SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vs3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1vs3 TRNA PSEUDOURIDINE
SYNTHASE A
(Thermus
thermophilus) 		5 / 11 GLY A 209
GLY A 211
SER A 217
ALA A 139
ALA A 143
 None
 0.94A 1x7pA-1vs3A:
undetectable
1x7pB-1vs3A:
undetectable		 1x7pA-1vs3A:
26.95
1x7pB-1vs3A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1vs3 TRNA PSEUDOURIDINE
SYNTHASE A
(Thermus
thermophilus) 		4 / 6 ARG A  81
GLU A  73
PRO A  71
ALA A  69
 None
 1.47A 2ejfB-1vs3A:
1.9		 2ejfB-1vs3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1vs3 TRNA PSEUDOURIDINE
SYNTHASE A
(Thermus
thermophilus) 		4 / 8 ILE A  39
ALA A  41
LEU A   4
ALA A  45
 None
 0.96A 3hrdA-1vs3A:
undetectable
3hrdB-1vs3A:
undetectable		 3hrdA-1vs3A:
20.42
3hrdB-1vs3A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 1vs3 TRNA PSEUDOURIDINE
SYNTHASE A
(Thermus
thermophilus) 		4 / 4 PRO A 232
THR A 233
GLY A  54
THR A  13
 None
 1.01A 3ib1A-1vs3A:
undetectable		 3ib1A-1vs3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1vs3 TRNA PSEUDOURIDINE
SYNTHASE A
(Thermus
thermophilus) 		5 / 12 ALA A 139
ASP A 136
LEU A 137
ILE A 114
LEU A 173
 None
 1.22A 3nrrB-1vs3A:
undetectable		 3nrrB-1vs3A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 1vs3 TRNA PSEUDOURIDINE
SYNTHASE A
(Thermus
thermophilus) 		6 / 12 LEU A 218
GLY A 231
ALA A 230
ASP A 226
VAL A 198
ILE A 221
 None
 1.42A 3nu5A-1vs3A:
undetectable		 3nu5A-1vs3A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1vs3 TRNA PSEUDOURIDINE
SYNTHASE A
(Thermus
thermophilus) 		4 / 8 LEU A 144
MET A 140
THR A 204
TYR A 112
 None
 1.21A 3wipF-1vs3A:
undetectable
3wipJ-1vs3A:
undetectable		 3wipF-1vs3A:
20.75
3wipJ-1vs3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1vs3 TRNA PSEUDOURIDINE
SYNTHASE A
(Thermus
thermophilus) 		5 / 9 LEU A  36
ILE A  39
GLY A  38
LEU A  32
LEU A  83
 None
 0.94A 5o96A-1vs3A:
undetectable
5o96B-1vs3A:
undetectable		 5o96A-1vs3A:
22.66
5o96B-1vs3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1vs3 TRNA PSEUDOURIDINE
SYNTHASE A
(Thermus
thermophilus) 		4 / 6 VAL A 116
LEU A 135
LEU A 137
LEU A 186
 None
 1.07A 6f6sA-1vs3A:
undetectable
6f6sB-1vs3A:
0.0		 6f6sA-1vs3A:
14.61
6f6sB-1vs3A:
13.69