SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vsg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2
(Trypanosoma
brucei) 		4 / 8 SER A  88
LEU A  80
ALA A  36
ALA A  35
 None
 0.98A 3ns1L-1vsgA:
undetectable		 3ns1L-1vsgA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2
(Trypanosoma
brucei) 		5 / 10 LEU A 315
ALA A  64
ILE A 268
GLY A 303
ILE A 312
 None
 0.96A 3oxwB-1vsgA:
undetectable		 3oxwB-1vsgA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2
(Trypanosoma
brucei) 		3 / 3 SER A 236
GLY A 237
GLN A 241
 None
 0.58A 3v4tH-1vsgA:
undetectable		 3v4tH-1vsgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2
(Trypanosoma
brucei) 		3 / 3 HIS A  71
GLU A 313
ASN A 306
 None
NAG  A 366 (-3.5A)
None
 0.96A 4bupB-1vsgA:
undetectable		 4bupB-1vsgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2
(Trypanosoma
brucei) 		5 / 11 LEU A 315
ALA A  64
ILE A 268
GLY A 303
ILE A 312
 None
 0.96A 4njtC-1vsgA:
undetectable		 4njtC-1vsgA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2
(Trypanosoma
brucei) 		5 / 10 THR A 258
ALA A  82
THR A  86
GLY A 255
ALA A  35
 None
 1.35A 5l66K-1vsgA:
undetectable
5l66L-1vsgA:
undetectable		 5l66K-1vsgA:
20.60
5l66L-1vsgA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2
(Trypanosoma
brucei) 		5 / 10 THR A 258
ALA A  82
THR A  86
GLY A 255
ALA A  35
 None
 1.36A 5l66Y-1vsgA:
undetectable
5l66Z-1vsgA:
undetectable		 5l66Y-1vsgA:
20.60
5l66Z-1vsgA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2
(Trypanosoma
brucei) 		5 / 7 GLY A 197
GLU A   3
LYS A   4
ALA A   2
ASN A 194
 None
 1.45A 5mvsA-1vsgA:
undetectable		 5mvsA-1vsgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2
(Trypanosoma
brucei) 		3 / 3 HIS A  71
GLU A 313
ASN A 306
 None
NAG  A 366 (-3.5A)
None
 0.92A 5wbvA-1vsgA:
undetectable		 5wbvA-1vsgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2
(Trypanosoma
brucei) 		3 / 3 HIS A  71
GLU A 313
ASN A 306
 None
NAG  A 366 (-3.5A)
None
 0.92A 5wbvB-1vsgA:
undetectable		 5wbvB-1vsgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2
(Trypanosoma
brucei) 		4 / 7 LEU A  32
ALA A  34
ALA A  35
THR A 258
 None
 0.77A 6a7jA-1vsgA:
undetectable		 6a7jA-1vsgA:
12.08