lnxA-1vqzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		4 / 7 VAL A 302
ILE A 270
ILE A 273
ALA A 263
 None
 0.83A 4lv9A-1vqzA:
undetectable		 4lv9A-1vqzA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 VAL A  75
ALA A  74
VAL A  43
SER A  70
GLY A  72
 None
None
None
EDO  A 409 ( 4.5A)
None
 1.13A 4mm4B-1vqzA:
0.0		 4mm4B-1vqzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  69
GLY A  71
ARG A 142
MET A 144
ASP A 284
 None
None
None
None
EDO  A 417 (-3.0A)
 1.00A 5e72A-1vqzA:
undetectable		 5e72A-1vqzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		3 / 3 PHE A 279
ARG A  45
ALA A 287
 None
 0.96A 6ecfB-1vqzA:
undetectable		 6ecfB-1vqzA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE
(Streptococcus
pneumoniae) 		5 / 12 PHE A 262
ILE A 252
GLY A 251
ALA A 263
ASP A 167
 EDO  A 408 (-4.1A)
None
UNL  A 400 (-3.5A)
None
None
 1.02A 6iftA-1vqzA:
undetectable		 6iftA-1vqzA:
25.00