SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vr0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A  76
GLY A  69
HIS A 201
TYR A 148
LEU A 208
 None
None
3SL  A 300 (-4.6A)
3SL  A 300 (-4.8A)
None
 1.15A 1fm6X-1vr0A:
undetectable		 1fm6X-1vr0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A 109
GLY A 121
ALA A 108
LEU A 124
VAL A 223
 None
 1.10A 1i9gA-1vr0A:
undetectable		 1i9gA-1vr0A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		4 / 7 LEU A 210
ARG A  29
LEU A  74
GLY A  73
 None
3SL  A 300 (-3.7A)
None
3SL  A 300 (-3.6A)
 0.86A 1n13D-1vr0A:
undetectable
1n13E-1vr0A:
undetectable		 1n13D-1vr0A:
20.93
1n13E-1vr0A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 10 GLY A 121
VAL A 129
GLY A 126
THR A  31
VAL A  23
 None
 1.34A 1pwyE-1vr0A:
undetectable		 1pwyE-1vr0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 7 LEU A  38
ILE A 118
PRO A  47
VAL A  45
ILE A  34
 None
 1.17A 2aojB-1vr0A:
undetectable		 2aojB-1vr0A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 12 THR A  31
LEU A 119
VAL A  17
ALA A 145
VAL A 141
 None
None
None
MG  A 400 ( 4.2A)
None
 1.17A 2g72B-1vr0A:
undetectable		 2g72B-1vr0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 9 ASP A  10
GLY A 105
ILE A 109
VAL A 141
ILE A   6
 None
 1.05A 2q5kA-1vr0A:
undetectable		 2q5kA-1vr0A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 10 ILE A 133
THR A  21
VAL A 166
ILE A 163
ILE A 142
 None
 1.30A 3kpbD-1vr0A:
undetectable		 3kpbD-1vr0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		6 / 12 LEU A  38
GLY A 121
ILE A 118
PRO A  47
VAL A  45
ILE A  34
 None
 1.40A 3lzuB-1vr0A:
undetectable		 3lzuB-1vr0A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		6 / 12 LEU A  38
GLY A 121
ILE A 118
PRO A  47
VAL A  45
ILE A  34
 None
 1.41A 3tkwB-1vr0A:
undetectable		 3tkwB-1vr0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		6 / 12 LEU A  38
GLY A 121
ILE A 118
PRO A  47
VAL A  45
ILE A  34
 None
 1.48A 3tl9B-1vr0A:
undetectable		 3tl9B-1vr0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		4 / 7 VAL A 226
GLY A 121
ILE A  25
VAL A 140
 None
 0.74A 3ufnB-1vr0A:
undetectable		 3ufnB-1vr0A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 9 LEU A  67
ALA A  65
ASP A  64
VAL A  46
ILE A  99
 None
 1.42A 3wsjA-1vr0A:
undetectable		 3wsjA-1vr0A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 11 SER A 112
ALA A  22
ILE A 118
ILE A 234
ILE A 120
 None
 1.02A 4dt8A-1vr0A:
undetectable		 4dt8A-1vr0A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		4 / 8 GLU A  70
HIS A 201
ASN A 104
GLY A 146
 3SL  A 300 (-3.4A)
3SL  A 300 (-4.6A)
3SL  A 300 (-4.2A)
MG  A 400 (-4.0A)
 1.01A 4f93B-1vr0A:
undetectable		 4f93B-1vr0A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 10 ALA A 130
VAL A 226
GLY A 121
ILE A  25
VAL A 140
 None
 1.07A 4j5jB-1vr0A:
undetectable		 4j5jB-1vr0A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		3 / 3 ASP A  26
VAL A 123
ASN A  83
 MG  A 400 (-3.1A)
None
3SL  A 300 (-3.8A)
 0.80A 4lmnA-1vr0A:
undetectable		 4lmnA-1vr0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		4 / 7 LEU A 124
ASN A 125
MET A  86
ILE A 234
 None
 0.91A 4okwA-1vr0A:
undetectable		 4okwA-1vr0A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		4 / 5 VAL A 129
ILE A 133
VAL A  23
THR A  21
 None
 0.75A 4xdtA-1vr0A:
undetectable		 4xdtA-1vr0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		4 / 5 VAL A 123
TYR A 229
PRO A 227
THR A  97
 None
 1.11A 4ze1A-1vr0A:
undetectable		 4ze1A-1vr0A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		4 / 7 LEU A 119
MET A   1
VAL A 140
THR A  21
 None
 1.02A 5e4dA-1vr0A:
undetectable
5e4dB-1vr0A:
undetectable		 5e4dA-1vr0A:
21.84
5e4dB-1vr0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		3 / 3 THR A 176
ASP A 177
ALA A 178
 None
 0.00A 5g5gB-1vr0A:
undetectable		 5g5gB-1vr0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 11 ASP A   4
VAL A  24
ILE A  25
ILE A   3
ILE A 163
 None
 1.17A 5hw8D-1vr0A:
undetectable		 5hw8D-1vr0A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 9 VAL A 123
PHE A 214
VAL A 196
HIS A 201
ILE A 192
 None
None
None
3SL  A 300 (-4.6A)
None
 1.19A 5om2A-1vr0A:
undetectable
5om2B-1vr0A:
undetectable		 5om2A-1vr0A:
17.77
5om2B-1vr0A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A 234
GLY A 121
ASN A 125
ILE A 118
ALA A  22
 None
 1.28A 6qxsD-1vr0A:
undetectable		 6qxsD-1vr0A:
18.67