SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vrd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 THR A  49
ASP A 244
ASP A 334
GLY A 357
MET A 355
 None
 1.30A 1d4fC-1vrdA:
undetectable		 1d4fC-1vrdA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 ASP A 244
ASN A 273
GLY A 296
THR A 303
 None
 0.59A 1jr1B-1vrdA:
46.4		 1jr1B-1vrdA:
39.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 11 ILE A 243
THR A 245
VAL A 230
THR A 226
GLN A  75
 None
 1.43A 1tw4A-1vrdA:
undetectable		 1tw4A-1vrdA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 ILE A 243
THR A 245
VAL A 230
THR A 226
GLN A  75
 None
 1.43A 1tw4B-1vrdA:
0.0		 1tw4B-1vrdA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 ASP A 328
ILE A 444
VAL A 317
 None
 0.65A 2avvD-1vrdA:
undetectable		 2avvD-1vrdA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 VAL A 425
VAL A 429
LEU A 432
VAL A  24
 None
 0.82A 3hs6B-1vrdA:
undetectable		 3hs6B-1vrdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 ALA A 290
PRO A 330
LEU A  30
THR A  31
 None
 0.96A 4dtzA-1vrdA:
undetectable		 4dtzA-1vrdA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 VAL A 425
VAL A 429
LEU A 432
VAL A  24
 None
 0.80A 4e1gB-1vrdA:
undetectable		 4e1gB-1vrdA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 VAL A 429
ILE A  26
SER A 434
ALA A 441
 None
 0.89A 4eyzA-1vrdA:
undetectable		 4eyzA-1vrdA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 VAL A 429
ILE A  26
SER A 434
ALA A 441
 None
 0.90A 4eyzB-1vrdA:
undetectable		 4eyzB-1vrdA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 ASN A 273
GLY A 294
PHE A   7
ILE A 337
 None
 0.88A 4fglC-1vrdA:
undetectable		 4fglC-1vrdA:
18.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 ASN A 273
GLY A 296
CYH A 301
THR A 303
 None
 0.76A 4fo4B-1vrdA:
46.1		 4fo4B-1vrdA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 ASN A 273
GLY A 296
CYH A 301
THR A 303
ASP A 334
 None
 0.84A 4fxsA-1vrdA:
49.4		 4fxsA-1vrdA:
55.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 LEU A 314
PHE A   7
GLY A 350
ALA A 351
VAL A 293
 None
 1.03A 4nkxA-1vrdA:
undetectable		 4nkxA-1vrdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		6 / 12 LEU A 314
PHE A   7
GLY A 350
ALA A 351
ILE A 337
VAL A 293
 None
 1.28A 4nkxB-1vrdA:
undetectable		 4nkxB-1vrdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 LEU A 314
PHE A   7
GLY A 350
ALA A 351
VAL A 293
 None
 1.03A 4nkxC-1vrdA:
undetectable		 4nkxC-1vrdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 LEU A 314
PHE A   7
GLY A 350
ALA A 351
VAL A 293
 None
 1.01A 4nkxD-1vrdA:
undetectable		 4nkxD-1vrdA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 LEU A  40
GLY A  61
ASN A 205
VAL A 425
VAL A 429
 None
 1.16A 4qd3A-1vrdA:
undetectable		 4qd3A-1vrdA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 ALA A 346
ALA A 349
VAL A 356
GLY A 335
ALA A 333
 None
 1.22A 4qvnY-1vrdA:
undetectable
4qvnZ-1vrdA:
undetectable		 4qvnY-1vrdA:
22.25
4qvnZ-1vrdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 11 ALA A 275
THR A 276
ALA A 316
GLY A 248
GLY A 272
 None
 1.10A 4qvwK-1vrdA:
undetectable
4qvwL-1vrdA:
undetectable		 4qvwK-1vrdA:
22.02
4qvwL-1vrdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 11 ALA A 275
THR A 276
ALA A 316
GLY A 248
GLY A 272
 None
 1.09A 4qvwY-1vrdA:
undetectable
4qvwZ-1vrdA:
undetectable		 4qvwY-1vrdA:
22.02
4qvwZ-1vrdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 LEU A 257
ILE A 260
LYS A 261
VAL A 230
 None
 1.22A 4tvtA-1vrdA:
undetectable		 4tvtA-1vrdA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 GLY A 294
ALA A 275
GLY A 296
PRO A 297
 None
 0.89A 4u9uA-1vrdA:
undetectable		 4u9uA-1vrdA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 GLY A 294
ALA A 275
GLY A 296
PRO A 297
 None
 0.91A 4u9uB-1vrdA:
undetectable		 4u9uB-1vrdA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 ILE A  63
LEU A  57
GLY A  61
GLY A  62
 None
 0.85A 5a06B-1vrdA:
2.7		 5a06B-1vrdA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 ALA A  54
GLY A  64
GLY A  62
LEU A  40
ALA A 219
 None
 0.98A 5c0oG-1vrdA:
undetectable		 5c0oG-1vrdA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 SER A  80
VAL A  79
GLY A 237
ALA A 236
 None
 0.96A 5k50A-1vrdA:
2.3		 5k50A-1vrdA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		6 / 12 GLY A 272
GLY A 248
THR A 245
VAL A 242
VAL A 293
ALA A 288
 None
 1.45A 5kpcA-1vrdA:
undetectable		 5kpcA-1vrdA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 ILE A 337
VAL A 354
PRO A  39
 None
 0.54A 5uunA-1vrdA:
undetectable		 5uunA-1vrdA:
20.40