SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vrp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		4 / 8 ALA A  76
LEU A  88
HIS A  97
LEU A 287
 None
 0.90A 1ereE-1vrpA:
undetectable		 1ereE-1vrpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		4 / 6 PRO A 144
MET A 207
GLU A 231
GLU A 232
 None
None
MG  A 404 ( 4.5A)
MG  A 404 (-4.1A)
 1.45A 1qhyA-1vrpA:
undetectable		 1qhyA-1vrpA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		3 / 3 ARG A 130
VAL A 227
TRP A 228
 ADP  A 400 (-3.1A)
None
None
 1.18A 1qw6A-1vrpA:
undetectable		 1qw6A-1vrpA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		3 / 3 LYS A  86
ILE A  56
THR A  35
 None
 0.79A 1rx3A-1vrpA:
undetectable		 1rx3A-1vrpA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		3 / 3 ARG A 130
VAL A 227
TRP A 228
 ADP  A 400 (-3.1A)
None
None
 1.18A 1zviA-1vrpA:
undetectable		 1zviA-1vrpA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		4 / 7 HIS A 106
ASN A 274
GLY A 288
TYR A 279
 None
 1.01A 2f6dA-1vrpA:
undetectable		 2f6dA-1vrpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		5 / 12 LEU A  42
LEU A  53
LEU A  23
PRO A  21
VAL A  61
 None
 1.40A 2qd4A-1vrpA:
undetectable		 2qd4A-1vrpA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		3 / 3 ARG A 209
GLU A 155
SER A 205
 None
 0.72A 2xkkA-1vrpA:
undetectable
2xkkC-1vrpA:
undetectable		 2xkkA-1vrpA:
20.13
2xkkC-1vrpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		5 / 11 ILE A 333
HIS A 296
VAL A 361
ASP A 122
PRO A 123
 None
ADP  A 400 (-3.6A)
None
None
None
 1.47A 2zweA-1vrpA:
undetectable
2zweB-1vrpA:
0.2		 2zweA-1vrpA:
21.34
2zweB-1vrpA:
14.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		4 / 6 THR A  71
VAL A  72
CYH A 283
SER A 285
 None
 0.41A 3b6rB-1vrpA:
54.3		 3b6rB-1vrpA:
78.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		4 / 5 ILE A  93
HIS A  97
TYR A  82
GLY A 288
 None
 1.28A 3b9mA-1vrpA:
undetectable		 3b9mA-1vrpA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		3 / 3 PHE A  51
CYH A  81
PHE A  89
 None
 1.08A 3cr5X-1vrpA:
undetectable		 3cr5X-1vrpA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		5 / 9 ILE A 299
TYR A 334
ILE A 336
LYS A 319
LEU A 312
 None
 1.43A 3f78A-1vrpA:
undetectable		 3f78A-1vrpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		5 / 9 ILE A 299
TYR A 334
ILE A 336
LYS A 319
LEU A 312
 None
 1.42A 3f78B-1vrpA:
undetectable		 3f78B-1vrpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		4 / 7 ASN A  28
MET A  30
LEU A  88
LEU A  23
 None
 1.21A 3nk2X-1vrpA:
undetectable		 3nk2X-1vrpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		3 / 3 GLY A 331
GLY A 323
THR A 327
 None
 0.46A 3si7B-1vrpA:
undetectable		 3si7B-1vrpA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		5 / 9 PHE A 225
VAL A 227
PHE A 271
GLY A 134
PHE A 264
 None
 1.34A 3t3rB-1vrpA:
undetectable		 3t3rB-1vrpA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		5 / 9 PHE A 225
VAL A 227
PHE A 271
GLY A 134
PHE A 264
 None
 1.34A 3t3rC-1vrpA:
0.0		 3t3rC-1vrpA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		5 / 10 PHE A 225
VAL A 227
PHE A 271
GLY A 134
PHE A 264
 None
 1.36A 3t3rD-1vrpA:
0.0		 3t3rD-1vrpA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		3 / 3 LYS A  86
ILE A  56
THR A  35
 None
 0.82A 4gh8A-1vrpA:
undetectable		 4gh8A-1vrpA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		4 / 6 THR A 282
PRO A 284
PHE A  51
PHE A  89
 None
 1.49A 4kf9A-1vrpA:
undetectable		 4kf9A-1vrpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		5 / 12 THR A 282
ALA A  76
LEU A  88
HIS A  97
LEU A 287
 None
 1.14A 4xi3D-1vrpA:
undetectable		 4xi3D-1vrpA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		4 / 5 ILE A  38
LEU A  23
HIS A  29
VAL A  92
 None
 1.20A 5jmnB-1vrpA:
2.4		 5jmnB-1vrpA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		5 / 11 ILE A 333
HIS A 296
VAL A 361
ASP A 122
PRO A 123
 None
ADP  A 400 (-3.6A)
None
None
None
 1.43A 5z0iA-1vrpA:
undetectable
5z0iB-1vrpA:
undetectable		 5z0iA-1vrpA:
13.17
5z0iB-1vrpA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		5 / 12 ASP A 120
ILE A 336
GLU A 362
VAL A 361
ILE A 299
 None
 1.00A 6ectA-1vrpA:
undetectable		 6ectA-1vrpA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		5 / 12 ASP A 120
ILE A 336
GLU A 362
VAL A 361
ILE A 299
 None
 1.03A 6ecxA-1vrpA:
undetectable		 6ecxA-1vrpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vrp CREATINE KINASE, M
CHAIN
(Tetronarce
californica) 		4 / 6 LYS A 172
GLN A 170
LEU A 226
PHE A 192
 None
 1.13A 6nmpC-1vrpA:
0.0
6nmpJ-1vrpA:
undetectable		 6nmpC-1vrpA:
22.11
6nmpJ-1vrpA:
10.55