SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vs0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 559
LEU A 581
GLU A 582
LEU A 595
 APK  A 481 ( 3.4A)
None
None
None
 1.06A 1cmaA-1vs0A:
undetectable
1cmaB-1vs0A:
undetectable		 1cmaA-1vs0A:
15.86
1cmaB-1vs0A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 479
GLU A 582
LEU A 581
ALA A 558
PHE A 559
 APK  A 481 ( 4.2A)
None
None
None
APK  A 481 ( 3.4A)
 1.37A 1cmaA-1vs0A:
undetectable
1cmaB-1vs0A:
undetectable		 1cmaA-1vs0A:
15.86
1cmaB-1vs0A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 558
PHE A 559
GLU A 479
GLU A 582
LEU A 581
 None
APK  A 481 ( 3.4A)
APK  A 481 ( 4.2A)
None
None
 1.42A 1cmcA-1vs0A:
undetectable
1cmcB-1vs0A:
undetectable		 1cmcA-1vs0A:
15.86
1cmcB-1vs0A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 523
VAL A 525
LEU A 527
LEU A 590
THR A 588
 None
 1.24A 1dmyA-1vs0A:
undetectable		 1dmyA-1vs0A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		3 / 4 VAL A 679
TRP A 649
TRP A 744
 None
 1.26A 1gmkC-1vs0A:
undetectable
1gmkD-1vs0A:
undetectable		 1gmkC-1vs0A:
7.10
1gmkD-1vs0A:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 486
ASP A 560
ASP A 528
TYR A 624
 APK  A 481 ( 4.0A)
None
None
None
 1.07A 2e5dA-1vs0A:
undetectable
2e5dB-1vs0A:
undetectable		 2e5dA-1vs0A:
19.80
2e5dB-1vs0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 528
TYR A 624
ARG A 486
ASP A 560
 None
None
APK  A 481 ( 4.0A)
None
 1.09A 2e5dA-1vs0A:
undetectable
2e5dB-1vs0A:
undetectable		 2e5dA-1vs0A:
19.80
2e5dB-1vs0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		5 / 8 HIS A 523
ALA A 491
VAL A 525
LEU A 590
THR A 588
 None
 1.39A 2it4A-1vs0A:
undetectable		 2it4A-1vs0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 570
TYR A 624
GLN A 625
 None
 0.63A 2wekA-1vs0A:
undetectable		 2wekA-1vs0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		4 / 8 SER A 607
PHE A 604
VAL A 634
LEU A 471
 None
 0.97A 3jq7C-1vs0A:
undetectable		 3jq7C-1vs0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 752
PRO A 753
SER A 754
 None
 0.39A 4k50I-1vs0A:
undetectable		 4k50I-1vs0A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 486
ASP A 560
SER A 622
TYR A 624
 APK  A 481 ( 4.0A)
None
None
None
 0.99A 4lv9A-1vs0A:
undetectable
4lv9B-1vs0A:
undetectable		 4lv9A-1vs0A:
19.49
4lv9B-1vs0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 620
ASP A 621
ARG A 619
 None
 0.53A 4wq4B-1vs0A:
undetectable		 4wq4B-1vs0A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 574
LYS A 618
GLY A 480
LEU A 595
 None
APK  A 481 ( 2.9A)
APK  A 481 ( 2.5A)
None
 0.86A 5bphB-1vs0A:
undetectable		 5bphB-1vs0A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 592
PHE A 559
CYH A 606
LEU A 595
ALA A 473
 None
APK  A 481 ( 3.4A)
None
None
None
 1.50A 5fctB-1vs0A:
0.0		 5fctB-1vs0A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 581
LEU A 590
ALA A 558
LEU A 458
LEU A 570
 None
 1.12A 5ljeA-1vs0A:
undetectable		 5ljeA-1vs0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		3 / 3 ILE A 667
VAL A 756
PRO A 753
 None
 0.72A 5uunA-1vs0A:
undetectable		 5uunA-1vs0A:
22.50