SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vs1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		4 / 8 THR A 259
PRO A 260
GLY A 261
ARG A 265
 None
 0.82A 1h4oG-1vs1A:
undetectable		 1h4oG-1vs1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		3 / 3 THR A 259
LEU A 258
LEU A 239
 None
 0.59A 1mz9C-1vs1A:
undetectable		 1mz9C-1vs1A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		4 / 8 THR A 259
PRO A 260
GLY A 261
ARG A 265
 None
 0.82A 1oc3A-1vs1A:
2.1		 1oc3A-1vs1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		4 / 7 ARG A 130
ARG A 181
GLN A 126
GLU A 108
 PEP  A 302 (-3.4A)
PEP  A 302 (-3.8A)
PEP  A 302 (-3.7A)
PEP  A 302 ( 4.3A)
 1.32A 2c8aA-1vs1A:
undetectable		 2c8aA-1vs1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		5 / 9 ALA A 228
ALA A 236
GLY A 235
GLY A 238
ILE A 211
 None
 1.28A 2v7bA-1vs1A:
undetectable		 2v7bA-1vs1A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		5 / 9 ALA A 228
ALA A 236
GLY A 235
GLY A 238
ILE A 211
 None
 1.29A 2v7bB-1vs1A:
undetectable		 2v7bB-1vs1A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		3 / 3 SER A 215
ARG A 191
GLN A 256
 None
None
MN  A 301 ( 4.9A)
 0.69A 2xnrA-1vs1A:
undetectable		 2xnrA-1vs1A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		5 / 10 ASN A 173
VAL A 141
TYR A 167
GLY A 142
LEU A 150
 None
 1.43A 3lp1A-1vs1A:
undetectable		 3lp1A-1vs1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		5 / 12 ASN A 173
VAL A 141
TYR A 167
GLY A 142
LEU A 150
 None
 1.36A 3medA-1vs1A:
undetectable
3medB-1vs1A:
undetectable		 3medA-1vs1A:
18.94
3medB-1vs1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		4 / 6 GLU A 171
ILE A 168
GLU A 108
VAL A 118
 None
None
PEP  A 302 ( 4.3A)
None
 1.05A 4ejwB-1vs1A:
undetectable		 4ejwB-1vs1A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		5 / 12 GLY A  65
ALA A  66
VAL A  41
LEU A 276
PHE A 263
 None
 1.13A 4pd5A-1vs1A:
undetectable		 4pd5A-1vs1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		3 / 3 SER A  38
ALA A  40
VAL A  41
 None
 0.66A 4x20C-1vs1A:
undetectable		 4x20C-1vs1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		4 / 5 LEU A 266
ALA A  43
VAL A 212
ILE A 211
 None
 0.88A 4xe3B-1vs1A:
undetectable		 4xe3B-1vs1A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		5 / 12 GLU A 171
GLY A 142
ARG A 143
GLU A 108
LEU A 137
 None
None
None
PEP  A 302 ( 4.3A)
None
 1.48A 5fhzD-1vs1A:
undetectable		 5fhzD-1vs1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		5 / 12 LEU A  69
GLY A 238
ASP A 237
LEU A 103
ALA A  66
 None
 1.12A 5h5fA-1vs1A:
undetectable		 5h5fA-1vs1A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		5 / 12 ALA A 236
ASN A 156
GLU A 160
LEU A 162
GLU A 159
 None
 1.25A 5nwuA-1vs1A:
undetectable		 5nwuA-1vs1A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		5 / 12 GLY A 238
GLY A 231
GLU A 180
ALA A 218
GLN A 256
 None
None
None
None
MN  A 301 ( 4.9A)
 0.94A 5x7fA-1vs1A:
undetectable		 5x7fA-1vs1A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		5 / 12 GLY A  72
GLY A  71
VAL A 106
GLN A 257
GLY A  44
 None
 1.15A 6gneA-1vs1A:
undetectable		 6gneA-1vs1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE
(Aeropyrum
pernix) 		5 / 12 GLY A  72
GLY A  71
VAL A 106
GLN A 257
GLY A  44
 None
 1.14A 6gneB-1vs1A:
undetectable		 6gneB-1vs1A:
22.11