SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vrg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.84A 1fb7A-1vrgA:
undetectable		 1fb7A-1vrgA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		4 / 7 MET A 410
SER A 338
ALA A 342
ILE A 308
 None
 1.06A 1fxhA-1vrgA:
undetectable
1fxhB-1vrgA:
undetectable		 1fxhA-1vrgA:
19.55
1fxhB-1vrgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		4 / 6 THR A 319
PHE A 312
PHE A 345
GLY A 311
 None
 1.15A 1kqbC-1vrgA:
undetectable
1kqbD-1vrgA:
undetectable		 1kqbC-1vrgA:
19.69
1kqbD-1vrgA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		4 / 6 PHE A 345
GLY A 311
THR A 319
PHE A 312
 None
 1.16A 1kqbC-1vrgA:
undetectable
1kqbD-1vrgA:
undetectable		 1kqbC-1vrgA:
19.69
1kqbD-1vrgA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 11 GLY A  79
VAL A  76
ILE A 110
GLY A 126
ILE A 125
ILE A  77
 None
 1.27A 1n49C-1vrgA:
undetectable		 1n49C-1vrgA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 10 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.78A 2aquA-1vrgA:
undetectable		 2aquA-1vrgA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 11 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.79A 2aquB-1vrgA:
undetectable		 2aquB-1vrgA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.78A 2avvB-1vrgA:
undetectable		 2avvB-1vrgA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		3 / 3 ASP A 418
ILE A 346
VAL A 360
 None
 0.48A 2avvD-1vrgA:
undetectable		 2avvD-1vrgA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.84A 2avvE-1vrgA:
undetectable		 2avvE-1vrgA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.85A 2fxeA-1vrgA:
undetectable		 2fxeA-1vrgA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 11 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
VAL A 360
 None
 1.32A 2nnpA-1vrgA:
undetectable		 2nnpA-1vrgA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
VAL A 360
 None
 1.22A 2o4kB-1vrgA:
undetectable		 2o4kB-1vrgA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
 None
 0.94A 2o4sB-1vrgA:
undetectable		 2o4sB-1vrgA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
VAL A 360
 None
 1.13A 2q5kB-1vrgA:
undetectable		 2q5kB-1vrgA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
VAL A 360
 None
 1.32A 2q63A-1vrgA:
undetectable		 2q63A-1vrgA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 12 THR A 319
LEU A 495
LEU A 357
ILE A 310
LEU A 349
PRO A 393
 None
 1.44A 2qxsA-1vrgA:
undetectable		 2qxsA-1vrgA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 12 THR A 319
LEU A 495
LEU A 357
ILE A 310
LEU A 349
PRO A 393
 None
 1.46A 2qxsB-1vrgA:
undetectable		 2qxsB-1vrgA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
VAL A 360
 None
 1.14A 2r5pD-1vrgA:
undetectable		 2r5pD-1vrgA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 11 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
VAL A 360
 None
 1.23A 2r5qB-1vrgA:
undetectable		 2r5qB-1vrgA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		4 / 7 PRO A 367
ILE A 376
PRO A 363
GLY A 364
 None
 0.91A 2y7kA-1vrgA:
undetectable		 2y7kA-1vrgA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.82A 2z54B-1vrgA:
undetectable		 2z54B-1vrgA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.88A 3bvbB-1vrgA:
undetectable		 3bvbB-1vrgA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
VAL A 360
 None
 1.33A 3d1xA-1vrgA:
undetectable		 3d1xA-1vrgA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 10 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.86A 3ekyA-1vrgA:
undetectable		 3ekyA-1vrgA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.88A 3el1B-1vrgA:
undetectable		 3el1B-1vrgA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 10 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
 None
 1.04A 3el9B-1vrgA:
undetectable		 3el9B-1vrgA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 144
GLY A 146
ILE A 110
LEU A 142
GLN A  93
 None
 1.26A 3fzgA-1vrgA:
undetectable		 3fzgA-1vrgA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.86A 3jw2A-1vrgA:
undetectable		 3jw2A-1vrgA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
VAL A 360
 None
 1.28A 3jw2B-1vrgA:
undetectable		 3jw2B-1vrgA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.85A 3k4vA-1vrgA:
undetectable		 3k4vA-1vrgA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.86A 3tl9A-1vrgA:
undetectable		 3tl9A-1vrgA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LEU A 330
GLY A 364
ILE A 308
GLY A 380
ILE A 376
 None
 0.96A 3ucbA-1vrgA:
undetectable		 3ucbA-1vrgA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		4 / 4 LEU A 334
ILE A 398
TYR A 403
TYR A 387
 None
 1.22A 3vt7A-1vrgA:
0.0		 3vt7A-1vrgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		3 / 3 ASP A  74
GLU A 104
GLY A 103
 None
 0.71A 3w9tA-1vrgA:
undetectable		 3w9tA-1vrgA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LYS A  34
ASP A  94
GLY A  99
LEU A 102
ASP A 129
 None
 1.11A 4blvB-1vrgA:
undetectable		 4blvB-1vrgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 10 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.88A 4dqfB-1vrgA:
undetectable		 4dqfB-1vrgA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 VAL A 284
ILE A 356
GLY A 311
GLY A 321
ILE A 288
 None
 1.00A 4iv0A-1vrgA:
undetectable		 4iv0A-1vrgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.80A 4jecA-1vrgA:
undetectable		 4jecA-1vrgA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		4 / 8 VAL A 284
TYR A 282
VAL A 309
ILE A 308
 None
 0.89A 4jq1B-1vrgA:
undetectable		 4jq1B-1vrgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		3 / 3 ARG A 151
LEU A 150
GLU A 147
 None
 0.48A 4l3gF-1vrgA:
undetectable		 4l3gF-1vrgA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 11 VAL A 174
ALA A 173
TYR A 175
GLY A 196
GLY A 132
 None
None
None
BCT  A 517 (-3.7A)
None
 1.20A 4mm9A-1vrgA:
0.0		 4mm9A-1vrgA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 VAL A 284
ILE A 356
GLY A 311
GLY A 321
ILE A 288
 None
 0.99A 4mwzB-1vrgA:
undetectable		 4mwzB-1vrgA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LEU A 349
GLY A 321
VAL A 309
ILE A 491
VAL A 291
 None
 1.32A 4okwA-1vrgA:
undetectable		 4okwA-1vrgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 10 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.81A 4q1yA-1vrgA:
undetectable		 4q1yA-1vrgA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 11 GLY A 416
ALA A 417
ASP A 418
ILE A 346
VAL A 360
 None
 0.92A 4qgiA-1vrgA:
undetectable		 4qgiA-1vrgA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		4 / 6 TYR A 470
ILE A 398
VAL A 481
ALA A 422
 None
 0.89A 5cu6A-1vrgA:
undetectable		 5cu6A-1vrgA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		3 / 3 TRP A  38
ILE A  77
SER A  92
 None
 0.90A 5gqbA-1vrgA:
3.1		 5gqbA-1vrgA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 9 SER A  92
GLY A 126
ALA A 236
VAL A 164
ILE A 162
 None
 1.32A 5i3cA-1vrgA:
3.5		 5i3cA-1vrgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		3 / 3 GLY A 132
GLY A 131
GLN A  93
 None
 0.48A 5imsA-1vrgA:
2.2		 5imsA-1vrgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		3 / 3 MET A 237
GLU A  39
ARG A  40
 None
 1.13A 5tjyA-1vrgA:
undetectable		 5tjyA-1vrgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		3 / 3 PHE A 345
ASP A 181
LEU A 515
 None
 0.72A 5uhbC-1vrgA:
undetectable		 5uhbC-1vrgA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		3 / 3 PHE A 345
ASP A 181
LEU A 515
 None
 0.78A 5uhcC-1vrgA:
undetectable		 5uhcC-1vrgA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
VAL A 360
 None
 1.11A 6dj1B-1vrgA:
undetectable		 6dj1B-1vrgA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		6 / 12 GLY A 416
ALA A 417
ASP A 418
ILE A 395
ILE A 346
VAL A 360
 None
 1.10A 6dj2B-1vrgA:
undetectable		 6dj2B-1vrgA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		4 / 7 GLY A  75
SER A 130
GLY A 100
VAL A  97
 None
 0.91A 6ekzA-1vrgA:
undetectable		 6ekzA-1vrgA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ILE A 310
ILE A 356
PHE A 182
HIS A 227
PHE A 348
 None
 1.34A 6j21A-1vrgA:
undetectable		 6j21A-1vrgA:
20.99