SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		4 / 7 LEU A 335
VAL A 289
GLY A 288
ASP A 316
 None
 0.84A 1t88A-1vrmA:
undetectable		 1t88A-1vrmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		5 / 12 ALA A 205
ILE A 204
ILE A 225
VAL A 216
LEU A  53
 None
MPD  A   1 ( 4.2A)
None
None
None
 0.98A 1uduB-1vrmA:
undetectable		 1uduB-1vrmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		5 / 12 ALA A 205
ILE A 204
ILE A 225
VAL A 216
LEU A  53
 None
MPD  A   1 ( 4.2A)
None
None
None
 0.97A 1xozA-1vrmA:
undetectable		 1xozA-1vrmA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		4 / 8 LEU A 335
VAL A 289
GLY A 288
ASP A 316
 None
 0.80A 2a1oA-1vrmA:
undetectable		 2a1oA-1vrmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		5 / 12 PHE A 346
ILE A 277
ALA A 304
THR A 301
ALA A 329
 None
UNL  A   4 ( 4.0A)
None
None
None
 1.10A 2j0dA-1vrmA:
undetectable		 2j0dA-1vrmA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		5 / 12 ARG A  81
VAL A  94
PHE A  86
GLU A 111
ASP A  78
 None
None
None
None
MPD  A   1 ( 4.9A)
 1.44A 2qeoA-1vrmA:
undetectable		 2qeoA-1vrmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		3 / 3 ARG A 136
GLY A 135
SER A  93
 MRD  A   2 ( 3.3A)
None
None
 0.57A 2xctB-1vrmA:
undetectable		 2xctB-1vrmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		6 / 12 LEU A 198
ALA A 256
ILE A 294
ILE A 225
ALA A 201
ASP A 221
 None
None
None
None
None
UNL  A   4 (-2.5A)
 1.43A 3axtA-1vrmA:
undetectable		 3axtA-1vrmA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		5 / 8 ASP A 199
GLY A 195
ALA A 299
ASP A 221
LEU A 305
 None
None
None
UNL  A   4 (-2.5A)
None
 1.45A 3em6A-1vrmA:
undetectable		 3em6A-1vrmA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		3 / 3 ARG A  58
ILE A 224
TRP A 234
 MPD  A   3 (-3.9A)
None
None
 1.07A 3nw2A-1vrmA:
undetectable		 3nw2A-1vrmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		3 / 3 ARG A  58
ILE A 224
TRP A 234
 MPD  A   3 (-3.9A)
None
None
 1.16A 3nw2B-1vrmA:
undetectable		 3nw2B-1vrmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		5 / 12 PHE A 346
ILE A 277
ALA A 304
THR A 301
ALA A 329
 None
UNL  A   4 ( 4.0A)
None
None
None
 1.26A 3ua1A-1vrmA:
0.0		 3ua1A-1vrmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		4 / 7 ILE A 158
LEU A 137
LYS A 168
GLY A 166
 None
 1.04A 4hajA-1vrmA:
undetectable		 4hajA-1vrmA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		5 / 7 TYR A 196
ILE A  82
ASP A 188
LEU A 189
GLY A 190
 None
None
UNL  A   4 (-3.2A)
None
UNL  A   4 (-3.8A)
 1.36A 4iqqA-1vrmA:
undetectable		 4iqqA-1vrmA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		8 / 12 PHE A 130
ASP A 188
GLY A 190
HIS A 276
ILE A 277
PRO A 280
THR A 307
VAL A 311
 UNL  A   4 ( 4.4A)
UNL  A   4 (-3.2A)
UNL  A   4 (-3.8A)
UNL  A   4 (-3.3A)
UNL  A   4 ( 4.0A)
UNL  A   4 (-4.1A)
UNL  A   4 (-2.7A)
None
 0.69A 4xdrA-1vrmA:
37.4		 4xdrA-1vrmA:
31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		5 / 9 THR A 293
VAL A 238
GLY A 237
VAL A 222
VAL A 257
 None
 1.22A 5cp4A-1vrmA:
undetectable		 5cp4A-1vrmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		5 / 12 ASP A  50
ALA A  52
GLY A 220
THR A 259
GLU A 217
 None
 1.25A 5hfjE-1vrmA:
undetectable		 5hfjE-1vrmA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		5 / 12 ASP A 316
PHE A 310
ILE A 277
ALA A 258
ALA A 329
 None
None
UNL  A   4 ( 4.0A)
UNL  A   4 ( 3.8A)
None
 1.26A 5vcgA-1vrmA:
undetectable		 5vcgA-1vrmA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		4 / 8 ASP A 303
THR A 300
TYR A 196
LEU A  53
 UNL  A   4 (-3.7A)
None
None
None
 1.15A 5w97A-1vrmA:
1.0
5w97C-1vrmA:
undetectable
5w97c-1vrmA:
undetectable		 5w97A-1vrmA:
20.11
5w97C-1vrmA:
20.42
5w97c-1vrmA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		4 / 7 LEU A  53
ASP A 303
THR A 300
TYR A 196
 None
UNL  A   4 (-3.7A)
None
None
 1.13A 5w97C-1vrmA:
0.4
5w97a-1vrmA:
1.0
5w97c-1vrmA:
0.4		 5w97C-1vrmA:
20.42
5w97a-1vrmA:
20.11
5w97c-1vrmA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		4 / 8 ASP A 303
THR A 300
TYR A 196
LEU A  53
 UNL  A   4 (-3.7A)
None
None
None
 1.16A 5x19A-1vrmA:
undetectable
5x19C-1vrmA:
undetectable
5x19P-1vrmA:
undetectable		 5x19A-1vrmA:
20.11
5x19C-1vrmA:
20.42
5x19P-1vrmA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		4 / 7 ASP A 303
THR A 300
TYR A 196
LEU A  53
 UNL  A   4 (-3.7A)
None
None
None
 1.13A 5x1bA-1vrmA:
undetectable
5x1bC-1vrmA:
undetectable
5x1bP-1vrmA:
undetectable		 5x1bA-1vrmA:
20.11
5x1bC-1vrmA:
20.42
5x1bP-1vrmA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		4 / 7 ASP A 303
THR A 300
TYR A 196
LEU A  53
 UNL  A   4 (-3.7A)
None
None
None
 1.17A 5x1fA-1vrmA:
undetectable
5x1fC-1vrmA:
undetectable
5x1fP-1vrmA:
undetectable		 5x1fA-1vrmA:
20.11
5x1fC-1vrmA:
20.42
5x1fP-1vrmA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		4 / 7 LEU A  53
ASP A 303
THR A 300
TYR A 196
 None
UNL  A   4 (-3.7A)
None
None
 1.24A 5z84C-1vrmA:
0.2
5z84N-1vrmA:
1.1
5z84P-1vrmA:
0.3		 5z84C-1vrmA:
20.42
5z84N-1vrmA:
20.11
5z84P-1vrmA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		5 / 10 ILE A 340
VAL A 320
LEU A 335
LEU A 332
LEU A 331
 None
 1.02A 6f6nA-1vrmA:
0.0
6f6nB-1vrmA:
0.0		 6f6nA-1vrmA:
13.67
6f6nB-1vrmA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		4 / 8 LEU A  53
ASP A 303
THR A 300
TYR A 196
 None
UNL  A   4 (-3.7A)
None
None
 1.11A 6nknC-1vrmA:
undetectable
6nknN-1vrmA:
undetectable
6nknP-1vrmA:
undetectable		 6nknC-1vrmA:
20.42
6nknN-1vrmA:
20.11
6nknP-1vrmA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1vrm HYPOTHETICAL PROTEIN
TM1553
(Thermotoga
maritima) 		4 / 7 ASP A 303
THR A 300
TYR A 196
LEU A  53
 UNL  A   4 (-3.7A)
None
None
None
 1.15A 6nmfA-1vrmA:
undetectable
6nmfC-1vrmA:
undetectable
6nmfP-1vrmA:
undetectable		 6nmfA-1vrmA:
20.11
6nmfC-1vrmA:
20.42
6nmfP-1vrmA:
20.42